STAAU:AURE

Species (Taxon ID)	Staphylococcus aureus. (1280)
Gene Name(s)	aur
Protein Name(s)	Zinc metalloproteinase aureolysin Staphylococcus aureus neutral proteinase
External Links
UniProt	P81177
EMBL	AJ249166 AJ249167
PDB	1BQB
PDBsum	1BQB
ProteinModelPortal	P81177
SMR	P81177
MEROPS	M04.009
eggNOG	COG3227
EvolutionaryTrace	P81177
GO	GO:0046872 GO:0004222
Gene3D	3.10.170.10
InterPro	IPR011096 IPR025711 IPR023612 IPR001570 IPR013856
Pfam	PF07504 PF03413 PF01447 PF02868
PRINTS	PR00730
PROSITE	PS00142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0090609	single-species submerged biofilm formation	PMID:25257373	ECO:0000315			P		Figure 6 shows the impact of mutations in individual protease genes/operons on biofilm formation in vitro. The relative capacity to form a biofilm was assessed using a microtiter plate assay as previously described (Beenken et al. 2003) using FPR3757, its sarA mutant, and its sarA mutant carrying mutations in the indicated protease genes. Single asterisks indicate significance by comparison to the parent strain. Double asterisks indicate significance by comparison to the sarA mutant. As a control, biofilm formation was also assessed in LAC, its sarA mutant, and derivatives of thesarA mutant unable to produce aureolysin (Saur), unable to produce any extracellular protease (SP), or unable to produce any extracellular protease other than those encoded by the spl operon (SPspl+). Single asterisk indicates statistical significance by comparison to the sarA mutant. Double asterisks indicate significance by comparison to the Saur mutant.	complete CACAO 11739
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001570 InterPro:IPR013856 InterPro:IPR023612	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023612	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
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References

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