User:Kemmy

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
unacceptable	HUMAN:TERT	2014-02-25 01:48:29 CST	GO:0006915 apoptotic process (P)	PMID:23326372	ECO:0000314 direct assay evidence used in manual assertion	Nuclear localization of telomerase is correlated with higher amounts of DNA damage and apoptosis. (refer to Figure 2)	challenge
unacceptable	HUMAN:TERT	2014-02-26 14:47:14 CST	GO:0060218 hematopoietic stem cell differentiation (P)	PMID:23585473	ECO:0000315 mutant phenotype evidence used in manual assertion	Telomerase-mutant ipscs caused impaired hematopoietic differentiation in vitro. Ref to figure 6	challenge
unacceptable	HUMAN:CDC20	2014-02-26 15:56:12 CST	GO:0010467 gene expression (P)	PMID:24551295	ECO:0000314 direct assay evidence used in manual assertion	There is upregulation of CDC20 mRNA in cancerous tissues than in noncancerous tissues (ref. figure 1). This upregulation of CDC20 is also associated with aggressive progression and poor prognosis in gastric cancer. (ref. figure 3).	challenge
updatedbyinstructor	HUMAN:G45IP	2014-02-27 08:47:58 CST	GO:0071850 mitotic cell cycle arrest (P)	PMID:24520316	ECO:0000314 direct assay evidence used in manual assertion	CRIF1 overexpression increased the proportion of jurkat cells arrested in G0/G1 while endogenous depletion decreased cell cycle arrest. (refer to Figure 3)	challenge
updatedbyinstructor	CHLRE:F6LJD1	2014-02-27 10:01:17 CST	GO:1902326 positive regulation of chlorophyll biosynthetic process (P)	PMID:21527423	ECO:0000315 mutant phenotype evidence used in manual assertion	CIA6 mutant increased chlorophyll content per cell. (refer to Figure 8)	challenge
unacceptable	HUMAN:ZBT16	2014-03-02 15:14:07 CST	GO:0016604 nuclear body (C)	PMID:24359566	ECO:0000316 genetic interaction evidence used in manual assertion	Cellular localization of Znf179 was changed from cytoplasm to nucleus when PLZf was co-expressed. (Refer to Figure 4)	challenge

acceptable:0
unacceptable:4
requires_changes:0
flagged:0

Annotations challenged by Kemmy

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
acceptable	Jk, Team IREMAI	CAMDR:PGRP1	GO:0001818 - negative regulation of cytokine production (P)	PMID:23326499	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1

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