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User:Kelly.huth4500

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My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
updatedbyinstructorHUMAN:CRTC32012-10-07 13:54:30 CDTGO:0042116 macrophage activation (P)PMID:23033494ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 6D shows that CRTC3 is required for the induction of markers of regulatory macrophages.

challenge
unacceptableHUMAN:SNAI12012-10-06 13:10:19 CDTGO:0010629 negative regulation of gene expression (P)PMID:23029563ECO:0000314 direct assay evidence used in manual assertion

Figure 3A shows that "the amount of CDH1 mRNA was significantly lower in SNAI1 positive adenomas compared to SNAI1 negative ones."

challenge
acceptableMOUSE:BCR2012-11-17 17:36:20 CSTGO:0060313 negative regulation of blood vessel remodeling (P)PMID:23152932ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2A shows that the walls of the pulmonary arteries of the

bcr-/- mice are remarkably thicker than those of the wt mice after hypoxia, suggesting that bcr is one component needed for the prevention of artery remodeling

challenge
acceptableMOUSE:ABR2012-11-17 17:40:04 CSTGO:0060313 negative regulation of blood vessel remodeling (P)PMID:23152932ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2A shows that the walls of the pulmonary arteries of the abr-/- mice are remarkably thicker than those of the wt mice after hypoxia, suggesting that abr is one component needed for the prevention of artery remodeling

challenge
acceptableMOUSE:ABR2012-11-17 17:40:04 CSTGO:0043114 regulation of vascular permeability (P)PMID:23152932ECO:0000315 mutant phenotype evidence used in manual assertion

"Figure 3C shows that chronic hypoxia promoted loss of endothelial barrier function and, moreover, mice lacking Abr...were clearly more severely affected." This suggests that abr is a component needed for the prevention of vascular leakage under hypoxic conditions.

challenge
acceptableMOUSE:BCR2012-11-17 18:00:14 CSTGO:0043114 regulation of vascular permeability (P)PMID:23152932ECO:0000315 mutant phenotype evidence used in manual assertion

"Figure 3C shows that chronic hypoxia promoted loss of endothelial barrier function and, moreover, mice lacking Bcr...were clearly more severely affected." This suggests that bcr is a component needed for the prevention of vascular leakage under hypoxic conditions.

challenge
updatedbyinstructorMOUSE:ABR2012-11-17 18:36:02 CSTGO:0002692 negative regulation of cellular extravasation (P)PMID:23152932ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3A shows that "pulmonary extravasation of leukocytes under hypoxia was significantly increased in the mice lacking Abr...function as compared to wt mice," suggesting that abr prevents leukocytes from pulmonary extravasation.

challenge
updatedbyinstructorMOUSE:BCR2012-11-17 18:39:44 CSTGO:0002692 negative regulation of cellular extravasation (P)PMID:23152932ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3A shows that "pulmonary extravasation of leukocytes under hypoxia was significantly increased in the mice lacking... Bcr function as compared to wt mice," suggesting that bcr prevents leukocytes from pulmonary extravasation.

challenge

acceptable:4
unacceptable:1
requires_changes:0
flagged:0

Annotations challenged by Kelly.huth4500

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history

0 annotations fixed by Kelly.huth4500