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Jones, AL, Quimby, BB, Hood, JK, Ferrigno, P, Keshava, PH, Silver, PA and Corbett, AH (2000) SAC3 may link nuclear protein export to cell cycle progression. Proc. Natl. Acad. Sci. U.S.A. 97:3224-9


Selective movement of proteins between the nucleus and the cytoplasm is a regulatory mechanism exploited extensively by the eukaryotic cell. We have identified the evolutionarily conserved Sac3 protein, which was implicated previously in the regulation of mitosis [Bauer, A. & Kölling, R. (1996) J. Cell Sci. 109, 1575-1583] as a novel mediator of nuclear protein export. We show that Sac3p is localized to the nuclear pore, where it interacts with nucleoporins. Loss of SAC3 function results in a block in nuclear export of a nuclear export signal-containing reporter protein. Our results also demonstrate that SAC3 interacts genetically with the nuclear protein export factors Crm1p/Xpo1p and Yrb2p. Taken together, these data indicate a link between nuclear protein export and transition through the cell cycle.


PubMed PMC16220 Online version:10.1073/pnas.050432997


Amino Acid Sequence; Biological Transport; Calcium-Binding Proteins; Cell Cycle; Fluorescent Antibody Technique, Indirect; Fungal Proteins/metabolism; Gene Deletion; Green Fluorescent Proteins; Luminescent Proteins/genetics; Molecular Sequence Data; Nuclear Pore Complex Proteins; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Nucleocytoplasmic Transport Proteins; Porins; Protein Binding; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid



Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status

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