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Category:MichSt14A 46

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
unacceptableHELPY:CAGTRousepie, MichSt14A 462014-04-06 16:51:57 CDTGO:0005515 protein binding (F)PMID:23075784ECO:0000314 direct assay evidence used in manual assertion

Figure 3 shows interaction with CagA

challenge
acceptableHELPY:CAGTRousepie, MichSt14A 462014-04-06 16:47:31 CDTGO:0009306 protein secretion (P)PMID:23075784ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1 shows mutant variants in CagT which significantly have lowered translocation of CagA

challenge
unacceptableHELPY:CAGTRousepie, MichSt14A 462014-04-06 16:47:31 CDTGO:0070258 beta-tubulin folding (P)PMID:23075784ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows cellular localization of CagT

challenge
acceptableHELPY:CAGTRousepie, MichSt14A 462014-04-06 16:47:31 CDTGO:0019867 outer membrane (C)PMID:23075784ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows cellular localization of CagT

challenge
updatedbyinstructorHELPX:A7WPC5Rousepie, MichSt14A 462014-04-06 16:33:53 CDTGO:0030255 protein secretion by the type IV secretion system (P)PMID:23468628ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4 shows a deletion within the cagY allele significantly affects the ability to translocate proteins

challenge
updatedbyinstructorHELPY:O25873Rousepie, MichSt14A 462014-04-06 16:09:38 CDTGO:0052151 positive regulation by symbiont of host apoptotic process (P)PMID:23228830ECO:0000314 direct assay evidence used in manual assertion

Figure 3 shows that his-tagged HP1286 from H. pylori 26695 was also able to induce apoptosis of AGS cells four times

more than untreated cells

challenge
updatedbyinstructorHUMAN:MUC1Rousepie, MichSt14A 462014-04-06 15:43:35 CDTGO:0033629 negative regulation of cell adhesion mediated by integrin (P)PMID:7698991ECO:0000314 direct assay evidence used in manual assertion

Figure 3 demonstrates percent adhesion to different extracellular matrix components. Figure 5 demonstrates the inhibition or induction of integrin-mediated adhesion by antibodies against integrin subunits or against episialin. These figures support the conclucsion that there needs to be a balance between adhesion and anti-adhesion forces in cells expressing episialin. This can be regulated by strengthening integrin-mediated adhesion or increasing level of episialin expression to inhibit cell adhesion.

challenge
updatedbyinstructorARATH:CAMT3Rousepie, MichSt14A 462014-04-01 22:02:25 CDTGO:0042409 caffeoyl-CoA O-methyltransferase activity (F)PMID:23416302ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2 shows the shift in products made when comparing the wild-type to the mutant variants

challenge

What do the icons mean in the status column?

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