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PMID:27034373
| Citation |
Castellanos-Rubio, A, Fernandez-Jimenez, N, Kratchmarov, R, Luo, X, Bhagat, G, Green, PH, Schneider, R, Kiledjian, M, Bilbao, JR and Ghosh, S (2016) A long noncoding RNA associated with susceptibility to celiac disease. Science 352:91-5 |
|---|---|
| Abstract |
Recent studies have implicated long noncoding RNAs (lncRNAs) as regulators of many important biological processes. Here we report on the identification and characterization of a lncRNA, lnc13, that harbors a celiac disease-associated haplotype block and represses expression of certain inflammatory genes under homeostatic conditions. Lnc13 regulates gene expression by binding to hnRNPD, a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Upon stimulation, lnc13 levels are reduced, thereby allowing increased expression of the repressed genes. Lnc13 levels are significantly decreased in small intestinal biopsy samples from patients with celiac disease, which suggests that down-regulation of lnc13 may contribute to the inflammation seen in this disease. Furthermore, the lnc13 disease-associated variant binds hnRNPD less efficiently than its wild-type counterpart, thus helping to explain how these single-nucleotide polymorphisms contribute to celiac disease. |
| Links |
PubMed Online version:10.1126/science.aad0467 |
| Keywords |
Animals; Base Sequence; Celiac Disease/genetics; Celiac Disease/pathology; Down-Regulation; Gene Expression Regulation; Genetic Predisposition to Disease; Haplotypes; Heterogeneous-Nuclear Ribonucleoproteins/genetics; Humans; Inflammation/genetics; Mice; Molecular Sequence Data; Polymorphism, Single Nucleotide; RNA, Long Noncoding/genetics |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0071222: cellular response to lipopolysaccharide |
ECO:0000315: |
P |
In Fig.3E the up regulation of the non coding RNA after LPS exposure is diminished in the Dcp2 knockout in the bone marrow derived mouse macrophages |
complete | ||||
| GO:0071222: cellular response to lipopolysaccharide |
ECO:0000315: |
P |
Fg. 4C An increased gene expression response to LPS when hnrnpd is knocked out. |
complete | ||||
| GO:0000790: nuclear chromatin |
ECO:0000314: |
C |
Fg.S7G Chip of hnrpd shows enrichment in chromatin. |
complete | ||||
Notes
See also
References
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