User:Wierzb16

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
updatedbyinstructor	MOUSE:KMT2A	2012-04-11 23:00:46 CDT	GO:0060216 definitive hemopoiesis (P)	PMID:15556871	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 2C shows the failure of MII-deficient cells to give rise to hematopoietic colonies. Figure 2 A and B shows the normal development of cells for MII and MII-deficient cells, indicating normal differentiation. Thus, MII-deficient cells develop normally until hematopoietic differentiation. The lack of differentiation results in a failure to develop a hematopoietic center in the body.	challenge
requireschanges	?	2012-04-12 11:34:27 CDT	GO:0042476 odontogenesis (Figure 2 depicts the phenotypic differences between an IRF6 mutant and a wild type mouse. The incisors are evaginated and enlarged in the IRF6 mutant, indicating IRF6 plays a role in the development of the teeth. )	PMID:22366192	IMP: Inferred from Mutant Phenotype		challenge
acceptable	MOUSE:MK08	2012-04-14 12:10:14 CDT	GO:0001764 neuron migration (P)	PMID:21297631	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 2E, JNK1 deficient neurons migrate faster than wild type neurons, as 3 times as many JNK deficient cells had migrated. Figure 7E supports this, showing that JNK deficient cells migrate at a faster speed in a time lapse study. JNK1 is involved in migration of neurons.	challenge
acceptable	MOUSE:MK08	2012-04-14 12:31:10 CDT	GO:0048813 dendrite morphogenesis (P)	PMID:16000625	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 4 shows that inhibition of JNK1 results in shorter and more numerous dendritic processes. Figures 7 and 8 support JNK1 involvement in the development of the shape and size of the dendritic processes by pictures and analyzation of the dendrites.	challenge
requireschanges	MOUSE:MK08	2012-04-14 13:05:12 CDT	GO:0004708 MAP kinase kinase activity (F)	PMID:12689591	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 5B shows that JNK1 efficiently phosphorylates MAP and 5D shows that it is specific. At low concentrations, JNK1 is a predominant MAP2 kinase. In Figure 6A, JNK1 deficient mice displayed 3 fold lower labelling of MAP2 and in 6B MAP2 polypeptides are significantly lowered in JNK1 deficient mice. JNK1 is an important MAP2 kinase.	challenge

acceptable:2
unacceptable:0
requires_changes:2
flagged:0

Annotations challenged by Wierzb16

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
requireschanges	Co227488, Team Har Gobind Khorana	CAEEL:CUP4	GO:0005216 - monoatomic ion channel activity (F)	PMID:19783783	ECO:0000269 experimental evidence used in manual assertion	challenge	C: 1

0 annotations fixed by Wierzb16

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
requireschanges	?	2012-03-29 12:48:24 CDT	GO:0042981 regulation of apoptotic process (In Figure 1 (A, B, and C), the anti-CD147 testes show significant loss in size, weight, and internal cell counts. This is evidenced by comparison to testes with full expression of CD147 which are full, pink, larger, and have complete cell structures within. When CD147 is removed, apoptosis is not regulated and spermatocytes freely die within the testes.)	PMID:22451502	IMP: Inferred from Mutant Phenotype		challenge

acceptable:0
unacceptable:0
requires_changes:1
flagged:0

Annotations challenged by Wierzb16

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history

0 annotations fixed by Wierzb16