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YEAST:SAC3
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | SAC3 (synonyms: LEP1) | |
| Protein Name(s) | Nuclear mRNA export protein SAC3
Leucine permease transcriptional regulator | |
| External Links | ||
| UniProt | P46674 | |
| EMBL | Z47805 Z50046 U35227 BK006938 | |
| PIR | S51323 | |
| RefSeq | NP_010443.3 | |
| PDB | 3FWB 3FWC 3T5V 4C31 4MBE | |
| PDBsum | 3FWB 3FWC 3T5V 4C31 4MBE | |
| ProteinModelPortal | P46674 | |
| SMR | P46674 | |
| BioGrid | 32210 | |
| DIP | DIP-2444N | |
| IntAct | P46674 | |
| MINT | MINT-596858 | |
| STRING | 4932.YDR159W | |
| TCDB | 3.A.22.1.1 | |
| MaxQB | P46674 | |
| PaxDb | P46674 | |
| EnsemblFungi | [example_ID YDR159W] | |
| GeneID | 851737 | |
| KEGG | sce:YDR159W | |
| CYGD | YDR159w | |
| SGD | S000002566 | |
| eggNOG | COG5079 | |
| GeneTree | ENSGT00530000063781 | |
| HOGENOM | HOG000065955 | |
| InParanoid | P46674 | |
| OMA | WDRMRSI | |
| OrthoDB | EOG7VDXXJ | |
| BioCyc | YEAST:G3O-29749-MONOMER | |
| EvolutionaryTrace | P46674 | |
| NextBio | 969466 | |
| PRO | PR:P46674 | |
| Proteomes | UP000002311 | |
| Genevestigator | P46674 | |
| GO | GO:0005635 GO:0070390 GO:0030029 GO:0007067 GO:0031124 GO:0006406 GO:0071033 GO:0000973 GO:0006611 GO:0006355 GO:0042274 GO:0006351 GO:0006283 | |
| InterPro | IPR017173 IPR005062 IPR024293 | |
| Pfam | PF12209 PF03399 | |
| PIRSF | PIRSF037320 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0071033 |
nuclear retention of pre-mRNA at the site of transcription |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070390 |
transcription export complex 2 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042274 |
ribosomal small subunit biogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031124 |
mRNA 3'-end processing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030029 |
actin filament-based process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000001855 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000278 |
mitotic cell cycle |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006611 |
protein export from nucleus |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0006611 |
protein export from nucleus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006406 |
mRNA export from nucleus |
ECO:0000353 |
physical interaction evidence used in manual assertion |
SGD:S000001669 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006406 |
mRNA export from nucleus |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000001669 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006406 |
mRNA export from nucleus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006406 |
mRNA export from nucleus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006283 |
transcription-coupled nucleotide-excision repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044614 |
nuclear pore cytoplasmic filaments |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000973 |
posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070390 |
transcription export complex 2 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0028974 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016973 |
poly(A)+ mRNA export from nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0028974 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006406 |
mRNA export from nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0028974 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1930089 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0028974 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006406 |
mRNA export from nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070390 |
transcription export complex 2 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051028 |
mRNA transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Chekanova, JA et al. (2008) Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. RNA 14 66-77 PubMed GONUTS page
- ↑ Fischer, T et al. (2004) Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery. Nat. Cell Biol. 6 840-8 PubMed GONUTS page
- ↑ Li, Z et al. (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol. 7 e1000213 PubMed GONUTS page
- ↑ Saguez, C et al. (2008) Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation. Mol. Cell 31 91-103 PubMed GONUTS page
- ↑ Novick, P et al. (1989) Suppressors of yeast actin mutations. Genetics 121 659-74 PubMed GONUTS page
- ↑ Bauer, A & Kölling, R (1996) The SAC3 gene encodes a nuclear protein required for normal progression of mitosis. J. Cell. Sci. 109 ( Pt 6) 1575-83 PubMed GONUTS page
- ↑ 7.0 7.1 Jones, AL et al. (2000) SAC3 may link nuclear protein export to cell cycle progression. Proc. Natl. Acad. Sci. U.S.A. 97 3224-9 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Lei, EP et al. (2003) Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex. Mol. Biol. Cell 14 836-47 PubMed GONUTS page
- ↑ Fischer, T et al. (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J. 21 5843-52 PubMed GONUTS page
- ↑ Gaillard, H et al. (2007) A new connection of mRNP biogenesis and export with transcription-coupled repair. Nucleic Acids Res. 35 3893-906 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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