HUMAN:SNAI1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SNAI1 (synonyms: SNAH)
Protein Name(s)	Zinc finger protein SNAI1 Protein snail homolog 1 Protein sna
External Links
UniProt	O95863
EMBL	AF125377 AJ245657 AJ245658 AJ245659 AF155233 AF177731 AK313228 AL121712 BC012910 AF131208
CCDS	CCDS13423.1
RefSeq	NP_005976.2
UniGene	Hs.48029
PDB	2Y48 3W5K
PDBsum	2Y48 3W5K
ProteinModelPortal	O95863
SMR	O95863
BioGrid	112499
DIP	DIP-50870N
IntAct	O95863
MINT	MINT-7384880
STRING	9606.ENSP00000244050
PhosphoSite	O95863
PaxDb	O95863
PRIDE	O95863
DNASU	6615
Ensembl	ENST00000244050
GeneID	6615
KEGG	hsa:6615
UCSC	uc002xuz.3
CTD	6615
GeneCards	GC20P048599
HGNC	HGNC:11128
HPA	CAB005883
MIM	604238
neXtProt	NX_O95863
PharmGKB	PA35977
eggNOG	COG5048
GeneTree	ENSGT00390000011027
HOGENOM	HOG000261665
HOVERGEN	HBG007477
InParanoid	O95863
KO	K05707
OMA	CNKEYLS
OrthoDB	EOG7P2XSG
PhylomeDB	O95863
TreeFam	TF315515
EvolutionaryTrace	O95863
GeneWiki	SNAI1
GenomeRNAi	6615
NextBio	25757
PRO	PR:O95863
Proteomes	UP000005640
Bgee	O95863
CleanEx	HS_SNAI1
Genevestigator	O95863
GO	GO:0005737 GO:0005634 GO:0019900 GO:0046872 GO:0001078 GO:0000977 GO:0060536 GO:0016477 GO:0001837 GO:0031069 GO:0060972 GO:0001707 GO:0060806 GO:0043518 GO:1902230 GO:0000122 GO:0010957 GO:0061314 GO:0001649 GO:0060021 GO:0030335 GO:0010718 GO:0045893 GO:2000810 GO:0060707
Gene3D	3.30.160.60
InterPro	IPR029795 IPR007087 IPR015880 IPR013087
PANTHER	PTHR11389:SF430
Pfam	PF00096
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010629	negative regulation of gene expression	PMID:23029563^[1]	ECO:0000314			P		Figure 3A shows that "the amount of CDH1 mRNA was significantly lower in SNAI1 positive adenomas compared to SNAI1 negative ones."	complete CACAO 5254
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:11912130^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(ENSEMBL:ENSG00000039068) occurs_at:(SO:0001158)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:E9Q3T6 UniProtKB:O14978 UniProtKB:O95125 UniProtKB:O95863 UniProtKB:P10071 UniProtKB:P10754 UniProtKB:P17028 UniProtKB:P28698 UniProtKB:P36508 UniProtKB:P41183 UniProtKB:P47806 UniProtKB:P52738 UniProtKB:Q02085 UniProtKB:Q05516 UniProtKB:Q08376 UniProtKB:Q0VDQ9 UniProtKB:Q16600 UniProtKB:Q61967 UniProtKB:Q6DJT9 UniProtKB:Q6NUN9 UniProtKB:Q86UQ0 UniProtKB:Q8CIV7 UniProtKB:Q8K0L9 UniProtKB:Q8K3J5 UniProtKB:Q8NI51 UniProtKB:Q91ZD1 UniProtKB:Q96RE9 UniProtKB:Q99684 UniProtKB:Q9BU19 UniProtKB:Q9ESP5 UniProtKB:Q9GZX5 UniProtKB:Q9H116 UniProtKB:Q9NQX1 UniProtKB:Q9NZL3 UniProtKB:Q9QY31 UniProtKB:Q9UM63 UniProtKB:Q9UPG8 UniProtKB:Q9UQR1 UniProtKB:Q9WTJ2 UniProtKB:Q9Y2X9 UniProtKB:Q9Y473 UniProtKB:Q9Y5A6	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070828	heterochromatin organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02085	P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02085	P		Seeded From UniProt	complete
involved_in	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02085	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:11912130^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0001227) part_of:(GO:0000122) has_input:(ENSEMBL:ENSG00000039068)	Seeded From UniProt	complete
part_of	GO:0005721	pericentric heterochromatin	PMID:24239292^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25893292^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23288509^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:23288509^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24209753^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24209753^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000810	regulation of bicellular tight junction assembly	PMID:15314165^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	PMID:15314165^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061314	Notch signaling involved in heart development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02085	P		Seeded From UniProt	complete
involved_in	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	PMID:15314165^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:15314165^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010957	negative regulation of vitamin D biosynthetic process	PMID:19502595^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:11912130^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(ENSEMBL:ENSG00000039068) occurs_at:(SO:0001158)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15314165^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:11912130^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000039068)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20018240^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:20018240^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	PMID:15448698^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:20018240^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19955572^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15448698^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02085	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19955572^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15448698^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02085	C		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:16096638^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02085	P		Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02085	P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	PMID:20128911^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02085	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070828	heterochromatin organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
involved_in	GO:0061314	Notch signaling involved in heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
involved_in	GO:0060972	left/right pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
involved_in	GO:0060806	negative regulation of cell differentiation involved in embryonic placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
involved_in	GO:0060707	trophoblast giant cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
involved_in	GO:0060536	cartilage morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
involved_in	GO:0060021	roof of mouth development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	F		Seeded From UniProt	complete
involved_in	GO:0031069	hair follicle morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
involved_in	GO:0007498	mesoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	C		Seeded From UniProt	complete
part_of	GO:0005721	pericentric heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	C		Seeded From UniProt	complete
involved_in	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02085 ensembl:ENSMUSP00000050581	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	PMID:20951801^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	PMID:20951801^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0003180) occurs_in:(CL:2000008)	Seeded From UniProt	complete
involved_in	GO:0061314	Notch signaling involved in heart development	PMID:20951801^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0003198) occurs_in:(CL:2000008) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:17072303^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8944026	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kroepil, F et al. (2012) Down-regulation of CDH1 is associated with expression of SNAI1 in colorectal adenomas. PLoS ONE 7 e46665 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Hajra, KM et al. (2002) The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 62 1613-8 PubMed GONUTS page
↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Millanes-Romero, A et al. (2013) Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition. Mol. Cell 52 746-57 PubMed GONUTS page
↑ Hwangbo, C et al. (2016) Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Oncogene 35 389-401 PubMed GONUTS page
↑ ^6.0 ^6.1 Yuan, H et al. (2013) ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian cancer cells. Cancer Res. 73 1581-90 PubMed GONUTS page
↑ ^7.0 ^7.1 Mingot, JM et al. (2013) eEF1A mediates the nuclear export of SNAG-containing proteins via the Exportin5-aminoacyl-tRNA complex. Cell Rep 5 727-37 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Kajita, M et al. (2004) Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Mol. Cell. Biol. 24 7559-66 PubMed GONUTS page
↑ Larriba, MJ et al. (2009) Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer. Carcinogenesis 30 1459-68 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Medici, D & Nawshad, A (2010) Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-kappaB and LEF-1. Matrix Biol. 29 161-5 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Zhou, BP et al. (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 6 931-40 PubMed GONUTS page
↑ ^12.0 ^12.1 Viñas-Castells, R et al. (2010) The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. J. Biol. Chem. 285 3794-805 PubMed GONUTS page
↑ Peinado, H et al. (2005) A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO J. 24 3446-58 PubMed GONUTS page
↑ Lambertini, E et al. (2010) SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts. BMC Mol. Biol. 11 13 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Riley, MF et al. (2011) NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT. Biochim. Biophys. Acta 1812 121-9 PubMed GONUTS page
↑ Yook, JI et al. (2006) A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat. Cell Biol. 8 1398-406 PubMed GONUTS page

[PMID:23029563-1] Kroepil, F et al. (2012) Down-regulation of CDH1 is associated with expression of SNAI1 in colorectal adenomas. PLoS ONE 7 e46665 PubMed GONUTS page

[PMID:11912130-2] 2.0 ^2.1 ^2.2 ^2.3 Hajra, KM et al. (2002) The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 62 1613-8 PubMed GONUTS page

[PMID:19274049-3] Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:24239292-4] Millanes-Romero, A et al. (2013) Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition. Mol. Cell 52 746-57 PubMed GONUTS page

[PMID:25893292-5] Hwangbo, C et al. (2016) Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Oncogene 35 389-401 PubMed GONUTS page

[PMID:23288509-6] 6.0 ^6.1 Yuan, H et al. (2013) ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian cancer cells. Cancer Res. 73 1581-90 PubMed GONUTS page

[PMID:24209753-7] 7.0 ^7.1 Mingot, JM et al. (2013) eEF1A mediates the nuclear export of SNAG-containing proteins via the Exportin5-aminoacyl-tRNA complex. Cell Rep 5 727-37 PubMed GONUTS page

[PMID:15314165-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Kajita, M et al. (2004) Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Mol. Cell. Biol. 24 7559-66 PubMed GONUTS page

[PMID:19502595-9] Larriba, MJ et al. (2009) Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer. Carcinogenesis 30 1459-68 PubMed GONUTS page

[PMID:20018240-10] 10.0 ^10.1 ^10.2 Medici, D & Nawshad, A (2010) Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-kappaB and LEF-1. Matrix Biol. 29 161-5 PubMed GONUTS page

[PMID:15448698-11] 11.0 ^11.1 ^11.2 Zhou, BP et al. (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 6 931-40 PubMed GONUTS page

[PMID:19955572-12] 12.0 ^12.1 Viñas-Castells, R et al. (2010) The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. J. Biol. Chem. 285 3794-805 PubMed GONUTS page

[PMID:16096638-13] Peinado, H et al. (2005) A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO J. 24 3446-58 PubMed GONUTS page

[PMID:20128911-14] Lambertini, E et al. (2010) SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts. BMC Mol. Biol. 11 13 PubMed GONUTS page

[PMID:20951801-15] 15.0 ^15.1 ^15.2 Riley, MF et al. (2011) NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT. Biochim. Biophys. Acta 1812 121-9 PubMed GONUTS page

[PMID:17072303-16] Yook, JI et al. (2006) A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat. Cell Biol. 8 1398-406 PubMed GONUTS page

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HUMAN:SNAI1

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