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PMID:15272309

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Citation

Medina, A, Swain, RK, Kuerner, KM and Steinbeisser, H (2004) Xenopus paraxial protocadherin has signaling functions and is involved in tissue separation. EMBO J. 23:3249-58

Abstract

Protocadherins have homophilic adhesion properties and mediate selective cell-cell adhesion and cell sorting. Knockdown of paraxial protocadherin (PAPC) function in the Xenopus embryo impairs tissue separation, a process that regulates separation of cells of ectodermal and mesodermal origin during gastrulation. We show that PAPC can modulate the activity of the Rho GTPase and c-jun N-terminal kinase, two regulators of the cytoskeletal architecture and effectors of the planar cell polarity pathway. This novel signaling function of PAPC is essential for the regulation of tissue separation. In addition, PAPC can interact with the Xenopus Frizzled 7 receptor, and both proteins contribute to the development of separation behavior by activating Rho and protein kinase Calpha.

Links

PubMed PMC514504 Online version:10.1038/sj.emboj.7600329

Keywords

Animals; Body Patterning; Cadherins/genetics; Cadherins/metabolism; Gastrula/metabolism; JNK Mitogen-Activated Protein Kinases/metabolism; Mesoderm/metabolism; Protein Binding; Receptors, G-Protein-Coupled/genetics; Receptors, G-Protein-Coupled/metabolism; Signal Transduction; Xenopus Proteins/genetics; Xenopus Proteins/metabolism; Xenopus laevis/embryology; Xenopus laevis/genetics; Xenopus laevis/metabolism; rho GTP-Binding Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

XENLA:O93509

enables

GO:0005109: frizzled binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9PUK8

F

Seeded From UniProt

complete

XENLA:FZD7A

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:O93509

F

Seeded From UniProt

complete

XENLA:FZD7A

involved_in

GO:0048729: tissue morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

UniProtKB:O93509

P

Seeded From UniProt

complete


See also

References

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