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User:Vinodnov

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SUPER BOWL (Round 5)

My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
requireschanges?2012-04-13 20:49:53 CDTGO:0043066 negative regulation of apoptotic process (Figure 1A illustrates that the number of cell with apotosis inducer NMDA were significantly reduced by APC. Figures 3B and 3F show APC reduces levels of apoptosis dependent protein p53 by half in NMDA-treated neurons.)PMID:14980205IDA: Inferred from Direct Assay
challenge
requireschanges?2012-04-13 21:24:49 CDTGO:0007051 spindle organization (Figure 8B illustrates PLK1 inhibitor BI 2536 results in defects of mitotic spindle organization and a delay in mitotic progression.)PMID:22479190IDA: Inferred from Direct Assay
challenge
requireschanges?2012-04-13 21:41:14 CDTGO:0007051 spindle organization (Figure 6C illustrates mitotic cells in Tcof1 knock-down cultures contained abnormal mitotic spindle and chromosome alignment. Figure 7D illustrates cells lacking Tcof1 showed abnormality in chromosome alignment.)PMID:22479190IDA: Inferred from Direct Assay
challenge
requireschanges?2012-04-13 23:14:00 CDTGO:0008283 cell proliferation (Figure 6 illustrates mutant embryos lacking Pes formed abnormal blastomeres inhibiting the embryos to proliferate past the early stages of development.)PMID:12237316IMP: Inferred from Mutant Phenotype
challenge
updatedbyinstructorYEAST:HST12012-04-14 18:07:17 CDTGO:0070623 regulation of thiamine biosynthetic process (P)PMID:20439498ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 7A illusterates an increase in intracellular thiamine levels in the mutant Hst1 representing that cellular thiamine homeostasis in yeast requires Hst1.

challenge
requireschanges?2012-04-14 18:34:05 CDTGO:0090180 positive regulation of thiamine biosynthetic process (Figure 1 illustrates α-galactosidase activity in pAS2-PDC2 yeast cells and ecially when the cells were grown in low-thiamin medium.Indicating that Pdc2p serves as a transactivation activator in response to thiamin starvation.)PMID:19013460IDA: Inferred from Direct Assay
challenge

acceptable:0
unacceptable:0
requires_changes:5
flagged:0

Annotations challenged by Vinodnov

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history
requireschangesKuenzels,
Team Celestial Seasonings
MYCTU:DEVRGO:0071456 - cellular response to hypoxia (P)PMID:12694625ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 1

0 annotations fixed by Vinodnov


MSU Internal

My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
requireschanges?2012-04-01 12:33:23 CDTGO:0006979 response to oxidative stress (Figure 1 showed Fibroblasts exposed to 6 hours of oxidants H2o2, paraquat , cadmium and hemin showed an increased regulation of Hmox1. Lanes 3 and 12 exposed to hemin and paraquat showed cells with strongest induction.)PMID:9380736IDA: Inferred from Direct Assay
challenge

acceptable:0
unacceptable:0
requires_changes:1
flagged:0

Annotations challenged by Vinodnov

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history
requireschangesKuenzels,
Team Celestial Seasonings
MYCTU:DEVRGO:0071456 - cellular response to hypoxia (P)PMID:12694625ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 1

0 annotations fixed by Vinodnov