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HUMAN:H2A1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | HIST1H2AM (synonyms: H2AFN) | |
| Protein Name(s) | Histone H2A type 1
H2A.1 Histone H2A/p | |
| External Links | ||
| UniProt | P0C0S8 | |
| EMBL | Z83742 Z83739 X83549 X57138 L19778 AY131987 AY131989 AY131991 AY131992 AY131993 Z98744 Z98744 Z98744 AL009179 AL021807 BC016677 BC069306 BC104199 BC104198 BC105129 BC112072 BC112254 BC112256 | |
| CCDS | CCDS4619.1 CCDS4626.1 CCDS4632.1 CCDS4634.1 CCDS4639.1 | |
| PIR | B56624 | |
| RefSeq | NP_003500.1 NP_003501.1 NP_003502.1 NP_003505.1 NP_066408.1 | |
| UniGene | Hs.134999 Hs.233568 Hs.51011 Hs.534035 Hs.734717 | |
| PDB | 4QYL | |
| PDBsum | 4QYL | |
| ProteinModelPortal | P0C0S8 | |
| SMR | P0C0S8 | |
| BioGrid | 113925 113926 113928 113932 114459 | |
| DIP | DIP-39638N | |
| IntAct | P0C0S8 | |
| MINT | MINT-1519720 | |
| STRING | 9606.ENSP00000330307 | |
| PhosphoSite | P0C0S8 | |
| DMDM | 83288406 | |
| MaxQB | P0C0S8 | |
| PRIDE | P0C0S8 | |
| DNASU | 8329 8330 8332 8969 | |
| Ensembl | ENST00000358739 ENST00000359193 ENST00000359611 ENST00000613174 ENST00000618958 | |
| GeneID | 8329 8330 8332 8336 8969 | |
| KEGG | hsa:8329 hsa:8330 hsa:8332 hsa:8336 hsa:8969 | |
| UCSC | uc003niw.3 | |
| CTD | 8329 8330 8332 8336 8969 | |
| GeneCards | GC06M027807 GC06M027944 GC06P027134 GC06P027780 GC06P027843 | |
| H-InvDB | HIX0200889 | |
| HGNC | HGNC:4737 HGNC:4725 HGNC:4726 HGNC:4730 HGNC:4735 | |
| MIM | 602787 602788 602793 602796 615012 | |
| neXtProt | NX_P0C0S8 | |
| PharmGKB | PA29114 | |
| GeneTree | ENSGT00760000118934 | |
| HOGENOM | HOG000234652 | |
| HOVERGEN | HBG009342 | |
| InParanoid | P0C0S8 | |
| KO | K11251 | |
| OMA | NSKSRSA | |
| OrthoDB | EOG7M0NTR | |
| PhylomeDB | P0C0S8 | |
| TreeFam | TF300137 | |
| Reactome | REACT_172610 REACT_228108 REACT_228222 | |
| ChiTaRS | HIST1H2AM | |
| GeneWiki | HIST1H2AG HIST1H2AI HIST1H2AK HIST1H2AL HIST1H2AM | |
| NextBio | 31190 | |
| PRO | PR:P0C0S8 | |
| Proteomes | UP000005640 | |
| Bgee | P0C0S8 | |
| CleanEx | HS_HIST1H2AG HS_HIST1H2AI HS_HIST1H2AK HS_HIST1H2AL HS_HIST1H2AM | |
| ExpressionAtlas | P0C0S8 | |
| Genevestigator | P0C0S8 | |
| GO | GO:0070062 GO:0000786 GO:0005634 GO:0003677 GO:0019899 | |
| Gene3D | 1.10.20.10 | |
| InterPro | IPR009072 IPR007125 IPR002119 | |
| Pfam | PF00125 | |
| PRINTS | PR00620 | |
| SMART | SM00414 | |
| SUPFAM | SSF47113 | |
| PROSITE | PS00046 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0016574 |
histone ubiquitination |
ECO:0000314 |
P |
Figure 6 shows RNF8 is required for H2AX ubiquitylation following DNA damage. |
complete | |||||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000639) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008150 |
biological_process |
ECO:0000307 |
no biological data found used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000019) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2448285 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
CGD:CAL0000179664 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:102688 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000786 |
nucleosome |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000786 |
nucleosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Huen, MS et al. (2007) RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell 131 901-14 PubMed GONUTS page
- ↑ Bonenfant, D et al. (2006) Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry. Mol. Cell Proteomics 5 541-52 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ 4.0 4.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
- ↑ Boyne, MT 2nd et al. (2006) Precise characterization of human histones in the H2A gene family by top down mass spectrometry. J. Proteome Res. 5 248-53 PubMed GONUTS page
- ↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
- ↑ Nicassio, F et al. (2007) Human USP3 is a chromatin modifier required for S phase progression and genome stability. Curr. Biol. 17 1972-7 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
