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HUMAN:G45IP

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) GADD45GIP1 (synonyms: MRPL59, PLINP1, PRG6)
Protein Name(s) Growth arrest and DNA damage-inducible proteins-interacting protein 1

39S ribosomal protein L59, mitochondrial MRP-L59 CKII beta-associating protein CR6-interacting factor 1 CRIF1 Papillomavirus L2-interacting nuclear protein 1 PLINP PLINP-1 p53-responsive gene 6 protein

External Links
UniProt Q8TAE8
EMBL AJ429498
AF479749
AF475095
BC004944
BC013039
BC013027
BC069200
AJ295986
AF147080
CCDS CCDS12290.1
RefSeq NP_443082.2
UniGene Hs.515164
PDB 3J7Y
PDBsum 3J7Y
ProteinModelPortal Q8TAE8
BioGrid 124721
IntAct Q8TAE8
MINT MINT-253595
STRING 9606.ENSP00000323065
PhosphoSite Q8TAE8
DMDM 74730346
MaxQB Q8TAE8
PaxDb Q8TAE8
PeptideAtlas Q8TAE8
PRIDE Q8TAE8
DNASU 90480
Ensembl ENST00000316939
GeneID 90480
KEGG hsa:90480
UCSC uc002mwb.4
CTD 90480
GeneCards GC19M013065
HGNC HGNC:29996
MIM 605162
neXtProt NX_Q8TAE8
PharmGKB PA134954784
eggNOG NOG285057
GeneTree ENSGT00390000013719
HOGENOM HOG000112686
HOVERGEN HBG068845
InParanoid Q8TAE8
OMA EQHIAEC
OrthoDB EOG7ZKSDX
PhylomeDB Q8TAE8
TreeFam TF323794
Reactome REACT_267602
REACT_267677
REACT_267680
GeneWiki GADD45GIP1
GenomeRNAi 90480
NextBio 76780
PRO PR:Q8TAE8
Proteomes UP000005640
Bgee Q8TAE8
CleanEx HS_GADD45GIP1
ExpressionAtlas Q8TAE8
Genevestigator Q8TAE8
GO GO:0005739
GO:0005634
GO:0007049
GO:0016032
InterPro IPR018472
Pfam PF10147

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0071850

mitotic cell cycle arrest

PMID:24520316[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0071850

mitotic cell cycle arrest

PMID:24520316[1]

ECO:0000314

P

CRIF1 overexpression increased the proportion of jurkat cells arrested in G0/G1 while endogenous depletion decreased cell cycle arrest. (refer to Figure 3)

complete
CACAO 9537

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018472

C

Seeded From UniProt

complete

involved_in

GO:0070126

mitochondrial translational termination

Reactome:R-HSA-5419276

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070125

mitochondrial translational elongation

Reactome:R-HSA-5389840

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

Reactome:R-HSA-5419281
Reactome:R-HSA-5419277
Reactome:R-HSA-5419273
Reactome:R-HSA-5419271
Reactome:R-HSA-5419264
Reactome:R-HSA-5419261

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005840

ribosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0689

C

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Ran, Q et al. (2014) CRIF1 interacting with CDK2 regulates bone marrow microenvironment-induced G0/G1 arrest of leukemia cells. PLoS ONE 9 e85328 PubMed GONUTS page