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HUMAN:RIN2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | RIN2 (synonyms: RASSF4) | |
| Protein Name(s) | Ras and Rab interactor 2
Ras association domain family 4 Ras inhibitor JC265 Ras interaction/interference protein 2 | |
| External Links | ||
| UniProt | Q8WYP3 | |
| EMBL | AB060339 AL049538 AL132821 AL132821 AL049538 AK094884 AL136924 M37190 | |
| CCDS | CCDS56182.1 | |
| PIR | B38637 | |
| RefSeq | NP_001229510.1 NP_061866.1 XP_005260788.1 XP_006723637.1 XP_006723638.1 XP_006723640.1 XP_011527559.1 XP_011527560.1 | |
| UniGene | Hs.472270 Hs.733605 | |
| ProteinModelPortal | Q8WYP3 | |
| SMR | Q8WYP3 | |
| BioGrid | 119960 | |
| IntAct | Q8WYP3 | |
| MINT | MINT-1493616 | |
| STRING | 9606.ENSP00000255006 | |
| iPTMnet | Q8WYP3 | |
| PhosphoSite | Q8WYP3 | |
| BioMuta | RIN2 | |
| DMDM | 28201876 | |
| MaxQB | Q8WYP3 | |
| PaxDb | Q8WYP3 | |
| PRIDE | Q8WYP3 | |
| Ensembl | ENST00000255006 | |
| GeneID | 54453 | |
| KEGG | hsa:54453 | |
| UCSC | uc002wro.3 | |
| CTD | 54453 | |
| GeneCards | RIN2 | |
| HGNC | HGNC:18750 | |
| HPA | HPA034641 | |
| MalaCards | RIN2 | |
| MIM | 610222 613075 | |
| neXtProt | NX_Q8WYP3 | |
| Orphanet | 217335 | |
| PharmGKB | PA38672 | |
| eggNOG | KOG2320 ENOG410ZZW5 | |
| GeneTree | ENSGT00530000063053 | |
| HOVERGEN | HBG023719 | |
| InParanoid | Q8WYP3 | |
| OMA | ESRPPCH | |
| OrthoDB | EOG7PZRWP | |
| PhylomeDB | Q8WYP3 | |
| TreeFam | TF331067 | |
| ChiTaRS | RIN2 | |
| GenomeRNAi | 54453 | |
| NextBio | 56681 | |
| PRO | PR:Q8WYP3 | |
| Proteomes | UP000005640 | |
| Bgee | Q8WYP3 | |
| CleanEx | HS_RASSF4 HS_RIN2 | |
| ExpressionAtlas | Q8WYP3 | |
| Genevisible | Q8WYP3 | |
| GO | GO:0005737 GO:0005096 GO:0030695 GO:0017112 GO:0006897 GO:0043547 GO:0050790 GO:0007264 | |
| Gene3D | 3.30.505.10 | |
| InterPro | IPR000159 IPR000980 IPR029071 IPR003123 | |
| Pfam | PF00788 PF02204 | |
| SMART | SM00314 SM00252 SM00167 | |
| SUPFAM | SSF54236 SSF55550 | |
| PROSITE | PS50200 PS50001 PS51205 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:1904906 |
positive regulation of endothelial cell-matrix adhesion via fibronectin |
ECO:0000315 |
P |
Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras. |
complete | |||||
| GO:0010595 |
positive regulation of endothelial cell migration |
ECO:0000315 |
P |
Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras. |
complete | |||||
| GO:2001214 |
positive regulation of vasculogenesis |
ECO:0000315 |
P |
Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras. |
complete | |||||
| GO:0050840 |
extracellular matrix binding |
ECO:0000315 |
F |
Figure 1. R-Ras and RIN2 promote EC-to-ECM binding, adhesion, migration, and vascular morphogenesis; RIN2 mediates the pro-adhesive effects of R-Ras. |
complete | |||||
|
enables |
GO:0017112 |
Rab guanyl-nucleotide exchange factor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007264 |
small GTPase mediated signal transduction |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005575 |
cellular_component |
ECO:0000307 |
no biological data found used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030695 |
GTPase regulator activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005096 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050790 |
regulation of catalytic activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0030695 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-8875320 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006897 |
endocytosis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Sandri, C et al. (2012) The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Cell Res. 22 1479-501 PubMed GONUTS page
- ↑ Saito, K et al. (2002) A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. J. Biol. Chem. 277 3412-8 PubMed GONUTS page
- ↑ 3.0 3.1 Colicelli, J et al. (1991) Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 88 2913-7 PubMed GONUTS page
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