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HPV16:VE5
Contents
| Species (Taxon ID) | Human papillomavirus type 16. (333760) | |
| Gene Name(s) | E5 | |
| Protein Name(s) | Probable protein E5 | |
| External Links | ||
| UniProt | P06927 | |
| EMBL | K02718 AF536179 | |
| PIR | A30016 | |
| RefSeq | NP_041330.2 | |
| IntAct | P06927 | |
| MINT | MINT-6732515 | |
| GeneID | 1489077 | |
| Proteomes | UP000009251 | |
| GO | GO:0044167 GO:0044177 GO:0016021 GO:0033668 GO:0039504 GO:0046776 | |
| InterPro | IPR004270 | |
| Pfam | PF03025 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0033668 |
negative regulation by symbiont of host apoptotic process |
ECO:0000315 |
P |
Figure 2 shows a TUNNEL in parts A and B where E2 has kept HFKs from going under apoptosis after being exposed to UV. L(16E5)SN-infected keratinocytes were exposed to 0 (A) and 400 (B) J of UV light, the cells were stained with DAPI. this happens by E5 enhancing EGFR activation. |
complete | |||||
| GO:0020002 |
host cell plasma membrane |
ECO:0000314 |
C |
Figure 3 shows localization to the plasma membrane via immunofluorescence data |
complete | |||||
| GO:0019048 |
modulation by virus of host morphology or physiology |
ECO:0000314 |
P |
Figure 8 depicts the inhibition of endosome vesicle fusion by HP16 E5 protein |
complete | |||||
| GO:0072657 |
protein localization to membrane |
ECO:0000314 |
P |
Figure 3 shows protein localization to the plasma membrane via immunofluresence assay |
complete | |||||
|
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072657 |
protein localization to membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019048 |
modulation by virus of host morphology or physiology |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033668 |
negative regulation by symbiont of host apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044177 |
host cell Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044165 |
host cell endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046776 |
suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030683 |
evasion or tolerance by virus of host immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039504 |
suppression by virus of host adaptive immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044167 |
host cell endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Zhang, B et al. (2002) E5 protein of human papillomavirus type 16 protects human foreskin keratinocytes from UV B-irradiation-induced apoptosis. J. Virol. 76 220-31 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Hu, L & Ceresa, BP (2009) Characterization of the plasma membrane localization and orientation of HPV16 E5 for cell-cell fusion. Virology 393 135-43 PubMed GONUTS page
- ↑ 3.0 3.1 Suprynowicz, FA et al. (2010) The human papillomavirus type 16 E5 oncoprotein inhibits epidermal growth factor trafficking independently of endosome acidification. J. Virol. 84 10619-29 PubMed GONUTS page
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