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MYCTU:DEVR

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Species (Taxon ID) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332)
Gene Name(s) devR (synonyms: dosR)
Protein Name(s) Transcriptional regulatory protein DevR (DosR)
External Links
UniProt P9WMF9
EMBL U22037
AL123456
PIR F70645
RefSeq NP_217649.1
YP_006516595.1
PDB 1ZLJ
1ZLK
3C3W
3C57
PDBsum 1ZLJ
1ZLK
3C3W
3C57
ProteinModelPortal P9WMF9
SMR P9WMF9
ChEMBL CHEMBL6064
GeneID 13317940
888842
KEGG mtu:Rv3133c
mtv:RVBD_3133c
TubercuList Rv3133c
KO K07695
OMA HQGNANF
PhylomeDB P9WMF9
Proteomes UP000001584
GO GO:0005618
GO:0005829
GO:0005615
GO:0044161
GO:0072493
GO:0005886
GO:0003677
GO:0003700
GO:0022611
GO:0009405
GO:0000160
GO:0045893
GO:0019217
GO:0080134
GO:0001666
GO:0006351
Gene3D 1.10.10.10
InterPro IPR011006
IPR016032
IPR001789
IPR000792
IPR011991
Pfam PF00196
PF00072
PRINTS PR00038
SMART SM00421
SM00448
SUPFAM SSF46894
SSF52172
PROSITE PS00622
PS50043
PS50110

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0071456

cellular response to hypoxia

PMID:12694625[1]

ECO:0000315

P

Figure 5B demonstrates that DosR (Asp-54Glu) mutants have significantly reduced hypoxic gene induction compared to the wild-type DosR.

complete
CACAO 4107

part_of

GO:0005886

plasma membrane

PMID:15525680[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:14532352[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15525680[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

PMID:20825248[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0072493

host cell endosome lumen

PMID:10970762[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:18502855[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P9WJY7

P

Seeded From UniProt

complete

involved_in

GO:0022611

dormancy process

PMID:20023019[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

PMID:14907770[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:10970762[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:10970762[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:12694625[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:18502855[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

PMID:12694625[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

PMID:11416222[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:19228590[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000160

phosphorelay signal transduction system

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001789

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016032

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000792
InterPro:IPR016032

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0000160

phosphorelay signal transduction system

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0902

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0044161

host cell cytoplasmic vesicle

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1036
UniProtKB-SubCell:SL-0386

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Park, HD et al. (2003) Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis. Mol. Microbiol. 48 833-43 PubMed GONUTS page
  2. ↑ 2.0 2.1 Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
  3. ↑ Gu, S et al. (2003) Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol. Cell Proteomics 2 1284-96 PubMed GONUTS page
  4. ↑ Wolfe, LM et al. (2010) Proteomic definition of the cell wall of Mycobacterium tuberculosis. J. Proteome Res. 9 5816-26 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Dasgupta, N et al. (2000) Characterization of a two-component system, devR-devS, of Mycobacterium tuberculosis. Tuber. Lung Dis. 80 141-59 PubMed GONUTS page
  6. ↑ 6.0 6.1 Chauhan, S & Tyagi, JS (2008) Interaction of DevR with multiple binding sites synergistically activates divergent transcription of narK2-Rv1738 genes in Mycobacterium tuberculosis. J. Bacteriol. 190 5394-403 PubMed GONUTS page
  7. ↑ Leistikow, RL et al. (2010) The Mycobacterium tuberculosis DosR regulon assists in metabolic homeostasis and enables rapid recovery from nonrespiring dormancy. J. Bacteriol. 192 1662-70 PubMed GONUTS page
  8. ↑ KEARNEY, EB & ENGLARD, S (1951) The enzymatic phosphorylation of riboflavin. J. Biol. Chem. 193 821-34 PubMed GONUTS page
  9. ↑ Sherman, DR et al. (2001) Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallin. Proc. Natl. Acad. Sci. U.S.A. 98 7534-9 PubMed GONUTS page
  10. ↑ Guo, M et al. (2009) Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 19 1301-8 PubMed GONUTS page
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