User:Ha856981

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
updatedbyinstructor	BORBG:OSPA7	2012-03-26 15:00:12 CDT	GO:0007155 cell adhesion (P)	PMID:22355605	ECO:0000314 direct assay evidence used in manual assertion	figure 2 demonstrated the adhesion of OspA proteins to CD40 molecules in brain-microvascular endothelia cells, showing that Correlial adhesion to the endothelial cells	challenge
requireschanges	BACAN:LEF	2012-03-29 15:39:43 CDT	GO:0006508 proteolysis (P)	PMID:22438953	ECO:0000314 direct assay evidence used in manual assertion	figure 5 demonstrated that "the specific proteolytic activity of lethal factor of the MKKs is required for the anti-proliferate and pro-apoptotic effects of lethal toxin on the intestinal epithelium" ; the data also established the proteolysis activity of lethal factor of Anthrax lethal toxin	challenge
acceptable	BACAN:LEF	2012-03-29 15:47:24 CDT	GO:0009405 pathogenesis (P)	PMID:22438953	ECO:0000270 expression pattern evidence used in manual assertion	figure 2 - "in time course study, lethal toxin-induced pathological changes became evident in the intestine 48 hours post lethal toxin exposure. these changes included the onset of villous damage and minor hemorrhage. by 72 hours post lethal toxin exposure, focal areas showed marked destruction of the normal villous structures, accompanied by ares ulceration"	challenge
requireschanges	BACAN:Q81JD7	2012-03-29 16:41:13 CDT	GO:0006958 complement activation, classical pathway (P)	PMID:22442442	ECO:0000314 direct assay evidence used in manual assertion	figure 5 demonstrated that the presence of BclA protein significantly enhance the C3 deposition on the spore surface; C3 is a critical components in classical complement pathway	challenge
acceptable	BACAN:Q81JD7	2012-03-29 16:40:57 CDT	GO:0050764 regulation of phagocytosis (P)	PMID:22442442	ECO:0000314 direct assay evidence used in manual assertion	Figure 7 "suggested BclA is required for complement-mediated phagocytosis of spores"	challenge
requireschanges	CLOTE:TETX	2012-03-31 10:08:17 CDT	GO:0033619 membrane protein proteolysis (P)	PMID:22392932	ECO:0000314 direct assay evidence used in manual assertion	"Figure 8 demonstrated TeNT cleavage of VAMP2 (Vesicle-associated membrane protein 2) in rat cortical neurons."	challenge
acceptable	CLOBO:BXC1	2012-03-31 10:20:27 CDT	GO:0045955 negative regulation of calcium ion-dependent exocytosis (P)	PMID:8611567	ECO:0000314 direct assay evidence used in manual assertion	figure 1 demonstrated the induced inhibition of catecholamine release detected by immunoassay	challenge
acceptable	CLOBO:BXC1	2012-03-31 10:25:21 CDT	GO:0033619 membrane protein proteolysis (P)	PMID:8611567	ECO:0000314 direct assay evidence used in manual assertion	figure 1 demonstrated that when botulinum toxin BoNT binds to receptor; it mediates the "Proteolyses of Syntaxin 1A/B and SNAP- 25"; figure 3 and 4 also supported the proteolysis activity of Botulinum neurotoxin C1	challenge
requireschanges	TITSE:VMPA	2012-03-31 10:38:54 CDT	GO:0033619 membrane protein proteolysis (P)	PMID:20026600	ECO:0000314 direct assay evidence used in manual assertion	figure 1 and figure 4 demonstrated the proteolytic activity of T. serrulatus venom. Vesicle-associated membrane protein type v-SNARE proteins was cleaved upon infected with the venom	challenge
requireschanges	CORDI:Q6NJW2	2012-04-15 12:55:03 CDT	GO:0004096 catalase activity (F)	PMID:22438866	ECO:0000315 mutant phenotype evidence used in manual assertion	figure 1A and 1B demonstrated that C7(beta) needed the cat gene in order for survival. The mutant strains was not able to survive after deletion of the cat gene, they were not able to detoxifiy when hydrogen peroxide added, complete loss of viability was shown.	challenge
requireschanges	CORDI:H2H804	2012-04-15 13:05:37 CDT	GO:0010629 negative regulation of gene expression (figure 4 and figure 5 demonstrated how oxyR downregulate the transcription of cat gene, this is shown by the doing a quantitative RT-PCR assays on catalase activty and comparing wild-type strains and mutant strains with deletion of oxyR mutants)	PMID:22438866	IDA: Inferred from Direct Assay		challenge
requireschanges	CORDI:Y733	2012-04-15 13:37:09 CDT	GO:0030047 actin modification (P)	PMID:22239957	ECO:0000270 expression pattern evidence used in manual assertion	figure 5A demonstrated the "cytoskeletal changes with accumulation of polymerized actin in Hep-2 cells" by the presence of the protein 67-72p	challenge

acceptable:4
unacceptable:0
requires_changes:7
flagged:0

Annotations challenged by Ha856981

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
requireschanges	Al271843, Team Frederick Griffith	LACAC:Q5FI04	GO:0050082 - maltose phosphorylase activity (F)	PMID:20713411	ECO:0000270 expression pattern evidence used in manual assertion	challenge	C: 1

0 annotations fixed by Ha856981

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
requireschanges	NEIM8:C9X1X6	2012-02-25 13:06:36 CST	GO:0016337 cell-cell adhesion (cells were monitored prior to infection. No adhesion to the ME180 epithelial cells was observed until the expression of PilC was induced - Figure 3. Both PilC1 and PilC2 induced adhesion to epithelial cells )	PMID:19718432	IDA: Inferred from Direct Assay		challenge
updatedbyinstructor	STREE:Q9KGU0	2012-02-25 13:27:55 CST	GO:0007155 cell adhesion (P)	PMID:21602213	ECO:0000314 direct assay evidence used in manual assertion	Figure 6 - Assay demonstrated that "BgaA contributes to the adherence of encapsulated pneumococci to human epithelial cells"	challenge

acceptable:0
unacceptable:0
requires_changes:1
flagged:0

Annotations challenged by Ha856981

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
requireschanges	Al271843, Team Frederick Griffith	LACAC:Q5FI04	GO:0050082 - maltose phosphorylase activity (F)	PMID:20713411	ECO:0000270 expression pattern evidence used in manual assertion	challenge	C: 1

0 annotations fixed by Ha856981