User:Rousepie

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
updatedbyinstructor	ARATH:CAMT3	2014-04-01 22:02:25 CDT	GO:0042409 caffeoyl-CoA O-methyltransferase activity (F)	PMID:23416302	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 2 shows the shift in products made when comparing the wild-type to the mutant variants	challenge
updatedbyinstructor	HUMAN:MUC1	2014-04-06 15:43:35 CDT	GO:0033629 negative regulation of cell adhesion mediated by integrin (P)	PMID:7698991	ECO:0000314 direct assay evidence used in manual assertion	Figure 3 demonstrates percent adhesion to different extracellular matrix components. Figure 5 demonstrates the inhibition or induction of integrin-mediated adhesion by antibodies against integrin subunits or against episialin. These figures support the conclucsion that there needs to be a balance between adhesion and anti-adhesion forces in cells expressing episialin. This can be regulated by strengthening integrin-mediated adhesion or increasing level of episialin expression to inhibit cell adhesion.	challenge
updatedbyinstructor	HELPY:O25873	2014-04-06 16:09:38 CDT	GO:0052151 positive regulation by symbiont of host apoptotic process (P)	PMID:23228830	ECO:0000314 direct assay evidence used in manual assertion	Figure 3 shows that his-tagged HP1286 from H. pylori 26695 was also able to induce apoptosis of AGS cells four times more than untreated cells	challenge
updatedbyinstructor	HELPX:A7WPC5	2014-04-06 16:33:53 CDT	GO:0030255 protein secretion by the type IV secretion system (P)	PMID:23468628	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 4 shows a deletion within the cagY allele significantly affects the ability to translocate proteins	challenge
acceptable	HELPY:CAGT	2014-04-06 16:47:31 CDT	GO:0009306 protein secretion (P)	PMID:23075784	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 1 shows mutant variants in CagT which significantly have lowered translocation of CagA	challenge
unacceptable	HELPY:CAGT	2014-04-06 16:47:31 CDT	GO:0070258 beta-tubulin folding (P)	PMID:23075784	ECO:0000314 direct assay evidence used in manual assertion	Figure 2 shows cellular localization of CagT	challenge
acceptable	HELPY:CAGT	2014-04-06 16:47:31 CDT	GO:0019867 outer membrane (C)	PMID:23075784	ECO:0000314 direct assay evidence used in manual assertion	Figure 2 shows cellular localization of CagT	challenge
unacceptable	HELPY:CAGT	2014-04-06 16:51:57 CDT	GO:0005515 protein binding (F)	PMID:23075784	ECO:0000314 direct assay evidence used in manual assertion	Figure 3 shows interaction with CagA	challenge

acceptable:2
unacceptable:2
requires_changes:0
flagged:0

Annotations challenged by Rousepie

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history

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