GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:12895659
| Citation |
Guzman, EA, Zhang, W, Lin, TR and Mulholland, MW (2003) Stimulation of rat pancreatic exocrine secretion by urocortin and corticotropin releasing factor. Peptides 24:727-34 |
|---|---|
| Abstract |
Neural and hormonal mechanisms control pancreatic secretion. The effects of the corticotropin releasing factor (CRF) related neuropeptide urocortin (UCN) on pancreatic exocrine secretion were examined. In anesthetized male rats, pancreatic secretion volume and total protein were assayed. UCN increased pancreatic secretory volume and protein secretion and potentiated cholecytokinin-stimulated protein secretion. Astressin, a non-specific CRF receptor antagonist, inhibited UCN-stimulated protein output while CRF(2) receptor antagonist, antisauvagine-30, was without effect. Atropine, but not subdiaphragmatic vagotomy, inhibited UCN-mediated secretion. In acinar cells, UCN did not stimulate release of amylase nor intracellular cAMP. UCN is a pancreatic exocrine secreatagogue with effects mediated through cholinergic intrapancreatic neurons. |
| Links | |
| Keywords |
Animals; Atropine/pharmacology; Corticotropin-Releasing Hormone/pharmacology; Cyclic AMP/metabolism; Humans; Male; Pancreas/metabolism; Pancreas/secretion; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone/metabolism; Time Factors; Urocortins; Vagotomy; Vasoactive Intestinal Peptide/pharmacology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0030157: pancreatic juice secretion |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
See Help:References for how to manage references in GONUTS.
