YEAST:SCC1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	MCD1 (synonyms: PDS3, RHC21, SCC1)
Protein Name(s)	Sister chromatid cohesion protein 1
External Links
UniProt	Q12158
EMBL	Y14280 U23759 Z48008 Z48432 Z74051 BK006938
PIR	S50979
RefSeq	NP_010281.1
PDB	1W1W
PDBsum	1W1W
ProteinModelPortal	Q12158
SMR	Q12158
BioGrid	32051
DIP	DIP-5812N
IntAct	Q12158
MINT	MINT-627334
MaxQB	Q12158
PaxDb	Q12158
PeptideAtlas	Q12158
EnsemblFungi	[example_ID YDL003W]
GeneID	851561
KEGG	sce:YDL003W
CYGD	YDL003w
SGD	S000002161
eggNOG	NOG249424
HOGENOM	HOG000141751
InParanoid	Q12158
KO	K06670
OMA	QIWLASN
OrthoDB	EOG7KSXM4
BioCyc	YEAST:G3O-29434-MONOMER
EvolutionaryTrace	Q12158
NextBio	968995
PMAP-CutDB	Q12158
Proteomes	UP000002311
Genevestigator	Q12158
GO	GO:0000775 GO:0000794 GO:0005739 GO:0034990 GO:0005634 GO:0003682 GO:0006915 GO:0006974 GO:0006268 GO:0006302 GO:0034087 GO:0007076 GO:0006473 GO:1990414
Gene3D	1.10.10.580
InterPro	IPR023093 IPR006909 IPR006910
Pfam	PF04824 PF04825

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:27325700^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000002520	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:27325700^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P32562	F	has_direct_input:(GO:0034990) happens_during:(GO:0000086)	Seeded From UniProt	complete
involved_in	GO:1990414	replication-born double-strand break repair via sister chromatid exchange	PMID:16888651^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034990	nuclear mitotic cohesin complex	PMID:9990856^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034087	establishment of mitotic sister chromatid cohesion	PMID:16962805^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007076	mitotic chromosome condensation	PMID:9335334^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:18614046^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:18321989^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:23178808^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:11448778^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18321989^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15282802^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:9990856^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18614046^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	PMID:18614046^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006473	protein acetylation	PMID:11864574^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007062	sister chromatid cohesion	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000286904 TAIR:locus:2169667 TAIR:locus:2181457	P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3652039 PANTHER:PTN000286904 PomBase:SPCC338.17c SGD:S000002161 TAIR:locus:2181457 UniProtKB:Q9FQ20	P		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000286904 SGD:S000002161 SGD:S000006211	F		Seeded From UniProt	complete
involved_in	GO:0007062	sister chromatid cohesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039781	P		Seeded From UniProt	complete
part_of	GO:0008278	cohesin complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039781	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137 UniProtKB-SubCell:SL-0047	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0159	P		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Pakchuen, S et al. (2016) Physical Association of Saccharomyces cerevisiae Polo-like Kinase Cdc5 with Chromosomal Cohesin Facilitates DNA Damage Response. J. Biol. Chem. 291 17228-46 PubMed GONUTS page
↑ Cortés-Ledesma, F & Aguilera, A (2006) Double-strand breaks arising by replication through a nick are repaired by cohesin-dependent sister-chromatid exchange. EMBO Rep. 7 919-26 PubMed GONUTS page
↑ ^3.0 ^3.1 Tóth, A et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev. 13 320-33 PubMed GONUTS page
↑ Lengronne, A et al. (2006) Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol. Cell 23 787-99 PubMed GONUTS page
↑ Guacci, V et al. (1997) A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell 91 47-57 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Heidinger-Pauli, JM et al. (2008) The kleisin subunit of cohesin dictates damage-induced cohesion. Mol. Cell 31 47-56 PubMed GONUTS page
↑ ^7.0 ^7.1 Yang, H et al. (2008) Cleavage of Mcd1 by caspase-like protease Esp1 promotes apoptosis in budding yeast. Mol. Biol. Cell 19 2127-34 PubMed GONUTS page
↑ McAleenan, A et al. (2013) Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin. Nature 493 250-4 PubMed GONUTS page
↑ Sjögren, C & Nasmyth, K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr. Biol. 11 991-5 PubMed GONUTS page
↑ Sundin, BA et al. (2004) Localization of proteins that are coordinately expressed with Cln2 during the cell cycle. Yeast 21 793-800 PubMed GONUTS page
↑ Ivanov, D et al. (2002) Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion. Curr. Biol. 12 323-8 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:27325700-1] 1.0 ^1.1 Pakchuen, S et al. (2016) Physical Association of Saccharomyces cerevisiae Polo-like Kinase Cdc5 with Chromosomal Cohesin Facilitates DNA Damage Response. J. Biol. Chem. 291 17228-46 PubMed GONUTS page

[PMID:16888651-2] Cortés-Ledesma, F & Aguilera, A (2006) Double-strand breaks arising by replication through a nick are repaired by cohesin-dependent sister-chromatid exchange. EMBO Rep. 7 919-26 PubMed GONUTS page

[PMID:9990856-3] 3.0 ^3.1 Tóth, A et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev. 13 320-33 PubMed GONUTS page

[PMID:16962805-4] Lengronne, A et al. (2006) Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol. Cell 23 787-99 PubMed GONUTS page

[PMID:9335334-5] Guacci, V et al. (1997) A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell 91 47-57 PubMed GONUTS page

[PMID:18614046-6] 6.0 ^6.1 ^6.2 Heidinger-Pauli, JM et al. (2008) The kleisin subunit of cohesin dictates damage-induced cohesion. Mol. Cell 31 47-56 PubMed GONUTS page

[PMID:18321989-7] 7.0 ^7.1 Yang, H et al. (2008) Cleavage of Mcd1 by caspase-like protease Esp1 promotes apoptosis in budding yeast. Mol. Biol. Cell 19 2127-34 PubMed GONUTS page

[PMID:23178808-8] McAleenan, A et al. (2013) Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin. Nature 493 250-4 PubMed GONUTS page

[PMID:11448778-9] Sjögren, C & Nasmyth, K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr. Biol. 11 991-5 PubMed GONUTS page

[PMID:15282802-10] Sundin, BA et al. (2004) Localization of proteins that are coordinately expressed with Cln2 during the cell cycle. Yeast 21 793-800 PubMed GONUTS page

[PMID:11864574-11] Ivanov, D et al. (2002) Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion. Curr. Biol. 12 323-8 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:SCC1

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