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YEAST:SAC3

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) SAC3 (synonyms: LEP1)
Protein Name(s) Nuclear mRNA export protein SAC3

Leucine permease transcriptional regulator

External Links
UniProt P46674
EMBL Z47805
Z50046
U35227
BK006938
PIR S51323
RefSeq NP_010443.3
PDB 3FWB
3FWC
3T5V
4C31
4MBE
PDBsum 3FWB
3FWC
3T5V
4C31
4MBE
ProteinModelPortal P46674
SMR P46674
BioGrid 32210
DIP DIP-2444N
IntAct P46674
MINT MINT-596858
STRING 4932.YDR159W
TCDB 3.A.22.1.1
MaxQB P46674
PaxDb P46674
EnsemblFungi [example_ID YDR159W]
GeneID 851737
KEGG sce:YDR159W
CYGD YDR159w
SGD S000002566
eggNOG COG5079
GeneTree ENSGT00530000063781
HOGENOM HOG000065955
InParanoid P46674
OMA WDRMRSI
OrthoDB EOG7VDXXJ
BioCyc YEAST:G3O-29749-MONOMER
EvolutionaryTrace P46674
NextBio 969466
PRO PR:P46674
Proteomes UP000002311
Genevestigator P46674
GO GO:0005635
GO:0070390
GO:0030029
GO:0007067
GO:0031124
GO:0006406
GO:0071033
GO:0000973
GO:0006611
GO:0006355
GO:0042274
GO:0006351
GO:0006283
InterPro IPR017173
IPR005062
IPR024293
Pfam PF12209
PF03399
PIRSF PIRSF037320

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0071033

nuclear retention of pre-mRNA at the site of transcription

PMID:18003937[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070390

transcription export complex 2

PMID:15311284[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042274

ribosomal small subunit biogenesis

PMID:19806183[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031124

mRNA 3'-end processing

PMID:18614048[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030029

actin filament-based process

PMID:2656401[5]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000001855

P

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:8799844[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006611

protein export from nucleus

PMID:10716708[7]

ECO:0000316

genetic interaction evidence used in manual assertion

P

Seeded From UniProt

Missing: with/from

involved_in

GO:0006611

protein export from nucleus

PMID:10716708[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006406

mRNA export from nucleus

PMID:12631707[8]

ECO:0000353

physical interaction evidence used in manual assertion

SGD:S000001669
SGD:S000003577
SGD:S000004650
SGD:S000005572
SGD:S000006090

P

Seeded From UniProt

complete

involved_in

GO:0006406

mRNA export from nucleus

PMID:12631707[8]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000001669
SGD:S000006090

P

Seeded From UniProt

complete

involved_in

GO:0006406

mRNA export from nucleus

PMID:12631707[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006406

mRNA export from nucleus

PMID:12411502[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006283

transcription-coupled nucleotide-excision repair

PMID:17537816[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0044614

nuclear pore cytoplasmic filaments

PMID:12631707[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000973

posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery

PMID:18003937[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070390

transcription export complex 2

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0028974
PANTHER:PTN000277436
SGD:S000002566

C

Seeded From UniProt

complete

involved_in

GO:0016973

poly(A)+ mRNA export from nucleus

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0028974
PANTHER:PTN000277436

P

Seeded From UniProt

complete

involved_in

GO:0006406

mRNA export from nucleus

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0028974
PANTHER:PTN000277436
SGD:S000002566

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1930089
PANTHER:PTN000277436
UniProtKB:O60318

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0028974
MGI:MGI:1913656
MGI:MGI:1930089
PANTHER:PTN000277435
SGD:S000002566
TAIR:locus:2056058
TAIR:locus:2082485
UniProtKB:O60318

C

Seeded From UniProt

complete

involved_in

GO:0006406

mRNA export from nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017173

P

Seeded From UniProt

complete

part_of

GO:0070390

transcription export complex 2

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017173

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

involved_in

GO:0051028

mRNA transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0509

P

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0178

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Chekanova, JA et al. (2008) Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. RNA 14 66-77 PubMed GONUTS page
  2. Fischer, T et al. (2004) Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery. Nat. Cell Biol. 6 840-8 PubMed GONUTS page
  3. Li, Z et al. (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol. 7 e1000213 PubMed GONUTS page
  4. Saguez, C et al. (2008) Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation. Mol. Cell 31 91-103 PubMed GONUTS page
  5. Novick, P et al. (1989) Suppressors of yeast actin mutations. Genetics 121 659-74 PubMed GONUTS page
  6. Bauer, A & Kölling, R (1996) The SAC3 gene encodes a nuclear protein required for normal progression of mitosis. J. Cell. Sci. 109 ( Pt 6) 1575-83 PubMed GONUTS page
  7. 7.0 7.1 Jones, AL et al. (2000) SAC3 may link nuclear protein export to cell cycle progression. Proc. Natl. Acad. Sci. U.S.A. 97 3224-9 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Lei, EP et al. (2003) Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex. Mol. Biol. Cell 14 836-47 PubMed GONUTS page
  9. Fischer, T et al. (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J. 21 5843-52 PubMed GONUTS page
  10. Gaillard, H et al. (2007) A new connection of mRNP biogenesis and export with transcription-coupled repair. Nucleic Acids Res. 35 3893-906 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page