CLOBO:BXC1

Species (Taxon ID)	Clostridium botulinum. (1491)
Gene Name(s)	No Information Provided.
Protein Name(s)	Botulinum neurotoxin type C1 BoNT/C1 Bontoxilysin-C1 Botulinum neurotoxin C1 light chain Botulinum neurotoxin C1 heavy chain
External Links
UniProt	P18640
EMBL	X66433 X72793 X53751 D90210 X62389
PDB	2QN0 3DEB 3N7K 3R4S 3R4U
PDBsum	2QN0 3DEB 3N7K 3R4S 3R4U
ProteinModelPortal	P18640
SMR	P18640
MEROPS	M27.002
BRENDA	3.4.24.69
Reactome	REACT_200658
EvolutionaryTrace	P18640
GO	GO:0044164 GO:0044156 GO:0044231 GO:0016021 GO:0004222 GO:0008270 GO:0051609 GO:0033619 GO:0045955 GO:0007269 GO:0009405 GO:0007268
Gene3D	2.60.120.200 3.90.1240.10
InterPro	IPR000395 IPR013320 IPR011065 IPR013104 IPR012928 IPR012500
Pfam	PF01742 PF07951 PF07953 PF07952
PRINTS	PR00760
SUPFAM	SSF49899 SSF50386
PROSITE	PS00142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045955	negative regulation of calcium ion-dependent exocytosis	PMID:8611567	ECO:0000314			P		figure 1 demonstrated the induced inhibition of catecholamine release detected by immunoassay	complete CACAO 4133
	GO:0033619	membrane protein proteolysis	PMID:8611567	ECO:0000314			P		figure 1 demonstrated that when botulinum toxin BoNT binds to receptor; it mediates the "Proteolyses of Syntaxin 1A/B and SNAP- 25"; figure 3 and 4 also supported the proteolysis activity of Botulinum neurotoxin C1	complete CACAO 4134
enables	GO:0090729	toxin activity		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046929	negative regulation of neurotransmitter secretion		ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035594	ganglioside binding		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045955	negative regulation of calcium ion-dependent exocytosis	PMID:8611567	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033619	membrane protein proteolysis	PMID:8611567	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071806	protein transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008320	P		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012928	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395	F		Seeded From UniProt	complete
enables	GO:0008320	protein transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012500	F		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012500 InterPro:IPR012928	P		Seeded From UniProt	complete
involved_in	GO:0046929	negative regulation of neurotransmitter secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000395 InterPro:IPR012500 InterPro:IPR012928 InterPro:IPR013104	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0090729	toxin activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0800	F		Seeded From UniProt	complete
edit table

References

See Help:References for how to manage references in GONUTS.