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PMID:24520316
| Citation |
Ran, Q, Hao, P, Xiao, Y, Xiang, L, Ye, X, Deng, X, Zhao, J and Li, Z (2014) CRIF1 Interacting with CDK2 Regulates Bone Marrow Microenvironment-Induced G0/G1 Arrest of Leukemia Cells. PLoS ONE 9:e85328 |
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| Abstract |
To assess the level of CR6-interacting factor 1 (CRIF1), a cell cycle negative regulator, in patients with leukemia and investigate the role of CRIF1 in regulating leukemia cell cycle. |
| Links |
PubMed PMC3919709 Online version:10.1371/journal.pone.0085328 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0071850: mitotic cell cycle arrest |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0071850: mitotic cell cycle arrest |
ECO:0000314: |
P |
CRIF1 overexpression increased the proportion of jurkat cells arrested in G0/G1 while endogenous depletion decreased cell cycle arrest. (refer to Figure 3) |
complete | ||||
See also
References
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