Cacao

Since the protein itself is actually inhibiting the respiratory process by inhibiting the activity of complex III and IV, a GO term that specifies the negative regulation of the cellular respiration process (or ETC or Mitochondrial respiratory chain). Therefore, the GO term "Negative Regulation of Cellular Respiration" (GO:1901856) should be used.

There is an error in the GO term. The selected GO term doesn't have the specificity needed but Figure 3 shows how Tat inhibits mitochondrial complexes III and IV and compares it against complex I and II activity. The correct GO term should be GO:0097034 because after treating Tat to each complex it had a surprising effect of decreasing complex IV activity showing that it has a concentration-dependent inhibition function

I believe the error is with the GO Term. The given go term lacks the specificity and does not show the detail of inhibition specifically of complex III, as shown in the data. The Go term GO:0005750 should be used instead.

The problem that I see that needs to be fixed is the GO Term; it isn't specific enough. Figure 3 in the paper clearly states that TAT inhibits both the mitochondrial respiratory chain complexes III and IV, GO:0005750 and GO:0005751 respectively. They could do two different annotations using the two different GO Terms based on the same figure.