User:Lleopold

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
updatedbyinstructor	EBOZM:VP40	2013-09-14 22:23:23 CDT	GO:0046788 egress of virus within host cell (P)	PMID:23297401	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 8	challenge
requireschanges	EBOZM:VP40	2013-09-25 16:53:47 CDT	GO:0019076 viral release from host cell (P)	PMID:23297401	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 2B, 2C show that when certain key amino acids are mutated (L213A, L295A, V298A) they do not induce the same amount of surface pressure into the plasma membrane as compared to WT	challenge
updatedbyinstructor	EBOZM:VP40	2013-09-25 17:11:46 CDT	GO:0044385 integral to membrane of host cell (C)	PMID:23297401	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 3	challenge
updatedbyinstructor	HPV16:VE5	2013-10-13 10:09:56 CDT	GO:0020002 host cell plasma membrane (C)	PMID:19712955	ECO:0000314 direct assay evidence used in manual assertion	Figure 3 shows localization to the plasma membrane via immunofluorescence data	challenge
acceptable	HPV16:VE5	2013-10-13 10:32:31 CDT	GO:0019048 modulation by virus of host morphology or physiology (P)	PMID:20686024	ECO:0000314 direct assay evidence used in manual assertion	Figure 8 depicts the inhibition of endosome vesicle fusion by HP16 E5 protein	challenge
requireschanges	HPV16:VE5	2013-11-10 14:52:22 CST	GO:0072657 protein localization to membrane (P)	PMID:19712955	ECO:0000314 direct assay evidence used in manual assertion	Figure 3 shows protein localization to the plasma membrane via immunofluresence assay	challenge
requireschanges	EBOZM:VP40	2013-11-10 15:34:32 CST	GO:0020002 host cell plasma membrane (C)	PMID:23297401	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 8: Western blots of cells transfected with WT VP40 and several hydrophobic mutants demonstrate that C-terminal domain plasma membrane penetration is critical for viral egress.	challenge

acceptable:1
unacceptable:0
requires_changes:3
flagged:0

Annotations challenged by Lleopold

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
unacceptable	Smahoney2, Team Pitbull Hurricanes	SALT1:D0ZSD6	GO:0043190 - ATP-binding cassette (ABC) transporter complex (C)	PMID:24169575	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 1
unacceptable	Smahoney2, Team Pitbull Hurricanes	SALT1:D0ZSD6	GO:0043190 - ATP-binding cassette (ABC) transporter complex (C)	PMID:24169575	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 1
requireschanges	Mustful, Team Bcereus	?	GO:0003677 - DNA binding (Figure 1: Pathway of DNA-binding of STAT3 in the cell.)	PMID:24199193	IGI: Inferred from Genetic Interaction PMID:24199193 PMID:10523640	challenge	C: 1

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