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Category:Team Martha Chase

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
requireschangesCORDI:Y733Ha856981, Team Martha Chase2012-04-15 13:37:09 CDTGO:0030047 actin modification (P)PMID:22239957ECO:0000270 expression pattern evidence used in manual assertion

figure 5A demonstrated the "cytoskeletal changes with accumulation of polymerized actin in Hep-2 cells" by the presence of the protein 67-72p

challenge
requireschangesCORDI:H2H804Ha856981, Team Martha Chase2012-04-15 13:05:37 CDTGO:0010629 negative regulation of gene expression (figure 4 and figure 5 demonstrated how oxyR downregulate the transcription of cat gene, this is shown by the doing a quantitative RT-PCR assays on catalase activty and comparing wild-type strains and mutant strains with deletion of oxyR mutants)PMID:22438866IDA: Inferred from Direct Assay
challenge
requireschangesCORDI:Q6NJW2Ha856981, Team Martha Chase2012-04-15 12:55:03 CDTGO:0004096 catalase activity (F)PMID:22438866ECO:0000315 mutant phenotype evidence used in manual assertion

figure 1A and 1B demonstrated that C7(beta) needed the cat gene in order for survival. The mutant strains was not able to survive after deletion of the cat gene, they were not able to detoxifiy when hydrogen peroxide added, complete loss of viability was shown.

challenge
requireschangesTITSE:VMPAHa856981, Team Martha Chase2012-03-31 10:38:54 CDTGO:0033619 membrane protein proteolysis (P)PMID:20026600ECO:0000314 direct assay evidence used in manual assertion

figure 1 and figure 4 demonstrated the proteolytic activity of T. serrulatus venom. Vesicle-associated membrane protein type v-SNARE proteins was cleaved upon infected with the venom

challenge
acceptableCLOBO:BXC1Ha856981, Team Martha Chase2012-03-31 10:25:21 CDTGO:0033619 membrane protein proteolysis (P)PMID:8611567ECO:0000314 direct assay evidence used in manual assertion

figure 1 demonstrated that when botulinum toxin BoNT binds to receptor; it mediates the "Proteolyses of Syntaxin 1A/B and SNAP- 25"; figure 3 and 4 also supported the proteolysis activity of Botulinum neurotoxin C1

challenge
acceptableCLOBO:BXC1Ha856981, Team Martha Chase2012-03-31 10:20:27 CDTGO:0045955 negative regulation of calcium ion-dependent exocytosis (P)PMID:8611567ECO:0000314 direct assay evidence used in manual assertion

figure 1 demonstrated the induced inhibition of catecholamine release detected by immunoassay

challenge
requireschangesCLOTE:TETXHa856981, Team Martha Chase2012-03-31 10:08:17 CDTGO:0033619 membrane protein proteolysis (P)PMID:22392932ECO:0000314 direct assay evidence used in manual assertion

"Figure 8 demonstrated TeNT cleavage of VAMP2 (Vesicle-associated membrane protein 2) in rat cortical neurons."

challenge
requireschangesBACAN:Q81JD7Ha856981, Team Martha Chase2012-03-29 16:41:13 CDTGO:0006958 complement activation, classical pathway (P)PMID:22442442ECO:0000314 direct assay evidence used in manual assertion

figure 5 demonstrated that the presence of BclA protein significantly enhance the C3 deposition on the spore surface; C3 is a critical components in classical complement pathway

challenge
acceptableBACAN:Q81JD7Ha856981, Team Martha Chase2012-03-29 16:40:57 CDTGO:0050764 regulation of phagocytosis (P)PMID:22442442ECO:0000314 direct assay evidence used in manual assertion

Figure 7 "suggested BclA is required for complement-mediated phagocytosis of spores"

challenge
acceptableBACAN:LEFHa856981, Team Martha Chase2012-03-29 15:47:24 CDTGO:0009405 pathogenesis (P)PMID:22438953ECO:0000270 expression pattern evidence used in manual assertion

figure 2 - "in time course study, lethal toxin-induced pathological changes became evident in the intestine 48 hours post lethal toxin exposure. these changes included the onset of villous damage and minor hemorrhage. by 72 hours post lethal toxin exposure, focal areas showed marked destruction of the normal villous structures, accompanied by ares ulceration"

challenge
requireschangesBACAN:LEFHa856981, Team Martha Chase2012-03-29 15:39:43 CDTGO:0006508 proteolysis (P)PMID:22438953ECO:0000314 direct assay evidence used in manual assertion

figure 5 demonstrated that "the specific proteolytic activity of lethal factor of the MKKs is required for the anti-proliferate and pro-apoptotic effects of lethal toxin on the intestinal epithelium" ; the data also established the proteolysis activity of lethal factor of Anthrax lethal toxin

challenge
updatedbyinstructorBORBG:OSPA7Ha856981, Team Martha Chase2012-03-26 15:00:12 CDTGO:0007155 cell adhesion (P)PMID:22355605ECO:0000314 direct assay evidence used in manual assertion

figure 2 demonstrated the adhesion of OspA proteins to CD40 molecules in brain-microvascular endothelia cells, showing that Correlial adhesion to the endothelial cells

challenge

Pages in category "Team Martha Chase"

The following 3 pages are in this category, out of 3 total.


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