| unacceptable | HUMAN:RRAS | 2016-04-11 11:18:14 CDT | GO:0045785 positive regulation of cell adhesion (P) | PMID:22825554 | ECO:0000315 mutant phenotype evidence used in manual assertion | Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras.
| challenge |
| updatedbyinstructor | HUMAN:RIN2 | 2016-04-11 11:23:07 CDT | GO:1904906 positive regulation of endothelial cell-matrix adhesion via fibronectin (P) | PMID:22825554 | ECO:0000315 mutant phenotype evidence used in manual assertion | Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras.
| challenge |
| updatedbyinstructor | HUMAN:RRAS | 2016-04-11 11:34:17 CDT | GO:0010595 positive regulation of endothelial cell migration (P) | PMID:22825554 | ECO:0000315 mutant phenotype evidence used in manual assertion | Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras.
| challenge |
| updatedbyinstructor | HUMAN:RRAS | 2016-04-11 11:34:17 CDT | GO:2001214 positive regulation of vasculogenesis (P) | PMID:22825554 | ECO:0000315 mutant phenotype evidence used in manual assertion | Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras.
| challenge |
| updatedbyinstructor | HUMAN:RRAS | 2016-04-11 11:34:17 CDT | GO:1904906 positive regulation of endothelial cell-matrix adhesion via fibronectin (P) | PMID:22825554 | ECO:0000315 mutant phenotype evidence used in manual assertion | Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras.
| challenge |
| updatedbyinstructor | HUMAN:RIN2 | 2016-04-11 11:39:03 CDT | GO:0010595 positive regulation of endothelial cell migration (P) | PMID:22825554 | ECO:0000315 mutant phenotype evidence used in manual assertion | Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras.
| challenge |
| updatedbyinstructor | HUMAN:RIN2 | 2016-04-11 11:39:03 CDT | GO:2001214 positive regulation of vasculogenesis (P) | PMID:22825554 | ECO:0000315 mutant phenotype evidence used in manual assertion | Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras.
| challenge |
| unacceptable | HUMAN:RIN2 | 2016-04-11 11:39:03 CDT | GO:0050840 extracellular matrix binding (F) | PMID:22825554 | ECO:0000315 mutant phenotype evidence used in manual assertion | Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras.
| challenge |
| unacceptable | STAAU:AURE | 2016-04-13 06:33:18 CDT | GO:0090609 single-species submerged biofilm formation (P) | PMID:25257373 | ECO:0000315 mutant phenotype evidence used in manual assertion | Figure 6 shows the impact of mutations in individual protease genes/operons on biofilm formation in vitro. The relative capacity to form a biofilm was assessed using a microtiter plate assay as previously described (Beenken et al. 2003) using FPR3757, its sarA mutant, and its sarA mutant carrying mutations in the indicated protease genes. Single asterisks indicate significance by comparison to the parent strain. Double asterisks indicate significance by comparison to the sarA mutant. As a control, biofilm formation was also assessed in LAC, its sarA mutant, and derivatives of thesarA mutant unable to produce aureolysin (Saur), unable to produce any extracellular protease (SP), or unable to produce any extracellular protease other than those encoded by the spl operon (SPspl+). Single asterisk indicates statistical significance by comparison to the sarA mutant. Double asterisks indicate significance by comparison to the Saur mutant.
| challenge |
| unacceptable | STAAU:SSPA | 2016-04-13 06:35:20 CDT | GO:0090609 single-species submerged biofilm formation (P) | PMID:25257373 | ECO:0000315 mutant phenotype evidence used in manual assertion | Figure 6 shows the impact of mutations in individual protease genes/operons on biofilm formation in vitro. The relative capacity to form a biofilm was assessed using a microtiter plate assay as previously described (Beenken et al. 2003) using FPR3757, its sarA mutant, and its sarA mutant carrying mutations in the indicated protease genes. Single asterisks indicate significance by comparison to the parent strain. Double asterisks indicate significance by comparison to the sarA mutant. As a control, biofilm formation was also assessed in LAC, its sarA mutant, and derivatives of thesarA mutant unable to produce aureolysin (Saur), unable to produce any extracellular protease (SP), or unable to produce any extracellular protease other than those encoded by the spl operon (SPspl+). Single asterisk indicates statistical significance by comparison to the sarA mutant. Double asterisks indicate significance by comparison to the Saur mutant.
| challenge |
| unacceptable | STAA3:A0A0G2Q3K2 | 2016-04-13 06:36:16 CDT | GO:0090609 single-species submerged biofilm formation (P) | PMID:25257373 | ECO:0000315 mutant phenotype evidence used in manual assertion | Figure 6 shows the impact of mutations in individual protease genes/operons on biofilm formation in vitro. The relative capacity to form a biofilm was assessed using a microtiter plate assay as previously described (Beenken et al. 2003) using FPR3757, its sarA mutant, and its sarA mutant carrying mutations in the indicated protease genes. Single asterisks indicate significance by comparison to the parent strain. Double asterisks indicate significance by comparison to the sarA mutant. As a control, biofilm formation was also assessed in LAC, its sarA mutant, and derivatives of thesarA mutant unable to produce aureolysin (Saur), unable to produce any extracellular protease (SP), or unable to produce any extracellular protease other than those encoded by the spl operon (SPspl+). Single asterisk indicates statistical significance by comparison to the sarA mutant. Double asterisks indicate significance by comparison to the Saur mutant.
| challenge |
