STAAU:SSPA

Species (Taxon ID)	Staphylococcus aureus. (1280)
Gene Name(s)	sspA
Protein Name(s)	Glutamyl endopeptidase Endoproteinase Glu-C Staphylococcal serine proteinase V8 protease V8 proteinase
External Links
UniProt	P0C1U8
EMBL	Y00356
PIR	A26812
RefSeq	WP_000676548.1
PDB	1WCZ
PDBsum	1WCZ
ProteinModelPortal	P0C1U8
SMR	P0C1U8
STRING	93062.SACOL1057
BindingDB	P0C1U8
ChEMBL	CHEMBL5115
MEROPS	S01.269
PRIDE	P0C1U8
eggNOG	ENOG4108CHM COG3591
EvolutionaryTrace	P0C1U8
GO	GO:0005576 GO:0004252 GO:0009405
InterPro	IPR009003 IPR008256 IPR008353 IPR001254 IPR028301 IPR000126
PRINTS	PR01774 PR00839
SMART	SM00020
SUPFAM	SSF50494
PROSITE	PS00672 PS00673

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0090609	single-species submerged biofilm formation	PMID:25257373	ECO:0000315			P		Figure 6 shows the impact of mutations in individual protease genes/operons on biofilm formation in vitro. The relative capacity to form a biofilm was assessed using a microtiter plate assay as previously described (Beenken et al. 2003) using FPR3757, its sarA mutant, and its sarA mutant carrying mutations in the indicated protease genes. Single asterisks indicate significance by comparison to the parent strain. Double asterisks indicate significance by comparison to the sarA mutant. As a control, biofilm formation was also assessed in LAC, its sarA mutant, and derivatives of thesarA mutant unable to produce aureolysin (Saur), unable to produce any extracellular protease (SP), or unable to produce any extracellular protease other than those encoded by the spl operon (SPspl+). Single asterisk indicates statistical significance by comparison to the sarA mutant. Double asterisks indicate significance by comparison to the Saur mutant.	complete CACAO 11740
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008353	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000126 InterPro:IPR008256 InterPro:IPR008353	P		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000126 InterPro:IPR008256	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0720	F		Seeded From UniProt	complete
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References

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