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PMID:23228830
| Citation |
Li, J, Meng, FL, He, LH and Zhang, JZ (2012) Secreted protein HP1286 of Helicobacter pylori strain 26695 induces apoptosis of AGS cells. Biomed. Environ. Sci. 25:614-9 |
|---|---|
| Abstract |
Secreted proteins of Helicobacter pylori (H. pylori) interact with gastric epithelium cells and may contribute to cell damage. Considering the fact that HP0175 and hypothetical conserved protein HP1286 are included in the group and that HP0175 is a well-known apoptosis-induced factor, the present study aims to clarify whether HP1286 plays a role in bacterial pathogenicity or even functions as an apoptosis-induced factor in human stomach. |
| Links |
PubMed Online version:10.3967/0895-3988.2012.06.002 |
| Keywords |
Amino Acid Sequence; Apoptosis/drug effects; Bacterial Proteins/metabolism; Bacterial Proteins/pharmacology; Cell Line, Tumor; Cloning, Molecular; Escherichia coli/metabolism; Gene Expression Regulation, Bacterial; Genetic Variation; Helicobacter pylori/classification; Helicobacter pylori/genetics; Helicobacter pylori/metabolism; Humans; Molecular Sequence Data; Recombinant Proteins; Stomach Neoplasms |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0052151: positive regulation by symbiont of host apoptotic process |
ECO:0000314: |
P |
Figure 3 shows that his-tagged HP1286 from H. pylori 26695 was also able to induce apoptosis of AGS cells four times more than untreated cells |
complete | ||||
|
involved_in |
GO:0052151: positive regulation by symbiont of host apoptotic process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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