User:Kelly.huth4500

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
updatedbyinstructor	HUMAN:CRTC3	2012-10-07 13:54:30 CDT	GO:0042116 macrophage activation (P)	PMID:23033494	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 6D shows that CRTC3 is required for the induction of markers of regulatory macrophages.	challenge
unacceptable	HUMAN:SNAI1	2012-10-06 13:10:19 CDT	GO:0010629 negative regulation of gene expression (P)	PMID:23029563	ECO:0000314 direct assay evidence used in manual assertion	Figure 3A shows that "the amount of CDH1 mRNA was significantly lower in SNAI1 positive adenomas compared to SNAI1 negative ones."	challenge
acceptable	MOUSE:BCR	2012-11-17 17:36:20 CST	GO:0060313 negative regulation of blood vessel remodeling (P)	PMID:23152932	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 2A shows that the walls of the pulmonary arteries of the bcr-/- mice are remarkably thicker than those of the wt mice after hypoxia, suggesting that bcr is one component needed for the prevention of artery remodeling	challenge
acceptable	MOUSE:ABR	2012-11-17 17:40:04 CST	GO:0060313 negative regulation of blood vessel remodeling (P)	PMID:23152932	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 2A shows that the walls of the pulmonary arteries of the abr-/- mice are remarkably thicker than those of the wt mice after hypoxia, suggesting that abr is one component needed for the prevention of artery remodeling	challenge
acceptable	MOUSE:ABR	2012-11-17 17:40:04 CST	GO:0043114 regulation of vascular permeability (P)	PMID:23152932	ECO:0000315 mutant phenotype evidence used in manual assertion	"Figure 3C shows that chronic hypoxia promoted loss of endothelial barrier function and, moreover, mice lacking Abr...were clearly more severely affected." This suggests that abr is a component needed for the prevention of vascular leakage under hypoxic conditions.	challenge
acceptable	MOUSE:BCR	2012-11-17 18:00:14 CST	GO:0043114 regulation of vascular permeability (P)	PMID:23152932	ECO:0000315 mutant phenotype evidence used in manual assertion	"Figure 3C shows that chronic hypoxia promoted loss of endothelial barrier function and, moreover, mice lacking Bcr...were clearly more severely affected." This suggests that bcr is a component needed for the prevention of vascular leakage under hypoxic conditions.	challenge
updatedbyinstructor	MOUSE:ABR	2012-11-17 18:36:02 CST	GO:0002692 negative regulation of cellular extravasation (P)	PMID:23152932	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 3A shows that "pulmonary extravasation of leukocytes under hypoxia was significantly increased in the mice lacking Abr...function as compared to wt mice," suggesting that abr prevents leukocytes from pulmonary extravasation.	challenge
updatedbyinstructor	MOUSE:BCR	2012-11-17 18:39:44 CST	GO:0002692 negative regulation of cellular extravasation (P)	PMID:23152932	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 3A shows that "pulmonary extravasation of leukocytes under hypoxia was significantly increased in the mice lacking... Bcr function as compared to wt mice," suggesting that bcr prevents leukocytes from pulmonary extravasation.	challenge

acceptable:4
unacceptable:1
requires_changes:0
flagged:0

Annotations challenged by Kelly.huth4500

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history

0 annotations fixed by Kelly.huth4500