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HUMAN:CRTC3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CRTC3 (synonyms: TORC3)
Protein Name(s) CREB-regulated transcription coactivator 3

Transducer of regulated cAMP response element-binding protein 3 TORC-3 Transducer of CREB protein 3

External Links
UniProt Q6UUV7
EMBL AY360173
AK090443
AC021422
AC103739
AK025521
BC074730
BC074731
CCDS CCDS32331.1
CCDS45348.1
RefSeq NP_001036039.1
NP_073606.3
UniGene Hs.567572
ProteinModelPortal Q6UUV7
BioGrid 122294
DIP DIP-59211N
IntAct Q6UUV7
STRING 9606.ENSP00000268184
PhosphoSite Q6UUV7
DMDM 167009130
MaxQB Q6UUV7
PaxDb Q6UUV7
PRIDE Q6UUV7
Ensembl ENST00000268184
ENST00000420329
GeneID 64784
KEGG hsa:64784
UCSC uc002bpo.4
uc002bpp.4
CTD 64784
GeneCards GC15P091073
HGNC HGNC:26148
HPA HPA043735
MIM 608986
neXtProt NX_Q6UUV7
PharmGKB PA142672074
eggNOG NOG74259
GeneTree ENSGT00390000010652
HOGENOM HOG000111980
HOVERGEN HBG058314
InParanoid Q6UUV7
KO K16334
OMA YMGFCDG
OrthoDB EOG7MKW5P
PhylomeDB Q6UUV7
TreeFam TF321571
ChiTaRS CRTC3
GeneWiki CRTC3
GenomeRNAi 64784
NextBio 66826
PRO PR:Q6UUV7
Proteomes UP000005640
Bgee Q6UUV7
CleanEx HS_CRTC3
ExpressionAtlas Q6UUV7
Genevestigator Q6UUV7
GO GO:0005737
GO:0005634
GO:0008140
GO:0097009
GO:0043951
GO:0050995
GO:0032793
GO:0045944
GO:0051289
GO:0006351
GO:0016032
InterPro IPR024786
IPR024785
IPR024784
IPR024783
PANTHER PTHR13589
Pfam PF12886
PF12885
PF12884

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0042116

macrophage activation

PMID:23033494[1]

ECO:0000315

P

Figure 6D shows that CRTC3 is required for the induction of markers of regulatory macrophages.

complete
CACAO 5241

involved_in

GO:0042116

macrophage activation

PMID:23033494[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1917711
MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040
UniProtKB:Q6UUV9

P

Seeded From UniProt

complete

involved_in

GO:0032793

positive regulation of CREB transcription factor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040

P

Seeded From UniProt

complete

enables

GO:0008140

cAMP response element binding protein binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001006040
UniProtKB:Q6UUV9
WB:WBGene00021237

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1917711
MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040
RGD:1308903
RGD:1589158
WB:WBGene00021237

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0036746
MGI:MGI:1917711
MGI:MGI:1921593
MGI:MGI:2142523
PANTHER:PTN001006040
RGD:1308903
RGD:1589158
UniProtKB:Q6UUV9
WB:WBGene00021237

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0097009

energy homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X84
ensembl:ENSMUSP00000113540

P

Seeded From UniProt

complete

involved_in

GO:0050995

negative regulation of lipid catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X84
ensembl:ENSMUSP00000113540

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X84
ensembl:ENSMUSP00000113540

P

Seeded From UniProt

complete

involved_in

GO:0043951

negative regulation of cAMP-mediated signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X84
ensembl:ENSMUSP00000113540

P

Seeded From UniProt

complete

involved_in

GO:0032793

positive regulation of CREB transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X84
ensembl:ENSMUSP00000113540

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X84
ensembl:ENSMUSP00000113540

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q91X84
ensembl:ENSMUSP00000113540

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024786

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024786

C

Seeded From UniProt

complete

enables

GO:0008140

cAMP response element binding protein binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024783

F

Seeded From UniProt

complete

involved_in

GO:0032793

positive regulation of CREB transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024786

P

Seeded From UniProt

complete

involved_in

GO:0051289

protein homotetramerization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024783

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Clark, K et al. (2012) Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc. Natl. Acad. Sci. U.S.A. 109 16986-91 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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