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HUMAN:RRAS

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RRAS
Protein Name(s) Ras-related protein R-Ras

p23

External Links
UniProt P10301
EMBL M14949
M14948
AF493920
BT006805
CR541944
CR541967
CH471177
BC016286
BC016318
CCDS CCDS12774.1
PIR A26159
RefSeq NP_006261.1
UniGene Hs.515536
PDB 2FN4
PDBsum 2FN4
ProteinModelPortal P10301
SMR P10301
BioGrid 112151
IntAct P10301
STRING 9606.ENSP00000246792
PhosphoSite P10301
DMDM 133486
SWISS-2DPAGE P10301
MaxQB P10301
PaxDb P10301
PeptideAtlas P10301
PRIDE P10301
DNASU 6237
Ensembl ENST00000246792
GeneID 6237
KEGG hsa:6237
UCSC uc002pop.1
CTD 6237
GeneCards GC19M050138
HGNC HGNC:10447
HPA CAB010160
MIM 165090
neXtProt NX_P10301
PharmGKB PA34861
eggNOG COG1100
GeneTree ENSGT00770000120464
HOGENOM HOG000233973
HOVERGEN HBG009351
InParanoid P10301
KO K07829
OMA FGASHHV
OrthoDB EOG7QVM41
PhylomeDB P10301
TreeFam TF312796
Reactome REACT_19266
REACT_19279
REACT_20568
SignaLink P10301
EvolutionaryTrace P10301
GeneWiki RRAS
GenomeRNAi 6237
NextBio 24215
PRO PR:P10301
Proteomes UP000005640
Bgee P10301
CleanEx HS_RRAS
ExpressionAtlas P10301
Genevestigator P10301
GO GO:0070062
GO:0005925
GO:0005886
GO:0019003
GO:0005525
GO:0003924
GO:0032403
GO:0007411
GO:0060325
GO:0006184
GO:0002521
GO:0030336
GO:0045766
GO:0007265
GO:0070372
GO:0051896
GO:0007268
Gene3D 3.40.50.300
InterPro IPR027417
IPR005225
IPR001806
IPR020849
PANTHER PTHR24070
Pfam PF00071
PRINTS PR00449
SMART SM00173
SUPFAM SSF52540
TIGRFAMs TIGR00231
PROSITE PS51421

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0002521

leukocyte differentiation

PMID:24705357[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060325

face morphogenesis

PMID:24705357[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070372

regulation of ERK1 and ERK2 cascade

PMID:24705357[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051896

regulation of protein kinase B signaling

PMID:24705357[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:24705357[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019003

GDP binding

PMID:24705357[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005925

focal adhesion

PMID:21423176[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

GO:0045785

positive regulation of cell adhesion

PMID:22825554[3]

ECO:0000315

P

Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras.

complete
CACAO 11689

part_of

GO:0070062

extracellular exosome

PMID:19056867[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

GO:0010595

positive regulation of endothelial cell migration

PMID:22825554[3]

ECO:0000315

P

Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras.

complete
CACAO 11691

involved_in

GO:0045766

positive regulation of angiogenesis

PMID:21393242[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

GO:2001214

positive regulation of vasculogenesis

PMID:22825554[3]

ECO:0000315

P

Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras.

complete
CACAO 11692

enables

GO:0019003

GDP binding

PMID:16773572[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:1904906

positive regulation of endothelial cell-matrix adhesion via fibronectin

PMID:22825554[3]

ECO:0000315

P

Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras.

complete
CACAO 11693

enables

GO:0003924

GTPase activity

PMID:16773572[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

PMID:23209302[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030336

negative regulation of cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10833
ensembl:ENSMUSP00000042150

P

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001806

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001806
InterPro:IPR005225
InterPro:IPR020849

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020849

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020849

C

Seeded From UniProt

complete

involved_in

GO:0007265

Ras protein signal transduction

PMID:3098437[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:3098437[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-416546

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Flex, E et al. (2014) Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis. Hum. Mol. Genet. 23 4315-27 PubMed GONUTS page
  2. Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Sandri, C et al. (2012) The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Cell Res. 22 1479-501 PubMed GONUTS page
  4. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  5. Wilson, LS et al. (2011) A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells. J. Biol. Chem. 286 16285-96 PubMed GONUTS page
  6. 6.0 6.1 Carta, C et al. (2006) Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. Am. J. Hum. Genet. 79 129-35 PubMed GONUTS page
  7. Ahmed, SM et al. (2012) KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J. Cell Biol. 199 951-67 PubMed GONUTS page
  8. 8.0 8.1 Lowe, DG et al. (1987) Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. Cell 48 137-46 PubMed GONUTS page