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MOUSE:HNRPD

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Hnrnpd (synonyms: Auf1, Hnrpd)
Protein Name(s) Heterogeneous nuclear ribonucleoprotein D0

hnRNP D0 AU-rich element RNA-binding protein 1

External Links
UniProt Q60668
EMBL U11273
U11274
BC011172
BC049098
CCDS CCDS39180.1
CCDS39181.1
CCDS39182.1
CCDS51571.1
PIR I49069
I49070
RefSeq NP_001070733.1
NP_001070734.1
NP_001070735.1
NP_031542.2
XP_006534798.1
UniGene Mm.150231
ProteinModelPortal Q60668
SMR Q60668
BioGrid 198279
DIP DIP-31411N
IntAct Q60668
MINT MINT-1864708
STRING 10090.ENSMUSP00000132735
iPTMnet Q60668
PhosphoSite Q60668
SwissPalm Q60668
EPD Q60668
MaxQB Q60668
PaxDb Q60668
PRIDE Q60668
Ensembl ENSMUST00000019128
ENSMUST00000172361
GeneID 11991
KEGG mmu:11991
UCSC uc008ygt.2
uc008ygu.2
CTD 3184
MGI MGI:101947
eggNOG KOG0118
COG0724
GeneTree ENSGT00760000118873
HOGENOM HOG000234441
HOVERGEN HBG002295
InParanoid Q60668
KO K13044
OMA TFKDEEP
OrthoDB EOG715Q6V
PhylomeDB Q60668
TreeFam TF314808
Reactome R-MMU-450408
R-MMU-72163
R-MMU-72203
ChiTaRS Hnrnpd
NextBio 280159
PRO PR:Q60668
Proteomes UP000000589
Bgee Q60668
ExpressionAtlas Q60668
Genevisible Q60668
GO GO:0005829
GO:0070062
GO:0030529
GO:0005654
GO:0003680
GO:0003682
GO:0035925
GO:0000166
GO:0044822
GO:0003723
GO:0042162
GO:0061158
GO:0071230
GO:0071392
GO:0071732
GO:1904586
GO:0021549
GO:0097167
GO:1990828
GO:0001889
GO:0048255
GO:0045727
GO:0042752
GO:0043488
GO:0006355
GO:0051592
GO:0051602
GO:0014076
GO:1901355
GO:1904383
GO:0006351
Gene3D 3.30.70.330
InterPro IPR012956
IPR012677
IPR000504
Pfam PF08143
PF00076
SMART SM00360
SUPFAM SSF54928
PROSITE PS50102

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0071222

cellular response to lipopolysaccharide

PMID:27034373[1]

ECO:0000315

P

Fg. 4C An increased gene expression response to LPS when hnrnpd is knocked out.

complete
CACAO 11704

GO:0000790

nuclear chromatin

PMID:27034373[1]

ECO:0000314

C

Fg.S7G Chip of hnrpd shows enrichment in chromatin.

complete
CACAO 11705

involved_in

GO:1905663

positive regulation of telomerase RNA reverse transcriptase activity

PMID:22633954[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1904355

positive regulation of telomere capping

PMID:22633954[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032204

regulation of telomere maintenance

PMID:22633954[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097167

circadian regulation of translation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q14103

P

Seeded From UniProt

complete

involved_in

GO:0045727

positive regulation of translation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q14103

P

Seeded From UniProt

complete

involved_in

GO:0042752

regulation of circadian rhythm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q14103

P

Seeded From UniProt

complete

enables

GO:0042162

telomeric DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q14103

F

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q14103

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q14103

F

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:16452087[3]

ECO:0006042

cell fractionation evidence used in manual assertion

C

part_of:(UBERON:0000955)

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:16452087[3]

ECO:0001230

mass spectrometry evidence used in manual assertion

C

part_of:(UBERON:0000955)

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001215
FB:FBgn0004237
FB:FBgn0004838
MGI:MGI:1916394
PANTHER:PTN002689974
UniProtKB:P09651
UniProtKB:P19338
UniProtKB:P22626
UniProtKB:Q14103
UniProtKB:Q96EP5
UniProtKB:Q99729

C

Seeded From UniProt

complete

enables

GO:1990837

sequence-specific double-stranded DNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002545010
RGD:69255

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1330294
PANTHER:PTN002545010

F

Seeded From UniProt

complete

enables

GO:0035925

mRNA 3'-UTR AU-rich region binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002548379
RGD:620365

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004838
PANTHER:PTN002689978
UniProtKB:O14979
UniProtKB:Q14103
UniProtKB:Q96EP5
UniProtKB:Q99729

C

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002548379
RGD:620365

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104819
MGI:MGI:1330294
MGI:MGI:893588
MGI:MGI:97286
PANTHER:PTN002689974
RGD:1306751
RGD:1310403
RGD:1310906
RGD:3153
RGD:69234
SGD:S000003391
SGD:S000005483
TAIR:locus:2019622
TAIR:locus:2076096
TAIR:locus:2079874
TAIR:locus:2083810
TAIR:locus:2122009
TAIR:locus:2159401
TAIR:locus:2179939
UniProtKB:P19338
UniProtKB:P22626
UniProtKB:P38159
UniProtKB:P62995
UniProtKB:Q03250
UniProtKB:Q13148
UniProtKB:Q14103
UniProtKB:Q9SVM8

F

Seeded From UniProt

complete

enables

GO:0003680

AT DNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002548379
RGD:620365

F

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q14103

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904586

cellular response to putrescine

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904383

response to sodium phosphate

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901355

response to rapamycin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097167

circadian regulation of translation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q14103

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071732

cellular response to nitric oxide

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061158

3'-UTR-mediated mRNA destabilization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051592

response to calcium ion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048255

mRNA stabilization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045727

positive regulation of translation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q14103

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043488

regulation of mRNA stability

PMID:14976220[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042752

regulation of circadian rhythm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q14103

P

Seeded From UniProt

complete

enables

GO:0042162

telomeric DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q14103

F

Seeded From UniProt

complete

enables

GO:0035925

mRNA 3'-UTR AU-rich region binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010629

negative regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q14103

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

C

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q14103

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

F

Seeded From UniProt

complete

enables

GO:0003680

AT DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620365

F

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14103
ensembl:ENSP00000313199

C

Seeded From UniProt

complete

involved_in

GO:0097167

circadian regulation of translation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14103
ensembl:ENSP00000313199

P

Seeded From UniProt

complete

involved_in

GO:0045727

positive regulation of translation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14103
ensembl:ENSP00000313199

P

Seeded From UniProt

complete

involved_in

GO:0042752

regulation of circadian rhythm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14103
ensembl:ENSP00000313199

P

Seeded From UniProt

complete

enables

GO:0042162

telomeric DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14103
ensembl:ENSP00000313199

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14103
ensembl:ENSP00000313199

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q14103
ensembl:ENSP00000313199

F

Seeded From UniProt

complete

involved_in

GO:1990828

hepatocyte dedifferentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

involved_in

GO:1904586

cellular response to putrescine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

involved_in

GO:1904383

response to sodium phosphate

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

involved_in

GO:1901355

response to rapamycin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

involved_in

GO:0071732

cellular response to nitric oxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

involved_in

GO:0071392

cellular response to estradiol stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

involved_in

GO:0071230

cellular response to amino acid stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

involved_in

GO:0061158

3'-UTR-mediated mRNA destabilization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

involved_in

GO:0051602

response to electrical stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

involved_in

GO:0051592

response to calcium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

involved_in

GO:0048255

mRNA stabilization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

F

Seeded From UniProt

complete

enables

GO:0035925

mRNA 3'-UTR AU-rich region binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

F

Seeded From UniProt

complete

involved_in

GO:0032355

response to estradiol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

involved_in

GO:0021549

cerebellum development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

F

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

C

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

F

Seeded From UniProt

complete

enables

GO:0003680

AT DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

F

Seeded From UniProt

complete

involved_in

GO:0001889

liver development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JJ54
ensembl:ENSRNOP00000046491

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A024RDF3
ensembl:ENSP00000313199

C

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000504
InterPro:IPR035979

F

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:22633954[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_transcription_of:(ENSEMBL:ENSMUSG00000021611)

Seeded From UniProt

complete

involved_in

GO:0042789

mRNA transcription by RNA polymerase II

PMID:22633954[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_direct_input:(ENSEMBL:ENSMUSG00000021611)

Seeded From UniProt

complete

involved_in

GO:0042789

mRNA transcription by RNA polymerase II

PMID:22633954[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_direct_input:(ENSEMBL:ENSMUSG00000021611)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:22633954[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_transcription_of:(ENSEMBL:ENSMUSG00000021611)

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Castellanos-Rubio, A et al. (2016) A long noncoding RNA associated with susceptibility to celiac disease. Science 352 91-5 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Pont, AR et al. (2012) mRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcription. Mol. Cell 47 5-15 PubMed GONUTS page
  3. 3.0 3.1 Trinidad, JC et al. (2006) Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol. Cell Proteomics 5 914-22 PubMed GONUTS page
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