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PMID:11057898
| Citation |
Schmelzle, T and Hall, MN (2000) TOR, a central controller of cell growth. Cell 103:253-62 |
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| Abstract |
Cell growth (increase in cell mass) and cell proliferation (increase in cell number) are distinct yet coupled processes that go hand-in-hand to give rise to an organ, organism, or tumor. Cyclin-dependent kinase(s) is the central regulator of cell proliferation. Is there an equivalent regulator for cell growth? Recent findings reveal that the target of rapamycin TOR controls an unusually abundant and diverse set of readouts all of which are important for cell growth, suggesting that this conserved kinase is such a central regulator. |
| Links | |
| Keywords |
Cell Cycle Proteins; Cell Division; Fungal Proteins/metabolism; Models, Biological; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor)/metabolism; Protein Kinases; Saccharomyces cerevisiae Proteins; Signal Transduction; TOR Serine-Threonine Kinases |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0001558: regulation of cell growth |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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