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HUMAN:SNCAP
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SNCAIP | |
| Protein Name(s) | Synphilin-1
Sph1 Alpha-synuclein-interacting protein | |
| External Links | ||
| UniProt | Q9Y6H5 | |
| EMBL | AF076929 AF167306 AF167301 AF167302 AF167303 AF167304 AF167305 DQ227317 CH471086 AB110788 AB110789 AB110790 CH471086 BC033743 BC040552 BC094759 | |
| CCDS | CCDS4131.1 CCDS58964.1 | |
| RefSeq | NP_001229864.1 NP_005451.2 XP_006714798.1 | |
| UniGene | Hs.426463 | |
| PDB | 2KES | |
| PDBsum | 2KES | |
| ProteinModelPortal | Q9Y6H5 | |
| SMR | Q9Y6H5 | |
| BioGrid | 114986 | |
| IntAct | Q9Y6H5 | |
| MINT | MINT-1380209 | |
| STRING | 9606.ENSP00000261368 | |
| ChEMBL | CHEMBL1926494 | |
| PhosphoSite | Q9Y6H5 | |
| DMDM | 205831000 | |
| PaxDb | Q9Y6H5 | |
| PRIDE | Q9Y6H5 | |
| Ensembl | ENST00000261367 ENST00000261368 ENST00000379538 ENST00000395469 | |
| GeneID | 9627 | |
| KEGG | hsa:9627 | |
| UCSC | uc003ksw.1 uc003ksx.1 uc003ksy.1 uc003ksz.1 | |
| CTD | 9627 | |
| GeneCards | GC05P121675 | |
| GeneReviews | SNCAIP | |
| H-InvDB | HIX0005121 HIX0018508 | |
| HGNC | HGNC:11139 | |
| HPA | CAB022597 HPA003266 | |
| MIM | 168600 603779 | |
| neXtProt | NX_Q9Y6H5 | |
| PharmGKB | PA35987 | |
| eggNOG | COG0666 | |
| GeneTree | ENSGT00390000001485 | |
| HOVERGEN | HBG061375 | |
| InParanoid | Q9Y6H5 | |
| KO | K04558 | |
| OMA | QWKSPDA | |
| PhylomeDB | Q9Y6H5 | |
| TreeFam | TF329095 | |
| ChiTaRS | SNCAIP | |
| EvolutionaryTrace | Q9Y6H5 | |
| GeneWiki | SNCAIP | |
| GenomeRNAi | 9627 | |
| NextBio | 36127 | |
| PMAP-CutDB | Q9Y6H5 | |
| PRO | PR:Q9Y6H5 | |
| Proteomes | UP000005640 | |
| Bgee | Q9Y6H5 | |
| CleanEx | HS_SNCAIP | |
| ExpressionAtlas | Q9Y6H5 | |
| Genevestigator | Q9Y6H5 | |
| GO | GO:0005737 GO:0043025 GO:0042734 GO:0008021 GO:0042802 GO:0031625 GO:0042417 GO:0090083 GO:0046928 | |
| Gene3D | 1.25.40.20 | |
| InterPro | IPR002110 IPR020683 | |
| Pfam | PF12796 | |
| SMART | SM00248 | |
| SUPFAM | SSF48403 | |
| PROSITE | PS50297 PS50088 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008219 |
cell death |
ECO:0000314 |
P |
Figure 4C shows that synphilin-1A promotes the death of ≈20% of the transfected neurons after 72 hours. |
complete | |||||
|
involved_in |
GO:0008219 |
cell death |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090083 |
regulation of inclusion body assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042734 |
presynaptic membrane |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046928 |
regulation of neurotransmitter secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042417 |
dopamine metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0036464 |
cytoplasmic ribonucleoprotein granule |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0008021 |
synaptic vesicle |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044267 |
cellular protein metabolic process |
Reactome:R-HSA-392499 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-5667111 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Eyal, A et al. (2006) Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients. Proc. Natl. Acad. Sci. U.S.A. 103 5917-22 PubMed GONUTS page
- ↑ Kalia, SK et al. (2004) BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Neuron 44 931-45 PubMed GONUTS page
- ↑ 3.0 3.1 Ribeiro, CS et al. (2002) Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein. J. Biol. Chem. 277 23927-33 PubMed GONUTS page
- ↑ Lim, KL et al. (2005) Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation. J. Neurosci. 25 2002-9 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Nagano, Y et al. (2003) Siah-1 facilitates ubiquitination and degradation of synphilin-1. J. Biol. Chem. 278 51504-14 PubMed GONUTS page
- ↑ Xie, YY et al. (2010) Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication. FASEB J. 24 196-205 PubMed GONUTS page
- ↑ Esposito, G et al. (2012) Synaptic vesicle trafficking and Parkinson's disease. Dev Neurobiol 72 134-44 PubMed GONUTS page
- ↑ Engelender, S et al. (1999) Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nat. Genet. 22 110-4 PubMed GONUTS page
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