XENLA:FZD7A

Species (Taxon ID)	Xenopus laevis (African clawed frog). (8355)
Gene Name(s)	fzd7-a (synonyms: fz7-a)
Protein Name(s)	Frizzled-7-A Fz-7-A Xfz7-A
External Links
UniProt	Q9PUK8
EMBL	AF039215 AJ243323 AF179213 AF114151
RefSeq	NP_001079354.1
UniGene	Xl.633
ProteinModelPortal	Q9PUK8
SMR	Q9PUK8
IntAct	Q9PUK8
MINT	MINT-4821083
GeneID	378787
KEGG	xla:378787
CTD	8324
Xenbase	XB-GENE-483735
HOVERGEN	HBG006977
KO	K02432
GO	GO:0016021 GO:0005886 GO:0004930 GO:0045545 GO:0042813 GO:0017147 GO:0060070 GO:0060027 GO:0009950 GO:0001707 GO:0045944 GO:0008104 GO:0048729 GO:0016055
Gene3D	1.10.2000.10
InterPro	IPR000539 IPR015526 IPR020067 IPR026552 IPR017981
PANTHER	PTHR11309 PTHR11309:SF31
Pfam	PF01534 PF01392
PRINTS	PR00489
SMART	SM00063
SUPFAM	SSF63501
PROSITE	PS50038 PS50261

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:10906785^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P51142	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10906785^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P51142	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:11477687^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:16604063^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:10862746^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:10727861^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048729	tissue morphogenesis	PMID:15272309^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O93509	P	Seeded From UniProt	complete
enables	GO:0045545	syndecan binding	PMID:16604063^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q1AGV6	F	Seeded From UniProt	complete
enables	GO:0045545	syndecan binding	PMID:16604063^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q1AGV7	F	Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:10862746^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49893	F	Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:16274967^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49893	F	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:11291855^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P31286	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:10906785^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P51142	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:10862746^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49893	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:10990458^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P31286	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:10751186^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49893	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:10751186^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P31291	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:10751186^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P31286	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:10727861^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P31291	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:11477687^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:16604063^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:10969734^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:10727861^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009950	dorsal/ventral axis specification	PMID:10751186^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009950	dorsal/ventral axis specification	PMID:11477687^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008104	protein localization	PMID:10906785^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P51142	P	Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	PMID:10751186^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	F	Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000539 InterPro:IPR017981	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000539	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	C	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026552	P	Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026552	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-XLA-4568832	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Medina, A & Steinbeisser, H (2000) Interaction of Frizzled 7 and Dishevelled in Xenopus. Dev. Dyn. 218 671-80 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Sumanas, S & Ekker, SC (2001) Xenopus frizzled-7 morphant displays defects in dorsoventral patterning and convergent extension movements during gastrulation. Genesis 30 119-22 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Muñoz, R et al. (2006) Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos. Nat. Cell Biol. 8 492-500 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Djiane, A et al. (2000) Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. Development 127 3091-100 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Medina, A et al. (2000) Xenopus frizzled 7 can act in canonical and non-canonical Wnt signaling pathways: implications on early patterning and morphogenesis. Mech. Dev. 92 227-37 PubMed GONUTS page
↑ Medina, A et al. (2004) Xenopus paraxial protocadherin has signaling functions and is involved in tissue separation. EMBO J. 23 3249-58 PubMed GONUTS page
↑ Shibata, M et al. (2005) Role of crescent in convergent extension movements by modulating Wnt signaling in early Xenopus embryogenesis. Mech. Dev. 122 1322-39 PubMed GONUTS page
↑ Swain, RK et al. (2001) Functional analysis of the Xenopus frizzled 7 protein domains using chimeric receptors. Int. J. Dev. Biol. 45 259-64 PubMed GONUTS page
↑ Umbhauer, M et al. (2000) The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling. EMBO J. 19 4944-54 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Sumanas, S et al. (2000) The putative wnt receptor Xenopus frizzled-7 functions upstream of beta-catenin in vertebrate dorsoventral mesoderm patterning. Development 127 1981-90 PubMed GONUTS page
↑ Brown, JD et al. (2000) The maternal Xenopus beta-catenin signaling pathway, activated by frizzled homologs, induces goosecoid in a cell non-autonomous manner. Dev. Growth Differ. 42 347-57 PubMed GONUTS page

[PMID:10906785-1] 1.0 ^1.1 ^1.2 ^1.3 Medina, A & Steinbeisser, H (2000) Interaction of Frizzled 7 and Dishevelled in Xenopus. Dev. Dyn. 218 671-80 PubMed GONUTS page

[PMID:11477687-2] 2.0 ^2.1 ^2.2 Sumanas, S & Ekker, SC (2001) Xenopus frizzled-7 morphant displays defects in dorsoventral patterning and convergent extension movements during gastrulation. Genesis 30 119-22 PubMed GONUTS page

[PMID:16604063-3] 3.0 ^3.1 ^3.2 ^3.3 Muñoz, R et al. (2006) Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos. Nat. Cell Biol. 8 492-500 PubMed GONUTS page

[PMID:10862746-4] 4.0 ^4.1 ^4.2 Djiane, A et al. (2000) Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. Development 127 3091-100 PubMed GONUTS page

[PMID:10727861-5] 5.0 ^5.1 ^5.2 Medina, A et al. (2000) Xenopus frizzled 7 can act in canonical and non-canonical Wnt signaling pathways: implications on early patterning and morphogenesis. Mech. Dev. 92 227-37 PubMed GONUTS page

[PMID:15272309-6] Medina, A et al. (2004) Xenopus paraxial protocadherin has signaling functions and is involved in tissue separation. EMBO J. 23 3249-58 PubMed GONUTS page

[PMID:16274967-7] Shibata, M et al. (2005) Role of crescent in convergent extension movements by modulating Wnt signaling in early Xenopus embryogenesis. Mech. Dev. 122 1322-39 PubMed GONUTS page

[PMID:11291855-8] Swain, RK et al. (2001) Functional analysis of the Xenopus frizzled 7 protein domains using chimeric receptors. Int. J. Dev. Biol. 45 259-64 PubMed GONUTS page

[PMID:10990458-9] Umbhauer, M et al. (2000) The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling. EMBO J. 19 4944-54 PubMed GONUTS page

[PMID:10751186-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Sumanas, S et al. (2000) The putative wnt receptor Xenopus frizzled-7 functions upstream of beta-catenin in vertebrate dorsoventral mesoderm patterning. Development 127 1981-90 PubMed GONUTS page

[PMID:10969734-11] Brown, JD et al. (2000) The maternal Xenopus beta-catenin signaling pathway, activated by frizzled homologs, induces goosecoid in a cell non-autonomous manner. Dev. Growth Differ. 42 347-57 PubMed GONUTS page

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XENLA:FZD7A

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