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CAEEL:CUP4

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) cup-4
Protein Name(s) Acetylcholine receptor-like protein cup-4

Coelomocyte uptake defective protein 4

External Links
UniProt P34271
EMBL AY611497
FO080276
PIR S44741
RefSeq NP_498710.2
UniGene Cel.19985
ProteinModelPortal P34271
SMR P34271
STRING 6239.C02C2.3
PaxDb P34271
PRIDE P34271
EnsemblMetazoa C02C2.3
GeneID 176104
KEGG cel:CELE_C02C2.3
UCSC C02C2.3
CTD 176104
WormBase C02C2.3
eggNOG NOG325377
GeneTree ENSGT00390000014985
HOGENOM HOG000112082
InParanoid P34271
OMA SAHVIIQ
OrthoDB EOG7QNVQV
PhylomeDB P34271
Reactome REACT_210579
NextBio 891132
Proteomes UP000001940
GO GO:0031410
GO:0030659
GO:0016021
GO:0015464
GO:0005230
GO:0005216
GO:0006897
GO:0034220
GO:0030100
GO:0007268
Gene3D 2.70.170.10
InterPro IPR006202
IPR006201
IPR018000
PANTHER PTHR18945
Pfam PF02931
SUPFAM SSF63712
PROSITE PS00236

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005216

ion channel activity

PMID:19783783[1]

ECO:0000269

F

Figure 3D suggests resistance to oxidative resistance at the membrane level. Also, the author states "These findings indicate that NLP-7 and CUP-4 function in the same pathway under DR. Other SKN-1-dependent pathways might be activated by dietary restriction (DR)" .

complete
CACAO 4465

involved_in

GO:0008340

determination of adult lifespan

PMID:19783783[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q94125

P

Seeded From UniProt

complete

involved_in

GO:0008340

determination of adult lifespan

PMID:19783783[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P48376

P

Seeded From UniProt

complete

involved_in

GO:1901046

positive regulation of oviposition

PMID:19783783[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008340

determination of adult lifespan

PMID:19783783[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008340

determination of adult lifespan

PMID:19783783[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P34707
UniProtKB:Q19569

P

Seeded From UniProt

complete

involved_in

GO:0061771

response to caloric restriction

PMID:19783783[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901562

response to paraquat

PMID:19783783[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P34707
UniProtKB:Q19569

P

Seeded From UniProt

complete

involved_in

GO:1901562

response to paraquat

PMID:19783783[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061771

response to caloric restriction

PMID:19783783[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

PMID:15936276[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006897

endocytosis

PMID:11560892[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030659

cytoplasmic vesicle membrane

PMID:15936276[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030100

regulation of endocytosis

PMID:15936276[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0015464

acetylcholine receptor activity

PMID:15936276[2]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0050877

nervous system process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87888
PANTHER:PTN000434994
UniProtKB:P11230
UniProtKB:P17787
UniProtKB:P43681

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95747
PANTHER:PTN000434994
UniProtKB:G5EDF1
UniProtKB:P11230
WB:WBGene00006765
WB:WBGene00006774

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95747
PANTHER:PTN000434994
RGD:2351
RGD:621544
WB:WBGene00000042
WB:WBGene00002974
WB:WBGene00006765
WB:WBGene00006774

C

Seeded From UniProt

complete

involved_in

GO:0042391

regulation of membrane potential

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87885
MGI:MGI:87887
MGI:MGI:87888
MGI:MGI:87890
MGI:MGI:87891
MGI:MGI:87892
MGI:MGI:87893
MGI:MGI:87894
MGI:MGI:87895
MGI:MGI:95747
MGI:MGI:95751
MGI:MGI:99779
PANTHER:PTN000434994
RGD:2348
UniProtKB:P02708
UniProtKB:P23415

P

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95613
PANTHER:PTN000434994
UniProtKB:P23416
UniProtKB:P36544
UniProtKB:Q401N2
WB:WBGene00000055
WB:WBGene00002974
WB:WBGene00006797

P

Seeded From UniProt

complete

involved_in

GO:0007268

chemical synaptic transmission

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003011
FB:FBgn0086778
MGI:MGI:103156
MGI:MGI:95613
MGI:MGI:95623
MGI:MGI:95747
PANTHER:PTN000434994
RGD:2648
RGD:61859
RGD:61901
UniProtKB:P48167
WB:WBGene00000050
WB:WBGene00000054

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000434994
UniProtKB:P11230
UniProtKB:P17787
UniProtKB:P30926
UniProtKB:P32297
UniProtKB:P36544
UniProtKB:P43681
UniProtKB:Q15822

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1861899
MGI:MGI:95623
MGI:MGI:95750
PANTHER:PTN000434994
RGD:2649
RGD:2650
RGD:61855
RGD:61861
RGD:621229
UniProtKB:O75311
UniProtKB:P23415
UniProtKB:P23416
UniProtKB:P28472
UniProtKB:P48167
UniProtKB:Q9UGM1
WB:WBGene00000955
WB:WBGene00001133
WB:WBGene00001591
WB:WBGene00001592

C

Seeded From UniProt

complete

contributes_to

GO:0005230

extracellular ligand-gated ion channel activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000434994
WB:WBGene00000043
WB:WBGene00001512
WB:WBGene00003386
WB:WBGene00006774
WB:WBGene00012857
WB:WBGene00017375

F

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006201

F

Seeded From UniProt

complete

enables

GO:0005216

ion channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006201

F

Seeded From UniProt

complete

enables

GO:0005230

extracellular ligand-gated ion channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006202
InterPro:IPR036734

F

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006202
InterPro:IPR036734

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006201
InterPro:IPR006202
InterPro:IPR036734

C

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006201

P

Seeded From UniProt

complete

enables

GO:0005216

ion channel activity

PMID:15936276[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0006897

endocytosis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0254

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

part_of

GO:0030659

cytoplasmic vesicle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0089

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Park, SK et al. (2010) Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. FASEB J. 24 383-92 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Patton, A et al. (2005) Endocytosis function of a ligand-gated ion channel homolog in Caenorhabditis elegans. Curr. Biol. 15 1045-50 PubMed GONUTS page
  3. Fares, H & Greenwald, I (2001) Genetic analysis of endocytosis in Caenorhabditis elegans: coelomocyte uptake defective mutants. Genetics 159 133-45 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page