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PMID:17391780

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Citation

Fatima, A, Haroon, MF, Wolf, G, Engelmann, M and Spina, MG (2007) Reduced urocortin 1 immunoreactivity in the non-preganglionic Edinger-Westphal nucleus during late pregnancy in rats. Regul. Pept. 143:34-8

Abstract

Pregnancy is accompanied by an array of adaptive changes that play an important role in pre- and postnatal events. In rats, urocortin 1, a corticotropin-releasing factor-like peptide, is expressed mainly in the non-preganglionic Edinger-Westphal nucleus. We investigated the number of neurons immunoreactive for urocortin 1 at three different levels of the Edinger-Westphal nucleus in female rats by immunohistochemistry. The number of urocortin 1 immunoreactive cells was found to be decreased in pregnant rats compared to virgin rats. These results indicate that the hormonal status of the female rat affects urocortin 1 immunoreactive neurons in the non-preganglionic Edinger-Westphal nucleus and its signaling to target brain areas.

Links

PubMed Online version:10.1016/j.regpep.2007.02.010

Keywords

Animals; Corticotropin-Releasing Hormone/metabolism; Eating; Female; Immunohistochemistry; Male; Mesencephalon/cytology; Mesencephalon/metabolism; Neurons/metabolism; Pregnancy; Rats; Rats, Wistar; Time Factors; Urocortins

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:UCN1

involved_in

GO:0007565: female pregnancy

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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