YEAST:MSH3

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	MSH3
Protein Name(s)	DNA mismatch repair protein MSH3 Mismatch-binding protein MBP MutS protein homolog 3
External Links
UniProt	P25336
EMBL	X64954 M96250 X59720 BK006937
PIR	S19508
RefSeq	NP_010016.2
ProteinModelPortal	P25336
SMR	P25336
BioGrid	31064
DIP	DIP-2422N
IntAct	P25336
MINT	MINT-633647
STRING	4932.YCR092C
MaxQB	P25336
PaxDb	P25336
PeptideAtlas	P25336
PRIDE	P25336
EnsemblFungi	[example_ID YCR092C]
GeneID	850454
KEGG	sce:YCR092C
CYGD	YCR092c
SGD	S000000688
eggNOG	COG0249
GeneTree	ENSGT00550000074949
HOGENOM	HOG000057130
InParanoid	P25336
KO	K08736
OMA	GYLLCIT
OrthoDB	EOG773XQH
BioCyc	YEAST:G3O-29386-MONOMER
Reactome	REACT_239457
NextBio	966078
PRO	PR:P25336
Proteomes	UP000002311
Genevestigator	P25336
GO	GO:0032302 GO:0005524 GO:0032135 GO:0000406 GO:0006310 GO:0000710 GO:0006298 GO:0006312 GO:0000735
Gene3D	3.40.1170.10 3.40.50.300
InterPro	IPR007695 IPR000432 IPR007861 IPR007696 IPR016151 IPR007860 IPR027417
Pfam	PF01624 PF05188 PF05192 PF05190 PF00488
SMART	SM00534 SM00533
SUPFAM	SSF48334 SSF52540 SSF55271
PROSITE	PS00486

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005737	cytoplasm	PMID:14562095^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14562095^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043111	replication fork arrest	PMID:27045900^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032302	MutSbeta complex	PMID:8805366^[3]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000005450	C	Seeded From UniProt	complete
enables	GO:0032135	DNA insertion or deletion binding	PMID:8805366^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0030983	mismatched DNA binding	PMID:17636021^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006312	mitotic recombination	PMID:8849883^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	PMID:15920474^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:9520271^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:8510668^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000735	removal of nonhomologous ends	PMID:9256462^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000005943	P	Seeded From UniProt	complete
involved_in	GO:0000735	removal of nonhomologous ends	PMID:9256462^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000710	meiotic mismatch repair	PMID:16702432^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0000406	double-strand/single-strand DNA junction binding	PMID:16781730^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0000404	heteroduplex DNA loop binding	PMID:16781730^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0000403	Y-form DNA binding	PMID:16781730^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0051096	positive regulation of helicase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 UniProtKB:P20585	P	Seeded From UniProt	complete
involved_in	GO:0043570	maintenance of DNA repeat elements	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 PomBase:SPAC8F11.03 UniProtKB:P20585	P	Seeded From UniProt	complete
involved_in	GO:0043111	replication fork arrest	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 SGD:S000000688	P	Seeded From UniProt	complete
enables	GO:0032357	oxidized purine DNA binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145772 UniProtKB:P20585	F	Seeded From UniProt	complete
part_of	GO:0032302	MutSbeta complex	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 SGD:S000000688 UniProtKB:P20585	C	Seeded From UniProt	complete
part_of	GO:0032300	mismatch repair complex	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779	C	Seeded From UniProt	complete
contributes_to	GO:0032143	single thymine insertion binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002260779 UniProtKB:P43246 UniProtKB:P52701	F	Seeded From UniProt	complete
contributes_to	GO:0032137	guanine/thymine mispair binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 MGI:MGI:1343961 PANTHER:PTN002260779 SGD:S000001162 SGD:S000002504 SGD:S000005450 UniProtKB:P43246 UniProtKB:P52701	F	Seeded From UniProt	complete
enables	GO:0008094	DNA-dependent ATPase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002260779 SGD:S000001162	F	Seeded From UniProt	complete
involved_in	GO:0007131	reciprocal meiotic recombination	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 PomBase:SPAC8F11.03	P	Seeded From UniProt	complete
involved_in	GO:0006312	mitotic recombination	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 SGD:S000000688	P	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 FB:FBgn0015546 MGI:MGI:101816 MGI:MGI:109519 MGI:MGI:1343961 PANTHER:PTN000145505 PomBase:SPBC19G7.01c PomBase:SPCC285.16c SGD:S000000688 SGD:S000001162 SGD:S000002504 SGD:S000005450 TAIR:locus:2095097 UniProtKB:P20585 UniProtKB:P43246 UniProtKB:P52701 WB:WBGene00003418 WB:WBGene00003422	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779 SGD:S000002504 SGD:S000005450 UniProtKB:P43246 UniProtKB:P52701	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779 SGD:S000002504 SGD:S000005450	F	Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 MGI:MGI:109519 MGI:MGI:1343961 PANTHER:PTN002260779 TAIR:locus:2095097 TAIR:locus:2131829 UniProtKB:O04716	F	Seeded From UniProt	complete
involved_in	GO:0000735	removal of nonhomologous ends	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 SGD:S000000688	P	Seeded From UniProt	complete
involved_in	GO:0000710	meiotic mismatch repair	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 SGD:S000000688	P	Seeded From UniProt	complete
enables	GO:0000406	double-strand/single-strand DNA junction binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145772 SGD:S000000688	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR007861 InterPro:IPR016151 InterPro:IPR036678	F	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR007861 InterPro:IPR016151 InterPro:IPR017261 InterPro:IPR036678	P	Seeded From UniProt	complete
enables	GO:0030983	mismatched DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR007861 InterPro:IPR016151 InterPro:IPR017261 InterPro:IPR036678	F	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
↑ Viterbo, D et al. (2016) Replication stalling and heteroduplex formation within CAG/CTG trinucleotide repeats by mismatch repair. DNA Repair (Amst.) 42 94-106 PubMed GONUTS page
↑ ^3.0 ^3.1 Habraken, Y et al. (1996) Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3. Curr. Biol. 6 1185-7 PubMed GONUTS page
↑ Harrington, JM & Kolodner, RD (2007) Saccharomyces cerevisiae Msh2-Msh3 acts in repair of base-base mispairs. Mol. Cell. Biol. 27 6546-54 PubMed GONUTS page
↑ Saparbaev, M et al. (1996) Requirement of mismatch repair genes MSH2 and MSH3 in the RAD1-RAD10 pathway of mitotic recombination in Saccharomyces cerevisiae. Genetics 142 727-36 PubMed GONUTS page
↑ Langston, LD & Symington, LS (2005) Opposing roles for DNA structure-specific proteins Rad1, Msh2, Msh3, and Sgs1 in yeast gene targeting. EMBO J. 24 2214-23 PubMed GONUTS page
↑ Lühr, B et al. (1998) Analysis of in vivo correction of defined mismatches in the DNA mismatch repair mutants msh2, msh3 and msh6 of Saccharomyces cerevisiae. Mol. Gen. Genet. 257 362-7 PubMed GONUTS page
↑ New, L et al. (1993) The yeast gene MSH3 defines a new class of eukaryotic MutS homologues. Mol. Gen. Genet. 239 97-108 PubMed GONUTS page
↑ ^9.0 ^9.1 Sugawara, N et al. (1997) Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination. Proc. Natl. Acad. Sci. U.S.A. 94 9214-9 PubMed GONUTS page
↑ Stone, JE & Petes, TD (2006) Analysis of the proteins involved in the in vivo repair of base-base mismatches and four-base loops formed during meiotic recombination in the yeast Saccharomyces cerevisiae. Genetics 173 1223-39 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Surtees, JA & Alani, E (2006) Mismatch repair factor MSH2-MSH3 binds and alters the conformation of branched DNA structures predicted to form during genetic recombination. J. Mol. Biol. 360 523-36 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14562095-1] 1.0 ^1.1 Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page

[PMID:27045900-2] Viterbo, D et al. (2016) Replication stalling and heteroduplex formation within CAG/CTG trinucleotide repeats by mismatch repair. DNA Repair (Amst.) 42 94-106 PubMed GONUTS page

[PMID:8805366-3] 3.0 ^3.1 Habraken, Y et al. (1996) Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3. Curr. Biol. 6 1185-7 PubMed GONUTS page

[PMID:17636021-4] Harrington, JM & Kolodner, RD (2007) Saccharomyces cerevisiae Msh2-Msh3 acts in repair of base-base mispairs. Mol. Cell. Biol. 27 6546-54 PubMed GONUTS page

[PMID:8849883-5] Saparbaev, M et al. (1996) Requirement of mismatch repair genes MSH2 and MSH3 in the RAD1-RAD10 pathway of mitotic recombination in Saccharomyces cerevisiae. Genetics 142 727-36 PubMed GONUTS page

[PMID:15920474-6] Langston, LD & Symington, LS (2005) Opposing roles for DNA structure-specific proteins Rad1, Msh2, Msh3, and Sgs1 in yeast gene targeting. EMBO J. 24 2214-23 PubMed GONUTS page

[PMID:9520271-7] Lühr, B et al. (1998) Analysis of in vivo correction of defined mismatches in the DNA mismatch repair mutants msh2, msh3 and msh6 of Saccharomyces cerevisiae. Mol. Gen. Genet. 257 362-7 PubMed GONUTS page

[PMID:8510668-8] New, L et al. (1993) The yeast gene MSH3 defines a new class of eukaryotic MutS homologues. Mol. Gen. Genet. 239 97-108 PubMed GONUTS page

[PMID:9256462-9] 9.0 ^9.1 Sugawara, N et al. (1997) Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination. Proc. Natl. Acad. Sci. U.S.A. 94 9214-9 PubMed GONUTS page

[PMID:16702432-10] Stone, JE & Petes, TD (2006) Analysis of the proteins involved in the in vivo repair of base-base mismatches and four-base loops formed during meiotic recombination in the yeast Saccharomyces cerevisiae. Genetics 173 1223-39 PubMed GONUTS page

[PMID:16781730-11] 11.0 ^11.1 ^11.2 Surtees, JA & Alani, E (2006) Mismatch repair factor MSH2-MSH3 binds and alters the conformation of branched DNA structures predicted to form during genetic recombination. J. Mol. Biol. 360 523-36 PubMed GONUTS page

[PMID:21873635-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:MSH3

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