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HUMAN:RRAS
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | RRAS | |
| Protein Name(s) | Ras-related protein R-Ras
p23 | |
| External Links | ||
| UniProt | P10301 | |
| EMBL | M14949 M14948 AF493920 BT006805 CR541944 CR541967 CH471177 BC016286 BC016318 | |
| CCDS | CCDS12774.1 | |
| PIR | A26159 | |
| RefSeq | NP_006261.1 | |
| UniGene | Hs.515536 | |
| PDB | 2FN4 | |
| PDBsum | 2FN4 | |
| ProteinModelPortal | P10301 | |
| SMR | P10301 | |
| BioGrid | 112151 | |
| IntAct | P10301 | |
| STRING | 9606.ENSP00000246792 | |
| PhosphoSite | P10301 | |
| DMDM | 133486 | |
| SWISS-2DPAGE | P10301 | |
| MaxQB | P10301 | |
| PaxDb | P10301 | |
| PeptideAtlas | P10301 | |
| PRIDE | P10301 | |
| DNASU | 6237 | |
| Ensembl | ENST00000246792 | |
| GeneID | 6237 | |
| KEGG | hsa:6237 | |
| UCSC | uc002pop.1 | |
| CTD | 6237 | |
| GeneCards | GC19M050138 | |
| HGNC | HGNC:10447 | |
| HPA | CAB010160 | |
| MIM | 165090 | |
| neXtProt | NX_P10301 | |
| PharmGKB | PA34861 | |
| eggNOG | COG1100 | |
| GeneTree | ENSGT00770000120464 | |
| HOGENOM | HOG000233973 | |
| HOVERGEN | HBG009351 | |
| InParanoid | P10301 | |
| KO | K07829 | |
| OMA | FGASHHV | |
| OrthoDB | EOG7QVM41 | |
| PhylomeDB | P10301 | |
| TreeFam | TF312796 | |
| Reactome | REACT_19266 REACT_19279 REACT_20568 | |
| SignaLink | P10301 | |
| EvolutionaryTrace | P10301 | |
| GeneWiki | RRAS | |
| GenomeRNAi | 6237 | |
| NextBio | 24215 | |
| PRO | PR:P10301 | |
| Proteomes | UP000005640 | |
| Bgee | P10301 | |
| CleanEx | HS_RRAS | |
| ExpressionAtlas | P10301 | |
| Genevestigator | P10301 | |
| GO | GO:0070062 GO:0005925 GO:0005886 GO:0019003 GO:0005525 GO:0003924 GO:0032403 GO:0007411 GO:0060325 GO:0006184 GO:0002521 GO:0030336 GO:0045766 GO:0007265 GO:0070372 GO:0051896 GO:0007268 | |
| Gene3D | 3.40.50.300 | |
| InterPro | IPR027417 IPR005225 IPR001806 IPR020849 | |
| PANTHER | PTHR24070 | |
| Pfam | PF00071 | |
| PRINTS | PR00449 | |
| SMART | SM00173 | |
| SUPFAM | SSF52540 | |
| TIGRFAMs | TIGR00231 | |
| PROSITE | PS51421 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0002521 |
leukocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060325 |
face morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070372 |
regulation of ERK1 and ERK2 cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051896 |
regulation of protein kinase B signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003924 |
GTPase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019003 |
GDP binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005925 |
focal adhesion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
| GO:0045785 |
positive regulation of cell adhesion |
ECO:0000315 |
P |
Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras. |
complete | |||||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
| GO:0010595 |
positive regulation of endothelial cell migration |
ECO:0000315 |
P |
Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras. |
complete | |||||
|
involved_in |
GO:0045766 |
positive regulation of angiogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:2001214 |
positive regulation of vasculogenesis |
ECO:0000315 |
P |
Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras. |
complete | |||||
|
enables |
GO:0019003 |
GDP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:1904906 |
positive regulation of endothelial cell-matrix adhesion via fibronectin |
ECO:0000315 |
P |
Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras. |
complete | |||||
|
enables |
GO:0003924 |
GTPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030336 |
negative regulation of cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P10833 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003924 |
GTPase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007265 |
Ras protein signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003924 |
GTPase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-416546 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Flex, E et al. (2014) Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis. Hum. Mol. Genet. 23 4315-27 PubMed GONUTS page
- ↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Sandri, C et al. (2012) The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Cell Res. 22 1479-501 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Wilson, LS et al. (2011) A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells. J. Biol. Chem. 286 16285-96 PubMed GONUTS page
- ↑ 6.0 6.1 Carta, C et al. (2006) Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. Am. J. Hum. Genet. 79 129-35 PubMed GONUTS page
- ↑ Ahmed, SM et al. (2012) KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J. Cell Biol. 199 951-67 PubMed GONUTS page
- ↑ 8.0 8.1 Lowe, DG et al. (1987) Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. Cell 48 137-46 PubMed GONUTS page
p
- GO:0005886 ! plasma membrane
- GO:1904906 ! positive regulation of endothelial cell-matrix adhesion
- GO:2001214 ! positive regulation of vasculogenesis
- GO:0045766 ! positive regulation of angiogenesis
- GO:0010595 ! positive regulation of endothelial cell migration
- GO:0045785 ! positive regulation of cell adhesion
- Primates
- GO:0044877 ! protein-containing complex binding
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