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HUMAN:MUC1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MUC1 (synonyms: PUM) | |
| Protein Name(s) | Mucin-1
MUC-1 Breast carcinoma-associated antigen DF3 Cancer antigen 15-3 CA 15-3 Carcinoma-associated mucin Episialin H23AG Krebs von den Lungen-6 KL-6 PEMT Peanut-reactive urinary mucin PUM Polymorphic epithelial mucin PEM Tumor-associated epithelial membrane antigen EMA Tumor-associated mucin Mucin-1 subunit alpha MUC1-NT MUC1-alpha Mucin-1 subunit beta MUC1-beta MUC1-CT | |
| External Links | ||
| UniProt | P15941 | |
| EMBL | J05582 M32738 M32739 M34089 M34088 J05581 M61170 X52229 X52228 M35093 X80761 U60259 U60260 U60261 AF125525 AY466157 AY327582 AY327584 AY327586 AY327587 EF583653 EF670711 EF670712 FJ226040 FJ226047 AF348143 AY463543 AL713999 AL713999 AL713999 AL713999 CH471121 CH471121 CH471121 CH471121 BC120974 BC120975 Z17324 Z17325 M31823 S81781 S81736 M21868 | |
| CCDS | CCDS1098.1 CCDS30882.1 CCDS30883.1 CCDS41408.1 CCDS41409.1 CCDS55641.1 CCDS55642.1 | |
| PIR | A35175 | |
| RefSeq | NP_001018016.1 NP_001018017.1 NP_001037855.1 NP_001037856.1 NP_001037857.1 NP_001037858.1 NP_001191214.1 NP_001191215.1 NP_001191216.1 NP_001191217.1 NP_001191218.1 NP_001191219.1 NP_001191220.1 NP_001191221.1 NP_001191222.1 NP_001191223.1 NP_001191224.1 NP_001191225.1 NP_001191226.1 NP_002447.4 | |
| UniGene | Hs.89603 | |
| PDB | 1SM3 2ACM 2FO4 | |
| PDBsum | 1SM3 2ACM 2FO4 | |
| ProteinModelPortal | P15941 | |
| SMR | P15941 | |
| BioGrid | 110669 | |
| DIP | DIP-41890N | |
| IntAct | P15941 | |
| MINT | MINT-156679 | |
| MEROPS | S71.001 | |
| PhosphoSite | P15941 | |
| UniCarbKB | P15941 | |
| DMDM | 296439295 | |
| MaxQB | P15941 | |
| PaxDb | P15941 | |
| PRIDE | P15941 | |
| DNASU | 4582 | |
| Ensembl | ENST00000337604 ENST00000342482 ENST00000343256 ENST00000368389 ENST00000368390 ENST00000368392 ENST00000368393 ENST00000368396 ENST00000368398 ENST00000620103 | |
| GeneID | 4582 | |
| KEGG | hsa:4582 | |
| UCSC | uc001fia.3 uc001fib.3 uc001fid.3 uc001fie.3 uc001fig.3 uc001fij.3 uc001fik.3 uc001fin.3 uc009wpm.3 | |
| CTD | 4582 | |
| GeneCards | GC01M155158 | |
| GeneReviews | MUC1 | |
| HGNC | HGNC:7508 | |
| HPA | CAB000036 CAB001986 HPA004179 HPA007235 HPA008855 | |
| MIM | 113720 158340 174000 | |
| neXtProt | NX_P15941 | |
| Orphanet | 34149 | |
| PharmGKB | PA31309 | |
| eggNOG | NOG77744 | |
| GeneTree | ENSGT00710000106874 | |
| HOGENOM | HOG000290201 | |
| HOVERGEN | HBG003075 | |
| InParanoid | P15941 | |
| KO | K06568 | |
| PhylomeDB | P15941 | |
| Reactome | REACT_115606 REACT_115835 | |
| ChiTaRS | MUC1 | |
| EvolutionaryTrace | P15941 | |
| GeneWiki | MUC1 | |
| GenomeRNAi | 4582 | |
| NextBio | 13635564 | |
| PRO | PR:P15941 | |
| Proteomes | UP000005640 | |
| Bgee | P15941 | |
| ExpressionAtlas | P15941 | |
| Genevestigator | P15941 | |
| GO | GO:0016324 GO:0009986 GO:0005737 GO:0005615 GO:0070062 GO:0005796 GO:0005887 GO:0000790 GO:0031982 GO:0002039 GO:0000978 GO:0003712 GO:0044267 GO:0006977 GO:0006978 GO:1902166 GO:0010944 GO:0016266 GO:0090240 GO:0036003 GO:0043687 GO:0043618 | |
| Gene3D | 3.30.70.960 | |
| InterPro | IPR023217 IPR000082 | |
| PANTHER | PTHR10006:SF5 | |
| Pfam | PF01390 | |
| SMART | SM00200 | |
| SUPFAM | SSF82671 | |
| PROSITE | PS50024 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0033629 |
negative regulation of cell adhesion mediated by integrin |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031982 |
vesicle |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0002202) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001831) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001914) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902166 |
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090240 |
positive regulation of histone H4 acetylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043618 |
regulation of transcription from RNA polymerase II promoter in response to stress |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036003 |
positive regulation of transcription from RNA polymerase II promoter in response to stress |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010944 |
negative regulation of transcription by competitive promoter binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006978 |
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006977 |
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003712 |
transcription coregulator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0033629 |
negative regulation of cell adhesion mediated by integrin |
ECO:0000314 |
P |
Figure 3 demonstrates percent adhesion to different extracellular matrix components. Figure 5 demonstrates the inhibition or induction of integrin-mediated adhesion by antibodies against integrin subunits or against episialin. These figures support the conclucsion that there needs to be a balance between adhesion and anti-adhesion forces in cells expressing episialin. This can be regulated by strengthening integrin-mediated adhesion or increasing level of episialin expression to inhibit cell adhesion. |
complete | |||||
|
enables |
GO:0002039 |
p53 binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97231 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-6785807 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016266 |
O-glycan processing |
Reactome:R-HSA-913709 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-8858500 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005796 |
Golgi lumen |
Reactome:R-HSA-981814 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0002223 |
stimulatory C-type lectin receptor signaling pathway |
Reactome:R-HSA-5621481 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Wesseling, J et al. (1995) Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. J. Cell Biol. 129 255-65 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Kesimer, M et al. (2009) Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J. 23 1858-68 PubMed GONUTS page
- ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Pisitkun, T et al. (2004) Identification and proteomic profiling of exosomes in human urine. Proc. Natl. Acad. Sci. U.S.A. 101 13368-73 PubMed GONUTS page
- ↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
- ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 Wei, X et al. (2005) Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell 7 167-78 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Gendler, SJ et al. (1990) Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J. Biol. Chem. 265 15286-93 PubMed GONUTS page
c
d
e
n
- GO:0033629 ! negative regulation of cell adhesion mediated by integrin
- GO:0010944 ! negative regulation of transcription by competitive promoter binding
- GO:1902166 ! negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- GO:0000790 ! nuclear chromatin
- GO:0005634 ! nucleus
o
- GO:0016266 ! O-glycan processing
- GO:0036003 ! obsolete positive regulation of transcription from RNA polymerase II promoter in response to stress
- GO:0090240 ! obsolete positive regulation of histone H4 acetylation
- GO:0043618 ! obsolete regulation of transcription from RNA polymerase II promoter in response to stress
