MOUSE:DCP2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Dcp2
Protein Name(s)	m7GpppN-mRNA hydrolase mRNA-decapping enzyme 2
External Links
UniProt	Q9CYC6
EMBL	AK017809 AK166560
CCDS	CCDS50275.1
RefSeq	NP_081766.1
UniGene	Mm.87629
ProteinModelPortal	Q9CYC6
SMR	Q9CYC6
STRING	10090.ENSMUSP00000025350
iPTMnet	Q9CYC6
PhosphoSite	Q9CYC6
EPD	Q9CYC6
MaxQB	Q9CYC6
PaxDb	Q9CYC6
PRIDE	Q9CYC6
Ensembl	ENSMUST00000025350
GeneID	70640
KEGG	mmu:70640
UCSC	uc008eux.2
CTD	167227
MGI	MGI:1917890
eggNOG	KOG2937 COG0494
GeneTree	ENSGT00390000018878
HOGENOM	HOG000005974
HOVERGEN	HBG051321
InParanoid	Q9CYC6
KO	K12613
OMA	KKRTNGV
OrthoDB	EOG7XM2XP
TreeFam	TF314180
BRENDA	3.6.1.62
Reactome	R-MMU-430039 R-MMU-450385 R-MMU-450604
NextBio	332021
PRO	PR:Q9CYC6
Proteomes	UP000000589
Bgee	Q9CYC6
CleanEx	MM_DCP2
Genevisible	Q9CYC6
GO	GO:0030054 GO:0000932 GO:0043231 GO:0005654 GO:0016442 GO:0050072 GO:0030145 GO:0003723 GO:0000290 GO:0071044 GO:0006402 GO:0000184
Gene3D	3.90.79.10
InterPro	IPR007722 IPR020084 IPR000086 IPR015797
Pfam	PF05026 PF00293
SUPFAM	SSF55811
PROSITE	PS51462 PS00893

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0071222	cellular response to lipopolysaccharide	PMID:27034373^[1]	ECO:0000315			P	In Fig.3E the up regulation of the non coding RNA after LPS exposure is diminished in the Dcp2 knockout in the bone marrow derived mouse macrophages	complete CACAO 11703
involved_in	GO:0043488	regulation of mRNA stability	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IU60	P	Seeded From UniProt	complete
involved_in	GO:0006402	mRNA catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IU60	P	Seeded From UniProt	complete
involved_in	GO:0071044	histone mRNA catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IU60	P	Seeded From UniProt	complete
enables	GO:0050072	m7G(5')pppN diphosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IU60	F	Seeded From UniProt	complete
involved_in	GO:0006402	mRNA catabolic process	PMID:21070968^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0050072	m7G(5')pppN diphosphatase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036534 PANTHER:PTN000561807 PomBase:SPAC19A8.12 SGD:S000005062 TAIR:locus:2173174 UniProtKB:Q8IU60 WB:WBGene00003582	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036534 PANTHER:PTN000561806 PomBase:SPAC19A8.12 SGD:S000005062 TAIR:locus:2173174	C	Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036534 PANTHER:PTN000561808 PomBase:SPAC19A8.12 SGD:S000005062 UniProtKB:Q8IU60 WB:WBGene00003582	C	Seeded From UniProt	complete
involved_in	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036534 PANTHER:PTN000561807 PomBase:SPAC19A8.12 SGD:S000005062 WB:WBGene00003582	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904872	regulation of telomerase RNA localization to Cajal body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU60	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071044	histone mRNA catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU60	P	Seeded From UniProt	complete
enables	GO:0050072	m7G(5')pppN diphosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU60	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043488	regulation of mRNA stability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU60	P	Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU60	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032211	negative regulation of telomere maintenance via telomerase	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU60	P	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU60	C	Seeded From UniProt	complete
part_of	GO:0016442	RISC complex	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU60	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006402	mRNA catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU60	P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU60	C	Seeded From UniProt	complete
enables	GO:0004534	5'-3' exoribonuclease activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU60	F	Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU60	C	Seeded From UniProt	complete
involved_in	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004534	P	Seeded From UniProt	complete
involved_in	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004534	P	Seeded From UniProt	complete
involved_in	GO:1904872	regulation of telomerase RNA localization to Cajal body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU60 ensembl:ENSP00000373715	P	Seeded From UniProt	complete
involved_in	GO:0071044	histone mRNA catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU60 ensembl:ENSP00000373715	P	Seeded From UniProt	complete
enables	GO:0050072	m7G(5')pppN diphosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU60 ensembl:ENSP00000373715	F	Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU60 ensembl:ENSP00000373715	P	Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU60 ensembl:ENSP00000373715	C	Seeded From UniProt	complete
involved_in	GO:0032211	negative regulation of telomere maintenance via telomerase	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU60 ensembl:ENSP00000373715	P	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU60 ensembl:ENSP00000373715	C	Seeded From UniProt	complete
part_of	GO:0016442	RISC complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU60 ensembl:ENSP00000373715	C	Seeded From UniProt	complete
involved_in	GO:0006402	mRNA catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU60 ensembl:ENSP00000373715	P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU60 ensembl:ENSP00000373715	C	Seeded From UniProt	complete
enables	GO:0004534	5'-3' exoribonuclease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU60 ensembl:ENSP00000373715	F	Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU60 ensembl:ENSP00000373715	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007722 InterPro:IPR036189	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000086 InterPro:IPR007722 InterPro:IPR015797 InterPro:IPR020084 InterPro:IPR036189	F	Seeded From UniProt	complete
enables	GO:0030145	manganese ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007722 InterPro:IPR036189	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0866	P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0230	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Castellanos-Rubio, A et al. (2016) A long noncoding RNA associated with susceptibility to celiac disease. Science 352 91-5 PubMed GONUTS page
↑ Song, MG et al. (2010) Multiple mRNA decapping enzymes in mammalian cells. Mol. Cell 40 423-32 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:27034373-1] Castellanos-Rubio, A et al. (2016) A long noncoding RNA associated with susceptibility to celiac disease. Science 352 91-5 PubMed GONUTS page

[PMID:21070968-2] Song, MG et al. (2010) Multiple mRNA decapping enzymes in mammalian cells. Mol. Cell 40 423-32 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:DCP2

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