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RAT:UCN1

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Ucn
Protein Name(s) Urocortin

Corticotensin

External Links
UniProt P55090
EMBL U33935
AF093623
PIR S60262
RefSeq NP_062023.1
UniGene Rn.10190
ProteinModelPortal P55090
SMR P55090
BioGrid 247834
IntAct P55090
STRING 10116.ENSRNOP00000008037
PRIDE P55090
Ensembl ENSRNOT00000008037
GeneID 29151
KEGG rno:29151
CTD 7349
RGD 3929
eggNOG NOG46022
GeneTree ENSGT00510000049284
HOGENOM HOG000121779
HOVERGEN HBG036241
InParanoid P55090
OMA LRWSPGA
OrthoDB EOG73JKZD
PhylomeDB P55090
TreeFam TF332956
NextBio 608159
PRO PR:P55090
Proteomes UP000002494
Genevestigator P55090
GO GO:0030424
GO:0043679
GO:0030425
GO:0005576
GO:0043025
GO:0043204
GO:0043196
GO:0051430
GO:0051431
GO:0001664
GO:0046811
GO:0034199
GO:0009060
GO:0008306
GO:0042756
GO:0007631
GO:0007565
GO:0035483
GO:0006954
GO:0007611
GO:0043066
GO:0032099
GO:0045776
GO:0060548
GO:0045792
GO:2000252
GO:0060455
GO:0010629
GO:0031064
GO:0046888
GO:0060547
GO:1901215
GO:0031175
GO:0007218
GO:0030157
GO:2000987
GO:0090280
GO:0030819
GO:0060452
GO:0030307
GO:0032967
GO:0051461
GO:0045740
GO:0010628
GO:0032755
GO:0033138
GO:0001934
GO:0045727
GO:0043117
GO:0045909
GO:0051966
GO:0032355
GO:0051384
GO:0006979
GO:0048265
GO:0035176
InterPro IPR018446
IPR000187
IPR003620
PANTHER PTHR15035
Pfam PF00473
PRINTS PR01612
SMART SM00039
PROSITE PS00511

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:2000987

positive regulation of behavioral fear response

PMID:10366634[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000252

negative regulation of feeding behavior

PMID:11597609[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901215

negative regulation of neuron death

PMID:11784785[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097755

positive regulation of blood vessel diameter

PMID:15467262[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090280

positive regulation of calcium ion import

PMID:19460778[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090280

positive regulation of calcium ion import

PMID:16513211[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060548

negative regulation of cell death

PMID:19875195[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060547

negative regulation of necrotic cell death

PMID:20933497[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060455

negative regulation of gastric acid secretion

PMID:21540451[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060452

positive regulation of cardiac muscle contraction

PMID:19460778[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051966

regulation of synaptic transmission, glutamatergic

PMID:15102917[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051461

positive regulation of corticotropin secretion

PMID:7477349[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051431

corticotropin-releasing hormone receptor 2 binding

PMID:7477349[11]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:70547

F

Seeded From UniProt

complete

enables

GO:0051430

corticotropin-releasing hormone receptor 1 binding

PMID:15049707[12]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:61276

F

Seeded From UniProt

complete

involved_in

GO:0051384

response to glucocorticoid

PMID:16427607[13]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048265

response to pain

PMID:21463663[14]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046888

negative regulation of hormone secretion

PMID:21540451[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046811

histone deacetylase inhibitor activity

PMID:19875195[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045792

negative regulation of cell size

PMID:19460778[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045776

negative regulation of blood pressure

PMID:15604589[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045740

positive regulation of DNA replication

PMID:11087261[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045727

positive regulation of translation

PMID:11087261[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043950

positive regulation of cAMP-mediated signaling

PMID:7477349[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043679

axon terminus

PMID:12379245[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

PMID:10553117[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043196

varicosity

PMID:15796765[19]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043117

positive regulation of vascular permeability

PMID:19819946[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:14519439[21]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

PMID:12379245[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042756

drinking behavior

PMID:10751559[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035483

gastric emptying

PMID:21540451[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035176

social behavior

PMID:16488545[23]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034199

activation of protein kinase A activity

PMID:19460778[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

PMID:19875195[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032967

positive regulation of collagen biosynthetic process

PMID:11087261[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032755

positive regulation of interleukin-6 production

PMID:12746280[24]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032355

response to estradiol

PMID:16672665[25]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032099

negative regulation of appetite

PMID:21540451[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031175

neuron projection development

PMID:15078549[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

PMID:12379245[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:12379245[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030307

positive regulation of cell growth

PMID:15694367[27]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030157

pancreatic juice secretion

PMID:12895659[28]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:21540451[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:14563694[29]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:21540451[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009060

aerobic respiration

PMID:11597609[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008306

associative learning

PMID:10366634[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007631

feeding behavior

PMID:10751559[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007611

learning or memory

PMID:12376180[30]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

PMID:17391780[31]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

PMID:11784785[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

PMID:11784785[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:16427607[13]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

PMID:14519439[21]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001664

G protein-coupled receptor binding

PMID:11784785[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:2000252

negative regulation of feeding behavior

PMID:21873635[32]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000385780
RGD:3929

P

Seeded From UniProt

complete

involved_in

GO:0070093

negative regulation of glucagon secretion

PMID:21873635[32]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001030516
RGD:620505

P

Seeded From UniProt

complete

involved_in

GO:0051464

positive regulation of cortisol secretion

PMID:21873635[32]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001030516
UniProtKB:P06850

P

Seeded From UniProt

complete

involved_in

GO:0032811

negative regulation of epinephrine secretion

PMID:21873635[32]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001030516
RGD:620505

P

Seeded From UniProt

complete

enables

GO:0017045

corticotropin-releasing hormone activity

PMID:21873635[32]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001030516
UniProtKB:Q703P0

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[32]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001030516
RGD:620505
UniProtKB:P06850

C

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0017045

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0031064

negative regulation of histone deacetylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046811

P

Seeded From UniProt

complete

involved_in

GO:0051461

positive regulation of corticotropin secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55089
ensembl:ENSP00000296099

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P81615
ensembl:ENSMUSP00000035321

P

Seeded From UniProt

complete

involved_in

GO:0010996

response to auditory stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P81615
ensembl:ENSMUSP00000035321

P

Seeded From UniProt

complete

involved_in

GO:0001964

startle response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P81615
ensembl:ENSMUSP00000035321

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000187
InterPro:IPR003620

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000187
InterPro:IPR003620

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1009

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Radulovic, J et al. (1999) Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. J. Neurosci. 19 5016-25 PubMed GONUTS page
  2. 2.0 2.1 Currie, PJ et al. (2001) Hypothalamic paraventricular nucleus injections of urocortin alter food intake and respiratory quotient. Brain Res. 916 222-8 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Pedersen, WA et al. (2002) Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I. J. Neurosci. 22 404-12 PubMed GONUTS page
  4. Miki, I et al. (2004) Role of corticotropin-releasing factor receptor type 2 beta in urocortin-induced vasodilation of rat aortas. J. Pharmacol. Sci. 96 170-6 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Calderón-Sanchez, E et al. (2009) Urocortin induces positive inotropic effect in rat heart. Cardiovasc. Res. 83 717-25 PubMed GONUTS page
  6. Kageyama, K et al. (2006) Modulation of Ca2+ influx by corticotropin-releasing factor (CRF) family of peptides via CRF receptors in rat pancreatic beta-cells. Peptides 27 1814-9 PubMed GONUTS page
  7. 7.0 7.1 7.2 Huang, HY et al. (2011) Urocortin modulates dopaminergic neuronal survival via inhibition of glycogen synthase kinase-3β and histone deacetylase. Neurobiol. Aging 32 1662-77 PubMed GONUTS page
  8. Takatani-Nakase, T & Takahashi, K (2010) Cardioprotective activity of urocortin by preventing caspase-independent, non-apoptotic death in cultured neonatal rat cardiomyocytes exposed to ischemia. Biochem. Biophys. Res. Commun. 402 216-21 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 9.5 Yakabi, K et al. (2011) Urocortin 1 reduces food intake and ghrelin secretion via CRF(2) receptors. Am. J. Physiol. Endocrinol. Metab. 301 E72-82 PubMed GONUTS page
  10. Liu, J et al. (2004) Corticotropin-releasing factor and Urocortin I modulate excitatory glutamatergic synaptic transmission. J. Neurosci. 24 4020-9 PubMed GONUTS page
  11. 11.0 11.1 11.2 Vaughan, J et al. (1995) Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 378 287-92 PubMed GONUTS page
  12. Hoare, SR et al. (2004) Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists. Biochemistry 43 3996-4011 PubMed GONUTS page
  13. 13.0 13.1 Wu, Y et al. (2006) Enhanced expression of urocortin in lung tissues of rats with allergic asthma. Biochem. Biophys. Res. Commun. 341 532-40 PubMed GONUTS page
  14. Rouwette, T et al. (2011) Differential responses of corticotropin-releasing factor and urocortin 1 to acute pain stress in the rat brain. Neuroscience 183 15-24 PubMed GONUTS page
  15. Abdelrahman, AM et al. (2005) Analysis of the mechanism of the vasodepressor effect of urocortin in anesthetized rats. Pharmacology 73 175-9 PubMed GONUTS page
  16. 16.0 16.1 16.2 Nishikimi, T et al. (2000) Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart. Am. J. Physiol. Heart Circ. Physiol. 279 H3031-9 PubMed GONUTS page
  17. 17.0 17.1 17.2 17.3 Swinny, JD et al. (2002) The localisation of urocortin in the adult rat cerebellum: a light and electron microscopic study. Neuroscience 114 891-903 PubMed GONUTS page
  18. Bittencourt, JC et al. (1999) Urocortin expression in rat brain: evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors. J. Comp. Neurol. 415 285-312 PubMed GONUTS page
  19. Henry, BA et al. (2005) Distribution of corticotropin-releasing factor binding protein-immunoreactivity in the rat hypothalamus: association with corticotropin-releasing factor-, urocortin 1- and vimentin-immunoreactive fibres. J. Neuroendocrinol. 17 135-44 PubMed GONUTS page
  20. Cureton, EL et al. (2009) Local secretion of urocortin 1 promotes microvascular permeability during lipopolysaccharide-induced inflammation. Endocrinology 150 5428-37 PubMed GONUTS page
  21. 21.0 21.1 Chanalaris, A et al. (2003) Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes. J. Mol. Cell. Cardiol. 35 1295-305 PubMed GONUTS page
  22. 22.0 22.1 Ohata, H et al. (2000) Urocortin in the ventromedial hypothalamic nucleus acts as an inhibitor of feeding behavior in rats. Brain Res. 861 1-7 PubMed GONUTS page
  23. Spiga, F et al. (2006) Injections of urocortin 1 into the basolateral amygdala induce anxiety-like behavior and c-Fos expression in brainstem serotonergic neurons. Neuroscience 138 1265-76 PubMed GONUTS page
  24. Kageyama, K & Suda, T (2003) Urocortin-related peptides increase interleukin-6 output via cyclic adenosine 5'-monophosphate-dependent pathways in A7r5 aortic smooth muscle cells. Endocrinology 144 2234-41 PubMed GONUTS page
  25. Haeger, P et al. (2006) Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene. J. Neurosci. 26 4908-16 PubMed GONUTS page
  26. Swinny, JD et al. (2004) Corticotropin-releasing factor and urocortin differentially modulate rat Purkinje cell dendritic outgrowth and differentiation in vitro. Eur. J. Neurosci. 19 1749-58 PubMed GONUTS page
  27. Chanalaris, A et al. (2005) Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway. Biochem. Biophys. Res. Commun. 328 442-8 PubMed GONUTS page
  28. Guzman, EA et al. (2003) Stimulation of rat pancreatic exocrine secretion by urocortin and corticotropin releasing factor. Peptides 24 727-34 PubMed GONUTS page
  29. Lawrence, KM et al. (2003) Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium-insensitive phospholipase A2 gene expression. FASEB J. 17 2313-5 PubMed GONUTS page
  30. Zorrilla, EP et al. (2002) Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors. Brain Res. 952 200-10 PubMed GONUTS page
  31. Fatima, A et al. (2007) Reduced urocortin 1 immunoreactivity in the non-preganglionic Edinger-Westphal nucleus during late pregnancy in rats. Regul. Pept. 143 34-8 PubMed GONUTS page
  32. 32.0 32.1 32.2 32.3 32.4 32.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page