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User:Amendes

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CACAO Spring 2016

My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
unacceptableMOUSE:DCP22016-04-12 09:34:18 CDTGO:0071222 cellular response to lipopolysaccharide (P)PMID:27034373ECO:0000315 mutant phenotype evidence used in manual assertion

In Fig.3E the up regulation of the non coding RNA after LPS exposure is diminished in the Dcp2 knockout in the bone marrow derived mouse macrophages

challenge
unacceptableMOUSE:HNRPD2016-04-12 09:51:29 CDTGO:0071222 cellular response to lipopolysaccharide (P)PMID:27034373ECO:0000315 mutant phenotype evidence used in manual assertion

Fg. 4C An increased gene expression response to LPS when hnrnpd is knocked out.

challenge
acceptableMOUSE:HNRPD2016-04-12 10:08:20 CDTGO:0000790 nuclear chromatin (C)PMID:27034373ECO:0000314 direct assay evidence used in manual assertion

Fg.S7G Chip of hnrpd shows enrichment in chromatin.

challenge
unacceptableHUMAN:TERF22016-04-15 10:02:47 CDTPMID:26856421ECO:0000314 direct assay evidence used in manual assertion

Fg. 4d 4e: shows DNA binding

challenge
updatedbyinstructorHUMAN:CTSL22016-04-19 01:54:11 CDTGO:0005737 cytoplasm (C)PMID:26920047ECO:0000314 direct assay evidence used in manual assertion

Fg. 5C Immunostaining of hemintreated

cells revealed time-dependent accumulation of SCP4 in the cytoplasm.

challenge
acceptableHUMAN:CTSL22016-04-19 02:04:41 CDTGO:0008420 CTD phosphatase activity (F)PMID:26920047ECO:0000314 direct assay evidence used in manual assertion

Fg 1B. SCP4 functions as a

Ser5-preferential CTD phosphatase in cells.

challenge
unacceptableHUMAN:CTSL22016-04-19 02:12:24 CDTGO:0004647 phosphoserine phosphatase activity (F)PMID:26920047ECO:0000314 direct assay evidence used in manual assertion

Fg. 2C SCP4 can function as a Ser5-specific CTD phosphatase in cells.

challenge
acceptableHUMAN:CTSL22016-04-19 02:22:48 CDTGO:0000790 nuclear chromatin (C)PMID:26920047ECO:0000314 direct assay evidence used in manual assertion

Fg. 5B dynamic SCP4 relocation from the chromatin, out of the nucleus, and towards the cytoplasm.

challenge

acceptable:3
unacceptable:4
requires_changes:0
flagged:0

Annotations challenged by Amendes

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history

0 annotations fixed by Amendes

What do the icons mean in the status column?

assessment icons.jpg