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YEAST:HST1
Contents
Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
Gene Name(s) | HST1 | |
Protein Name(s) | NAD-dependent protein deacetylase HST1
Homologous to SIR2 protein 1 Regulatory protein SIR2 homolog 1 | |
External Links | ||
UniProt | P53685 | |
EMBL | U39041 L47120 Z74810 BK006948 | |
PIR | S59698 | |
RefSeq | NP_014573.1 | |
ProteinModelPortal | P53685 | |
SMR | P53685 | |
BioGrid | 34333 | |
DIP | DIP-6757N | |
IntAct | P53685 | |
MINT | MINT-639447 | |
STRING | 4932.YOL068C | |
MaxQB | P53685 | |
PaxDb | P53685 | |
PeptideAtlas | P53685 | |
EnsemblFungi | [example_ID YOL068C] | |
GeneID | 854086 | |
KEGG | sce:YOL068C | |
CYGD | YOL068c | |
SGD | S000005429 | |
eggNOG | COG0846 | |
GeneTree | ENSGT00740000115330 | |
HOGENOM | HOG000191845 | |
InParanoid | P53685 | |
KO | K11121 | |
OrthoDB | EOG7MWH64 | |
BioCyc | YEAST:G3O-33473-MONOMER | |
Reactome | REACT_205607 | |
SABIO-RK | P53685 | |
NextBio | 975731 | |
Proteomes | UP000002311 | |
Genevestigator | P53685 | |
GO | GO:0034967 GO:0070403 GO:0017136 GO:0045129 GO:0008270 GO:0006342 GO:0016575 GO:0045950 GO:0030435 GO:0006351 | |
Gene3D | 3.30.1600.10 3.40.50.1220 | |
InterPro | IPR029035 IPR007654 IPR003000 IPR026591 IPR026590 | |
PANTHER | PTHR11085 | |
Pfam | PF04574 PF02146 | |
SUPFAM | SSF52467 | |
PROSITE | PS50305 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0070623 |
regulation of thiamine biosynthetic process |
ECO:0000315 |
P |
Figure 7A illusterates an increase in intracellular thiamine levels in the mutant Hst1 representing that cellular thiamine homeostasis in yeast requires Hst1. |
complete | |||||
involved_in |
GO:0030466 |
chromatin silencing at silent mating-type cassette |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000002200,SGD:S000002718 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070623 |
regulation of thiamine biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016575 |
histone deacetylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_direct_input:(UniProtKB:P02309) |
Seeded From UniProt |
complete | ||
enables |
GO:0017136 |
NAD-dependent histone deacetylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(UniProtKB:P02309) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045950 |
negative regulation of mitotic recombination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0045129 |
NAD-independent histone deacetylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(UniProtKB:P02309) |
Seeded From UniProt |
complete | ||
part_of |
GO:0034967 |
Set3 complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0017136 |
NAD-dependent histone deacetylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(UniProtKB:P02309) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016575 |
histone deacetylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_direct_input:(UniProtKB:P02309) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030466 |
chromatin silencing at silent mating-type cassette |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030466 |
chromatin silencing at silent mating-type cassette |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0070403 |
NAD+ binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000119154 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0046970 |
NAD-dependent histone deacetylase activity (H4-K16 specific) |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000872240 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0034967 |
Set3 complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000872240 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0031618 |
nuclear pericentric heterochromatin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000872240 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0017136 |
NAD-dependent histone deacetylase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0024291 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0017136 |
NAD-dependent histone deacetylase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0024291 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005730 |
nucleolus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000872240 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005724 |
nuclear telomeric heterochromatin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000872240 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005720 |
nuclear heterochromatin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000872240 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005677 |
chromatin silencing complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000872240 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000872240 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070933 |
histone H4 deacetylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046970 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0070403 |
NAD+ binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030435 |
sporulation resulting in formation of a cellular spore |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Li, M et al. (2010) Thiamine biosynthesis in Saccharomyces cerevisiae is regulated by the NAD+-dependent histone deacetylase Hst1. Mol. Cell. Biol. 30 3329-41 PubMed GONUTS page
- ↑ Chen, YF et al. (2016) Determinants of Sir2-Mediated, Silent Chromatin Cohesion. Mol. Cell. Biol. 36 2039-50 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Sutton, A et al. (2001) A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex. Mol. Cell. Biol. 21 3514-22 PubMed GONUTS page
- ↑ Lamming, DW et al. (2005) HST2 mediates SIR2-independent life-span extension by calorie restriction. Science 309 1861-4 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Pijnappel, WW et al. (2001) The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev. 15 2991-3004 PubMed GONUTS page
- ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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