GONUTS has been updated to MW1.29.2. Most things seem to be working but be sure to report problems.

It is now the 3rd OPEN Period for CACAO Phage Hunters S2018! It will end on Friday July 20, 2018 at 05:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

CAEEL:CUP4

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) cup-4
Protein Name(s) Acetylcholine receptor-like protein cup-4

Coelomocyte uptake defective protein 4

External Links
UniProt P34271
EMBL AY611497
FO080276
PIR S44741
RefSeq NP_498710.2
UniGene Cel.19985
ProteinModelPortal P34271
SMR P34271
STRING 6239.C02C2.3
PaxDb P34271
PRIDE P34271
EnsemblMetazoa C02C2.3
GeneID 176104
KEGG cel:CELE_C02C2.3
UCSC C02C2.3
CTD 176104
WormBase C02C2.3
eggNOG NOG325377
GeneTree ENSGT00390000014985
HOGENOM HOG000112082
InParanoid P34271
OMA SAHVIIQ
OrthoDB EOG7QNVQV
PhylomeDB P34271
Reactome REACT_210579
NextBio 891132
Proteomes UP000001940
GO GO:0031410
GO:0030659
GO:0016021
GO:0015464
GO:0005230
GO:0005216
GO:0006897
GO:0034220
GO:0030100
GO:0007268
Gene3D 2.70.170.10
InterPro IPR006202
IPR006201
IPR018000
PANTHER PTHR18945
Pfam PF02931
SUPFAM SSF63712
PROSITE PS00236

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005216

ion channel activity

PMID:15936276[1]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0005230

extracellular ligand-gated ion channel activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006202

F

Seeded From UniProt

complete

GO:0005887

integral component of plasma membrane

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001450060

C

Seeded From UniProt

complete

GO:0006810

transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006202

P

Seeded From UniProt

complete

GO:0006810

transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

Seeded From UniProt

complete

GO:0006811

ion transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006201

P

Seeded From UniProt

complete

GO:0006811

ion transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

GO:0006897

endocytosis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0254

P

Seeded From UniProt

complete

GO:0005216

ion channel activity

PMID:19783783[2]

EXP: Inferred from Experiment

F

Figure 3D suggests resistance to oxidative resistance at the membrane level. Also, the author states "These findings indicate that NLP-7 and CUP-4 function in the same pathway under DR. Other SKN-1-dependent pathways might be activated by dietary restriction (DR)" .

complete
CACAO 4465

GO:0006897

endocytosis

PMID:11560892[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007165

signal transduction

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001450060

P

Seeded From UniProt

complete

GO:0007268

synaptic transmission

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001450060

P

Seeded From UniProt

complete

GO:0015464

acetylcholine receptor activity

PMID:15936276[1]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006202

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006201

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0030100

regulation of endocytosis

PMID:15936276[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030659

cytoplasmic vesicle membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0089

C

Seeded From UniProt

complete

GO:0030659

cytoplasmic vesicle membrane

PMID:15936276[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

GO:0031410

cytoplasmic vesicle

PMID:15936276[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0042391

regulation of membrane potential

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001450060

P

Seeded From UniProt

complete

GO:0043005

neuron projection

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001450060

C

Seeded From UniProt

complete

GO:0045202

synapse

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001450060

C

Seeded From UniProt

complete

GO:0050877

neurological system process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001450060

P

Seeded From UniProt

complete

GO:1902476

chloride transmembrane transport

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001055382

P

Seeded From UniProt

complete

contributes_to

GO:0005230

extracellular ligand-gated ion channel activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001450060

F

Seeded From UniProt

complete

contributes_to

GO:0005254

chloride channel activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001055382

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Patton, A et al. (2005) Endocytosis function of a ligand-gated ion channel homolog in Caenorhabditis elegans. Curr. Biol. 15 1045-50 PubMed GONUTS page
  2. Park, SK et al. (2010) Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. FASEB J. 24 383-92 PubMed GONUTS page
  3. Fares, H & Greenwald, I (2001) Genetic analysis of endocytosis in Caenorhabditis elegans: coelomocyte uptake defective mutants. Genetics 159 133-45 PubMed GONUTS page