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PMID:22451502
| Citation |
Chen, H, Fok, KL, Jiang, X, Jiang, J, Chen, Z, Gui, Y, Chan, HC and Cai, Z (2012) CD147 regulates apoptosis in mouse spermatocytes but not spermatogonia. Hum. Reprod. 27:1568-76 |
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| Abstract |
Spermatogenesis is maintained by a dynamic balance between germ cell proliferation and apoptosis. Previous study has demonstrated that CD147 knockout mice are infertile with arrested germ cells. However, the question of whether and how CD147 may be involved in the apoptotic process during spermatogenesis remains elusive. The aim of this study was to evaluate the role of CD147 in the regulation of germ cell apoptosis in mice. |
| Links |
PubMed Online version:10.1093/humrep/des050 |
| Keywords |
Animals; Antibodies, Monoclonal/administration & dosage; Antigens, CD147/immunology; Antigens, CD147/physiology; Apoptosis/physiology; Caspase 3/metabolism; Cell Line; Enzyme Activation; In Situ Nick-End Labeling; Male; Mice; Mice, SCID; Organ Size/drug effects; Poly(ADP-ribose) Polymerases/metabolism; Signal Transduction/physiology; Spermatocytes/physiology; Spermatogonia/physiology; Testis/anatomy & histology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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See also
References
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