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HUMAN:SERPH

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SERPINH1 (synonyms: CBP1, CBP2, HSP47, SERPINH2)
Protein Name(s) Serpin H1

47 kDa heat shock protein Arsenic-transactivated protein 3 AsTP3 Cell proliferation-inducing gene 14 protein Collagen-binding protein Colligin Rheumatoid arthritis-related antigen RA-A47

External Links
UniProt P50454
EMBL X61598
D83174
AB044778
AB044779
AY744367
AY264853
BT007094
AK122936
CH471076
BC014623
BC036298
BC070087
CCDS CCDS8239.1
PIR I52968
S20608
RefSeq NP_001193943.1
NP_001226.2
XP_006718790.1
XP_006718791.1
XP_006718792.1
UniGene Hs.596449
ProteinModelPortal P50454
SMR P50454
BioGrid 107318
IntAct P50454
MINT MINT-3018432
STRING 9606.ENSP00000350894
BindingDB P50454
ChEMBL CHEMBL5286
MEROPS I04.035
PhosphoSite P50454
DMDM 20141241
DOSAC-COBS-2DPAGE P50454
UCD-2DPAGE P50454
MaxQB P50454
PaxDb P50454
PeptideAtlas P50454
PRIDE P50454
DNASU 871
Ensembl ENST00000358171
ENST00000524558
ENST00000533603
GeneID 871
KEGG hsa:871
UCSC uc001owr.3
CTD 871
GeneCards GC11P075273
HGNC HGNC:1546
HPA CAB004441
HPA029198
MIM 600943
610504
613848
neXtProt NX_P50454
Orphanet 216812
PharmGKB PA35034
eggNOG COG4826
GeneTree ENSGT00770000120524
HOVERGEN HBG104930
InParanoid P50454
KO K09501
OMA NYEHSKI
OrthoDB EOG7GBFX4
PhylomeDB P50454
TreeFam TF343094
Reactome REACT_121139
ChiTaRS SERPINH1
GeneWiki Heat_shock_protein_47
GenomeRNAi 871
NextBio 3630
PRO PR:P50454
Proteomes UP000005640
Bgee P50454
CleanEx HS_SERPINH1
ExpressionAtlas P50454
Genevestigator P50454
GO GO:0005783
GO:0005788
GO:0005793
GO:0005615
GO:0070062
GO:0005518
GO:0044822
GO:0004867
GO:0003433
GO:0032964
GO:0030199
GO:0030198
GO:0010951
GO:0051604
GO:0030162
GO:0006986
InterPro IPR023795
IPR023796
IPR000215
PANTHER PTHR11461
Pfam PF00079
SMART SM00093
SUPFAM SSF56574
PROSITE PS00014
PS00284

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005783

endoplasmic reticulum

PMID:20188343[1]

ECO:0000315

C

Figure 3

complete
CACAO 4234

colocalizes_with

GO:0062023

collagen-containing extracellular matrix

PMID:28327460[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0002540)|part_of:(CL:0002570)|part_of:(CL:0002551)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28675934[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0003688)|part_of:(UBERON:0001911)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:25037231[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001155)

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

PMID:25204797[5]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002618)

Seeded From UniProt

complete

enables

GO:0005518

collagen binding

PMID:1309665[6]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005793

endoplasmic reticulum-Golgi intermediate compartment

PMID:15308636[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:7656593[9]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005518

collagen binding

PMID:7656593[9]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030199

collagen fibril organization

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88283
PANTHER:PTN000156131

P

Seeded From UniProt

complete

involved_in

GO:0010951

negative regulation of endopeptidase activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0028988
FB:FBgn0265137
PANTHER:PTN000156123
RGD:3249
UniProtKB:P05121
UniProtKB:P29508
UniProtKB:P35237
UniProtKB:P50452
UniProtKB:P50453
UniProtKB:Q9UIV8

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88283
PANTHER:PTN000156131
UniProtKB:P50454

C

Seeded From UniProt

complete

enables

GO:0004867

serine-type endopeptidase inhibitor activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002930
FB:FBgn0028983
FB:FBgn0028988
FB:FBgn0028990
FB:FBgn0265137
MGI:MGI:101780
MGI:MGI:106603
MGI:MGI:1277952
MGI:MGI:2445361
MGI:MGI:2683293
MGI:MGI:891970
MGI:MGI:894696
MGI:MGI:97608
PANTHER:PTN000156123
RGD:1306692
RGD:1307404
RGD:3249
RGD:3326
RGD:3748
RGD:619817
RGD:619896
RGD:619897
UniProtKB:P01009
UniProtKB:P01012
UniProtKB:P05121
UniProtKB:P05154
UniProtKB:P05155
UniProtKB:P07093
UniProtKB:P08697
UniProtKB:P35237
UniProtKB:P48594
UniProtKB:P50452
UniProtKB:P50453
UniProtKB:Q3ZEJ6
UniProtKB:Q86WD7
UniProtKB:Q90935
UniProtKB:Q96P63
UniProtKB:Q99574
UniProtKB:Q9TTE1
UniProtKB:Q9UIV8
WB:WBGene00005643

F

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051604

protein maturation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19324
ensembl:ENSMUSP00000126390

P

Seeded From UniProt

complete

enables

GO:0051082

unfolded protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19324
ensembl:ENSMUSP00000126390

F

Seeded From UniProt

complete

involved_in

GO:0032964

collagen biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19324
ensembl:ENSMUSP00000126390

P

Seeded From UniProt

complete

involved_in

GO:0030199

collagen fibril organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19324
ensembl:ENSMUSP00000126390

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19324
ensembl:ENSMUSP00000126390

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19324
ensembl:ENSMUSP00000126390

C

Seeded From UniProt

complete

involved_in

GO:0003433

chondrocyte development involved in endochondral bone morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19324
ensembl:ENSMUSP00000126390

P

Seeded From UniProt

complete

enables

GO:0004867

serine-type endopeptidase inhibitor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033547
InterPro:IPR033830

F

Seeded From UniProt

complete

enables

GO:0005518

collagen binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033547
InterPro:IPR033830

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000215

C

Seeded From UniProt

complete

involved_in

GO:0006986

response to unfolded protein

PMID:1309665[6]
PMID:10023073[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:7656593[9]
PMID:1309665[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0004867

serine-type endopeptidase inhibitor activity

PMID:1309665[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

Reactome:R-HSA-2089971
Reactome:R-HSA-2022073

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0096

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Christiansen, HE et al. (2010) Homozygosity for a missense mutation in SERPINH1, which encodes the collagen chaperone protein HSP47, results in severe recessive osteogenesis imperfecta. Am. J. Hum. Genet. 86 389-98 PubMed GONUTS page
  2. ↑ Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
  3. ↑ Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
  4. ↑ Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
  5. ↑ Fork, C et al. (2014) Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. Basic Res. Cardiol. 109 439 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Clarke, EP & Sanwal, BD (1992) Cloning of a human collagen-binding protein, and its homology with rat gp46, chick hsp47 and mouse J6 proteins. Biochim. Biophys. Acta 1129 246-8 PubMed GONUTS page
  7. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  8. ↑ Breuza, L et al. (2004) Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. J. Biol. Chem. 279 47242-53 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Ikegawa, S et al. (1995) Isolation, characterization and chromosomal assignment of human colligin-2 gene (CBP2). Cytogenet. Cell Genet. 71 182-6 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  11. ↑ Nagai, N et al. (1999) The human genome has only one functional hsp47 gene (CBP2) and a pseudogene (pshsp47). Gene 227 241-8 PubMed GONUTS page
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