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RAT:UCN1
Contents
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:2000987 |
positive regulation of behavioral fear response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000252 |
negative regulation of feeding behavior |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1901215 |
negative regulation of neuron death |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097755 |
positive regulation of blood vessel diameter |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090280 |
positive regulation of calcium ion import |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090280 |
positive regulation of calcium ion import |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060548 |
negative regulation of cell death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060547 |
negative regulation of necrotic cell death |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060455 |
negative regulation of gastric acid secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060452 |
positive regulation of cardiac muscle contraction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051966 |
regulation of synaptic transmission, glutamatergic |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051461 |
positive regulation of corticotropin secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051431 |
corticotropin-releasing hormone receptor 2 binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:70547 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0051430 |
corticotropin-releasing hormone receptor 1 binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:61276 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051384 |
response to glucocorticoid |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048265 |
response to pain |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046888 |
negative regulation of hormone secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046811 |
histone deacetylase inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045792 |
negative regulation of cell size |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045776 |
negative regulation of blood pressure |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045740 |
positive regulation of DNA replication |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045727 |
positive regulation of translation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043950 |
positive regulation of cAMP-mediated signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0043679 |
axon terminus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0043204 |
perikaryon |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0043196 |
varicosity |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043117 |
positive regulation of vascular permeability |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042756 |
drinking behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035483 |
gastric emptying |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035176 |
social behavior |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034199 |
activation of protein kinase A activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032967 |
positive regulation of collagen biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032755 |
positive regulation of interleukin-6 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032355 |
response to estradiol |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032099 |
negative regulation of appetite |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031175 |
neuron projection development |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0030425 |
dendrite |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030424 |
axon |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030307 |
positive regulation of cell growth |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030157 |
pancreatic juice secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009060 |
aerobic respiration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008306 |
associative learning |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007631 |
feeding behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007611 |
learning or memory |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007565 |
female pregnancy |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007218 |
neuropeptide signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006979 |
response to oxidative stress |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0001664 |
G protein-coupled receptor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000252 |
negative regulation of feeding behavior |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000385780 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070093 |
negative regulation of glucagon secretion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001030516 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051464 |
positive regulation of cortisol secretion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001030516 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032811 |
negative regulation of epinephrine secretion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001030516 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0017045 |
corticotropin-releasing hormone activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001030516 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001030516 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0017045 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031064 |
negative regulation of histone deacetylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046811 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051461 |
positive regulation of corticotropin secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55089 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P81615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010996 |
response to auditory stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P81615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001964 |
startle response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P81615 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0005179 |
hormone activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005179 |
hormone activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007605 |
sensory perception of sound |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Radulovic, J et al. (1999) Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. J. Neurosci. 19 5016-25 PubMed GONUTS page
- ↑ 2.0 2.1 Currie, PJ et al. (2001) Hypothalamic paraventricular nucleus injections of urocortin alter food intake and respiratory quotient. Brain Res. 916 222-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Pedersen, WA et al. (2002) Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I. J. Neurosci. 22 404-12 PubMed GONUTS page
- ↑ Miki, I et al. (2004) Role of corticotropin-releasing factor receptor type 2 beta in urocortin-induced vasodilation of rat aortas. J. Pharmacol. Sci. 96 170-6 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Calderón-Sanchez, E et al. (2009) Urocortin induces positive inotropic effect in rat heart. Cardiovasc. Res. 83 717-25 PubMed GONUTS page
- ↑ Kageyama, K et al. (2006) Modulation of Ca2+ influx by corticotropin-releasing factor (CRF) family of peptides via CRF receptors in rat pancreatic beta-cells. Peptides 27 1814-9 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Huang, HY et al. (2011) Urocortin modulates dopaminergic neuronal survival via inhibition of glycogen synthase kinase-3β and histone deacetylase. Neurobiol. Aging 32 1662-77 PubMed GONUTS page
- ↑ Takatani-Nakase, T & Takahashi, K (2010) Cardioprotective activity of urocortin by preventing caspase-independent, non-apoptotic death in cultured neonatal rat cardiomyocytes exposed to ischemia. Biochem. Biophys. Res. Commun. 402 216-21 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Yakabi, K et al. (2011) Urocortin 1 reduces food intake and ghrelin secretion via CRF(2) receptors. Am. J. Physiol. Endocrinol. Metab. 301 E72-82 PubMed GONUTS page
- ↑ Liu, J et al. (2004) Corticotropin-releasing factor and Urocortin I modulate excitatory glutamatergic synaptic transmission. J. Neurosci. 24 4020-9 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Vaughan, J et al. (1995) Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 378 287-92 PubMed GONUTS page
- ↑ Hoare, SR et al. (2004) Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists. Biochemistry 43 3996-4011 PubMed GONUTS page
- ↑ 13.0 13.1 Wu, Y et al. (2006) Enhanced expression of urocortin in lung tissues of rats with allergic asthma. Biochem. Biophys. Res. Commun. 341 532-40 PubMed GONUTS page
- ↑ Rouwette, T et al. (2011) Differential responses of corticotropin-releasing factor and urocortin 1 to acute pain stress in the rat brain. Neuroscience 183 15-24 PubMed GONUTS page
- ↑ Abdelrahman, AM et al. (2005) Analysis of the mechanism of the vasodepressor effect of urocortin in anesthetized rats. Pharmacology 73 175-9 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 Nishikimi, T et al. (2000) Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart. Am. J. Physiol. Heart Circ. Physiol. 279 H3031-9 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 17.3 Swinny, JD et al. (2002) The localisation of urocortin in the adult rat cerebellum: a light and electron microscopic study. Neuroscience 114 891-903 PubMed GONUTS page
- ↑ Bittencourt, JC et al. (1999) Urocortin expression in rat brain: evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors. J. Comp. Neurol. 415 285-312 PubMed GONUTS page
- ↑ Henry, BA et al. (2005) Distribution of corticotropin-releasing factor binding protein-immunoreactivity in the rat hypothalamus: association with corticotropin-releasing factor-, urocortin 1- and vimentin-immunoreactive fibres. J. Neuroendocrinol. 17 135-44 PubMed GONUTS page
- ↑ Cureton, EL et al. (2009) Local secretion of urocortin 1 promotes microvascular permeability during lipopolysaccharide-induced inflammation. Endocrinology 150 5428-37 PubMed GONUTS page
- ↑ 21.0 21.1 Chanalaris, A et al. (2003) Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes. J. Mol. Cell. Cardiol. 35 1295-305 PubMed GONUTS page
- ↑ 22.0 22.1 Ohata, H et al. (2000) Urocortin in the ventromedial hypothalamic nucleus acts as an inhibitor of feeding behavior in rats. Brain Res. 861 1-7 PubMed GONUTS page
- ↑ Spiga, F et al. (2006) Injections of urocortin 1 into the basolateral amygdala induce anxiety-like behavior and c-Fos expression in brainstem serotonergic neurons. Neuroscience 138 1265-76 PubMed GONUTS page
- ↑ Kageyama, K & Suda, T (2003) Urocortin-related peptides increase interleukin-6 output via cyclic adenosine 5'-monophosphate-dependent pathways in A7r5 aortic smooth muscle cells. Endocrinology 144 2234-41 PubMed GONUTS page
- ↑ Haeger, P et al. (2006) Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene. J. Neurosci. 26 4908-16 PubMed GONUTS page
- ↑ Swinny, JD et al. (2004) Corticotropin-releasing factor and urocortin differentially modulate rat Purkinje cell dendritic outgrowth and differentiation in vitro. Eur. J. Neurosci. 19 1749-58 PubMed GONUTS page
- ↑ Chanalaris, A et al. (2005) Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway. Biochem. Biophys. Res. Commun. 328 442-8 PubMed GONUTS page
- ↑ Guzman, EA et al. (2003) Stimulation of rat pancreatic exocrine secretion by urocortin and corticotropin releasing factor. Peptides 24 727-34 PubMed GONUTS page
- ↑ Lawrence, KM et al. (2003) Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium-insensitive phospholipase A2 gene expression. FASEB J. 17 2313-5 PubMed GONUTS page
- ↑ Zorrilla, EP et al. (2002) Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors. Brain Res. 952 200-10 PubMed GONUTS page
- ↑ Fatima, A et al. (2007) Reduced urocortin 1 immunoreactivity in the non-preganglionic Edinger-Westphal nucleus during late pregnancy in rats. Regul. Pept. 143 34-8 PubMed GONUTS page
- ↑ 32.0 32.1 32.2 32.3 32.4 32.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
a
c
e
n
- GO:2000252 ! negative regulation of feeding behavior
- GO:0032811 ! negative regulation of epinephrine secretion
- GO:0032099 ! negative regulation of appetite
- GO:0010629 ! negative regulation of gene expression
- GO:0046888 ! negative regulation of hormone secretion
- GO:0045776 ! negative regulation of blood pressure
- GO:0060455 ! negative regulation of gastric acid secretion
- GO:0070093 ! negative regulation of glucagon secretion
- GO:0043066 ! negative regulation of apoptotic process
- GO:0045792 ! negative regulation of cell size
- GO:0043025 ! neuronal cell body
- GO:0031175 ! neuron projection development
- GO:0007218 ! neuropeptide signaling pathway
o
- GO:0060547 ! obsolete negative regulation of necrotic cell death
- GO:0060548 ! obsolete negative regulation of cell death
- GO:1901215 ! obsolete negative regulation of neuron death
- GO:0031064 ! obsolete negative regulation of histone deacetylation
- GO:0097755 ! obsolete positive regulation of blood vessel diameter
p
- GO:0030157 ! pancreatic juice secretion
- GO:0043204 ! perikaryon
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0051464 ! positive regulation of cortisol secretion
- GO:2000987 ! positive regulation of behavioral fear response
- GO:0001934 ! positive regulation of protein phosphorylation
- GO:0043950 ! positive regulation of cAMP-mediated signaling
- GO:0010628 ! positive regulation of gene expression
- GO:0030307 ! positive regulation of cell growth
- GO:0090280 ! positive regulation of calcium ion import
- GO:0032755 ! positive regulation of interleukin-6 production
- GO:0032967 ! positive regulation of collagen biosynthetic process
- GO:0060452 ! positive regulation of cardiac muscle contraction
- GO:0051461 ! positive regulation of corticotropin secretion
- GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
- GO:0045740 ! positive regulation of DNA replication
- GO:0045727 ! positive regulation of translation
- GO:0043117 ! positive regulation of vascular permeability
r
- Rattus
- Rattus norvegicus
- GO:0010469 ! regulation of signaling receptor activity
- GO:0051966 ! regulation of synaptic transmission, glutamatergic
- GO:0006979 ! response to oxidative stress
- GO:0048265 ! response to pain
- GO:0051384 ! response to glucocorticoid
- GO:0010996 ! response to auditory stimulus
- GO:0032355 ! response to estradiol
- Rodentia
s