XENLA:STA31

Species (Taxon ID)	Xenopus laevis (African clawed frog). (8355)
Gene Name(s)	stat3.1 (synonyms: stat3 (ECO:0000303 with PMID:10642787^[1]))
Protein Name(s)	Signal transducer and activator of transcription 3.1 Protein Stat3 (ECO:0000250 with UniProtKB:P40763) Xstat3 (ECO:0000303 with PMID:10642787^[1])
External Links
UniProt	Q9PVX8
EMBL	AB017701 BC169718 BC169720
RefSeq	NP_001090202.1
UniGene	Xl.57141
ProteinModelPortal	Q9PVX8
SMR	Q9PVX8
PRIDE	Q9PVX8
GeneID	779100
KEGG	xla:779100
CTD	779100
Xenbase	XB-GENE-865436
KO	K04692
GO	GO:0005737 GO:0005634 GO:0005886 GO:0005509 GO:0003677 GO:0046983 GO:0019901 GO:0043565 GO:0003700 GO:0004871 GO:0042755 GO:0001754 GO:0042593 GO:0060397 GO:0001707 GO:0014033 GO:0045893 GO:0006357 GO:0019953 GO:0001659 GO:0006351
Gene3D	1.10.238.10 1.10.532.10 1.20.1050.20 2.60.40.630 3.30.505.10
InterPro	IPR011992 IPR008967 IPR000980 IPR001217 IPR013800 IPR015988 IPR013801 IPR012345 IPR013799
PANTHER	PTHR11801
Pfam	PF00017 PF01017 PF02864 PF02865
SMART	SM00252 SM00964
SUPFAM	SSF47655 SSF48092 SSF49417 SSF55550
PROSITE	PS50001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P	Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	F	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10642787^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:10642787^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P	Seeded From UniProt	complete
involved_in	GO:0019953	sexual reproduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:15004007^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8QGV6	F	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	F	Seeded From UniProt	complete
involved_in	GO:0014033	neural crest cell differentiation	PMID:18710660^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	F	Seeded From UniProt	complete
involved_in	GO:0001754	eye photoreceptor cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P	Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	PMID:15004007^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013801	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217 InterPro:IPR008967	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217 InterPro:IPR008967 InterPro:IPR013799 InterPro:IPR013800 InterPro:IPR015988	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217 InterPro:IPR013799 InterPro:IPR013800 InterPro:IPR015988	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Nishinakamura, R et al. (1999) Activation of Stat3 by cytokine receptor gp130 ventralizes Xenopus embryos independent of BMP-4. Dev. Biol. 216 481-90 PubMed GONUTS page
↑ ^2.0 ^2.1 Ohkawara, B et al. (2004) Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. Genes Dev. 18 381-6 PubMed GONUTS page
↑ Nichane, M et al. (2008) Hairy2 functions through both DNA-binding and non DNA-binding mechanisms at the neural plate border in Xenopus. Dev. Biol. 322 368-80 PubMed GONUTS page

[PMID:10642787-1] 1.0 ^1.1 ^1.2 ^1.3 Nishinakamura, R et al. (1999) Activation of Stat3 by cytokine receptor gp130 ventralizes Xenopus embryos independent of BMP-4. Dev. Biol. 216 481-90 PubMed GONUTS page

[PMID:15004007-2] 2.0 ^2.1 Ohkawara, B et al. (2004) Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. Genes Dev. 18 381-6 PubMed GONUTS page

[PMID:18710660-3] Nichane, M et al. (2008) Hairy2 functions through both DNA-binding and non DNA-binding mechanisms at the neural plate border in Xenopus. Dev. Biol. 322 368-80 PubMed GONUTS page

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XENLA:STA31

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