User:Bhatt001

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
acceptable	HUMAN:FIBG	2012-02-12 14:43:04 CST	GO:0005577 fibrinogen complex (C)	PMID:6451630	ECO:0000314 direct assay evidence used in manual assertion	Figure 6. Shows the presence of two binding sites for the D1 peptide on the NH-2 terminal region of the fibrin monomer.	challenge
acceptable	HUMAN:ATP5E	2012-02-12 16:28:32 CST	GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) (C)	PMID:20566710	ECO:0000315 mutant phenotype evidence used in manual assertion	In the paragraph labeled "Low content of ATP synthase subunit ε, but increased content of subunit c is present in patient mitochondria". Figure 6 shows the patient mitochondria with accumulated Fo subunit c of ATP synthase. Figure 5 shows a mutated subunit ε is incorporated in the ATP synthase complex.	challenge
requireschanges	HUMAN:TNNT2	2012-02-25 19:16:27 CST	GO:0005861 troponin complex (C)	PMID:7898523	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 3 shows compared with patients with β cardiac myosin heavy-chain mutations, patients with cardiac troponin T mutations had a higher incidence of death before the age of 30 years. Table 3 shows each cardiac troponin T mutation produced an increase in the maximal thickness of the left ventricular wall.	challenge
acceptable	HUMAN:MYOTI	2012-02-25 19:52:22 CST	GO:0030018 Z disc (C)	PMID:10958653	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 2d shows LGMD1A muscle exhibiting patches of striking Z-line irregularity.	challenge
requireschanges	HUMAN:MYOF	2012-02-26 15:38:27 CST	GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway (P)	PMID:17702744	ECO:0000314 direct assay evidence used in manual assertion	Figure 2 shows EC deficient in myoferlin which show defective membrane repair. Figure 3 shows that myoferlin down-regulation disrupts VEGF intracellular signaling pathways through VEGFR-2 degradation.	challenge
requireschanges	HUMAN:PRKN2	2012-03-11 17:08:39 CDT	GO:0004842 ubiquitin-protein ligase activity (F)	PMID:11078524	ECO:0000314 direct assay evidence used in manual assertion	Figure 3C shows that Cys421Ala and Cys431Ala mutations significantly decrease the self-ubiquitination of Parkin.	challenge
requireschanges	HUMAN:PRKN2	2012-03-11 17:08:39 CDT	GO:0004842 ubiquitin-protein ligase activity (F)	PMID:11078524	ECO:0000314 direct assay evidence used in manual assertion	Figure 1B shows that Parkin selectively interacts with UbcH8.	challenge
acceptable	HUMAN:PRKN2	2012-03-11 17:19:16 CDT	GO:0004842 ubiquitin-protein ligase activity (F)	PMID:11078524	ECO:0000314 direct assay evidence used in manual assertion	Figure 4C shows that ubiquitination of CDCrel-1 is significantly increased in the presence of Parkin.	challenge
acceptable	HUMAN:SNCAP	2012-03-26 20:09:16 CDT	GO:0008219 cell death (P)	PMID:16595633	ECO:0000314 direct assay evidence used in manual assertion	Figure 4C shows that synphilin-1A promotes the death of ≈20% of the transfected neurons after 72 hours.	challenge
requireschanges	HUMAN:SERPH	2012-04-01 17:38:58 CDT	GO:0005783 endoplasmic reticulum (C)	PMID:20188343	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 3	challenge
requireschanges	HUMAN:H2A1	2012-04-10 12:10:26 CDT	GO:0016574 histone ubiquitination (P)	PMID:18001825	ECO:0000314 direct assay evidence used in manual assertion	Figure 6 shows RNF8 is required for H2AX ubiquitylation following DNA damage.	challenge
acceptable	CUPNH:HMP	2012-04-14 19:34:31 CDT	GO:0008941 nitric oxide dioxygenase activity (F)	PMID:10922365	ECO:0000314 direct assay evidence used in manual assertion	Figure 6 shows the effects of FAD on the NOD activities of flavoHbs. This suggests dissociation and reassociation of bound FAD during enzyme turnover.	challenge

acceptable:6
unacceptable:0
requires_changes:6
flagged:0

Annotations challenged by Bhatt001

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
requireschanges	Bagal001, Team Multi Drug Resistance	MYCTU:INIA	GO:0005622 - intracellular anatomical structure (C)	PMID:15752203[5]	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 2

0 annotations fixed by Bhatt001