GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:CDC20

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CDC20
Protein Name(s) Cell division cycle protein 20 homolog

p55CDC

External Links
UniProt Q12834
EMBL U05340
AF099644
AK312780
BT007388
DQ473545
AL139289
CH471059
CH471059
BC000624
BC001088
BC006272
BC009425
BC009426
BC010044
BC012803
BC012827
BC013303
BC015998
BC024257
BC031294
BC110321
CCDS CCDS484.1
PIR A56021
RefSeq NP_001246.2
UniGene Hs.524947
PDB 4GGA
4GGC
4GGD
4N14
PDBsum 4GGA
4GGC
4GGD
4N14
ProteinModelPortal Q12834
SMR Q12834
BioGrid 107427
DIP DIP-29655N
IntAct Q12834
MINT MINT-2211271
STRING 9606.ENSP00000308450
PhosphoSite Q12834
DMDM 37537762
MaxQB Q12834
PaxDb Q12834
PRIDE Q12834
DNASU 991
Ensembl ENST00000310955
ENST00000372462
GeneID 991
KEGG hsa:991
UCSC uc001cix.3
CTD 991
GeneCards GC01P043824
H-InvDB HIX0034879
HGNC HGNC:1723
HPA CAB004525
HPA045842
HPA055288
MIM 603618
neXtProt NX_Q12834
PharmGKB PA26257
eggNOG COG2319
GeneTree ENSGT00760000119352
HOGENOM HOG000195514
HOVERGEN HBG001024
InParanoid Q12834
KO K03363
OMA VSSLCWN
OrthoDB EOG76X602
PhylomeDB Q12834
TreeFam TF101065
Reactome REACT_1041
REACT_1072
REACT_150425
REACT_150471
REACT_6761
REACT_6781
REACT_682
REACT_6820
REACT_6821
REACT_6837
REACT_6867
REACT_6871
REACT_6875
REACT_75842
SignaLink Q12834
UniPathway UPA00143
ChiTaRS CDC20
GeneWiki CDC20
GenomeRNAi 991
NextBio 4160
PMAP-CutDB Q12834
PRO PR:Q12834
Proteomes UP000005640
Bgee Q12834
CleanEx HS_CDC20
Genevestigator Q12834
GO GO:0005813
GO:0005737
GO:0005829
GO:0005654
GO:0005634
GO:0048471
GO:0043234
GO:0005819
GO:0000922
GO:0019899
GO:0008022
GO:0051488
GO:0031145
GO:0007049
GO:0000278
GO:0007067
GO:0007094
GO:0051436
GO:0008284
GO:0090129
GO:0031915
GO:0051437
GO:0016567
GO:0050773
GO:0040020
GO:0051439
Gene3D 2.130.10.10
InterPro IPR015943
IPR001680
IPR019775
IPR017986
Pfam PF00400
SMART SM00320
SUPFAM SSF50978
PROSITE PS00678
PS50082
PS50294

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0090129

positive regulation of synapse maturation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9JJ66

P

Seeded From UniProt

complete

involved_in

GO:1904668

positive regulation of ubiquitin protein ligase activity

PMID:11459826[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031915

positive regulation of synaptic plasticity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9JJ66

P

Seeded From UniProt

complete

involved_in

GO:0031145

anaphase-promoting complex-dependent catabolic process

PMID:17443180[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

PMID:17443180[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9H0E7

F

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

PMID:10700282[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13257

F

Seeded From UniProt

complete

colocalizes_with

GO:0005680

anaphase-promoting complex

PMID:11459825[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050773

regulation of dendrite development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62623
ensembl:ENSRNOP00000037772

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62623
ensembl:ENSRNOP00000037772

C

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62623
ensembl:ENSRNOP00000037772

F

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62623
ensembl:ENSRNOP00000037772

C

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62623
ensembl:ENSRNOP00000037772

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62623
ensembl:ENSRNOP00000037772

C

Seeded From UniProt

complete

involved_in

GO:0090307

mitotic spindle assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ66
ensembl:ENSMUSP00000006565

P

Seeded From UniProt

complete

involved_in

GO:0090129

positive regulation of synapse maturation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ66
ensembl:ENSMUSP00000006565

P

Seeded From UniProt

complete

involved_in

GO:0040020

regulation of meiotic nuclear division

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ66
ensembl:ENSMUSP00000006565

P

Seeded From UniProt

complete

involved_in

GO:0031915

positive regulation of synaptic plasticity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ66
ensembl:ENSMUSP00000006565

P

Seeded From UniProt

complete

involved_in

GO:0007064

mitotic sister chromatid cohesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ66
ensembl:ENSMUSP00000006565

P

Seeded From UniProt

complete

enables

GO:0010997

anaphase-promoting complex binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033010
InterPro:IPR033187

F

Seeded From UniProt

complete

involved_in

GO:0031145

anaphase-promoting complex-dependent catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033187

P

Seeded From UniProt

complete

enables

GO:0097027

ubiquitin-protein transferase activator activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033010

F

Seeded From UniProt

complete

involved_in

GO:1904668

positive regulation of ubiquitin protein ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033010
InterPro:IPR033187

P

Seeded From UniProt

complete

part_of

GO:0005819

spindle

PMID:7513050[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1901990

regulation of mitotic cell cycle phase transition

Reactome:R-HSA-174238
Reactome:R-HSA-174113

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0031145

anaphase-promoting complex-dependent catabolic process

Reactome:R-HSA-174184
Reactome:R-HSA-174178
Reactome:R-HSA-174154
Reactome:R-HSA-174143
Reactome:R-HSA-174048

ECO:0000304

author statement supported by traceable reference used in manual assertion





P

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

Reactome:R-HSA-5688426

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007094

mitotic spindle assembly checkpoint

Reactome:R-HSA-69618

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

Reactome:R-HSA-174227
Reactome:R-HSA-174195
Reactome:R-HSA-174144
Reactome:R-HSA-174104

ECO:0000304

author statement supported by traceable reference used in manual assertion




P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5666169
Reactome:R-HSA-5666160
Reactome:R-HSA-5666129
Reactome:R-HSA-375302
Reactome:R-HSA-2484822
Reactome:R-HSA-2468287
Reactome:R-HSA-2467811
Reactome:R-HSA-2467809
Reactome:R-HSA-179421
Reactome:R-HSA-179417
Reactome:R-HSA-179410
Reactome:R-HSA-174255
Reactome:R-HSA-174238
Reactome:R-HSA-174227
Reactome:R-HSA-174224
Reactome:R-HSA-174209
Reactome:R-HSA-174203
Reactome:R-HSA-174202
Reactome:R-HSA-174195
Reactome:R-HSA-174171
Reactome:R-HSA-174159
Reactome:R-HSA-174157
Reactome:R-HSA-174144
Reactome:R-HSA-174121
Reactome:R-HSA-174120
Reactome:R-HSA-174105
Reactome:R-HSA-174104
Reactome:R-HSA-174088
Reactome:R-HSA-1638821
Reactome:R-HSA-1638803
Reactome:R-HSA-141439
Reactome:R-HSA-141437
Reactome:R-HSA-141431
Reactome:R-HSA-141429
Reactome:R-HSA-141423
Reactome:R-HSA-141422
Reactome:R-HSA-141409

ECO:0000304

author statement supported by traceable reference used in manual assertion





































C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-5696958
Reactome:R-HSA-174235
Reactome:R-HSA-174174
Reactome:R-HSA-174122

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0448

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

GO:0010467

gene expression

PMID:24551295[6]

ECO:0000314

P

There is upregulation of CDC20 mRNA in cancerous tissues than in noncancerous tissues (ref. figure 1). This upregulation of CDC20 is also associated with aggressive progression and poor prognosis in gastric cancer. (ref. figure 3).

complete
CACAO 9532

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Chen, J & Fang, G (2001) MAD2B is an inhibitor of the anaphase-promoting complex. Genes Dev. 15 1765-70 PubMed GONUTS page
  2. ↑ 2.0 2.1 Stegmeier, F et al. (2007) Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature 446 876-81 PubMed GONUTS page
  3. ↑ Luo, X et al. (2000) Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. Nat. Struct. Biol. 7 224-9 PubMed GONUTS page
  4. ↑ Pfleger, CM et al. (2001) Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1. Genes Dev. 15 1759-64 PubMed GONUTS page
  5. ↑ Weinstein, J et al. (1994) A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4. Mol. Cell. Biol. 14 3350-63 PubMed GONUTS page
  6. ↑ Ding, ZY et al. (2014) Expression characteristics of CDC20 in gastric cancer and its correlation with poor prognosis. Int J Clin Exp Pathol 7 722-7 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:CDC20&oldid=5954667"