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PMID:15694367

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Citation

Chanalaris, A, Lawrence, KM, Townsend, PA, Davidson, S, Jamshidi, Y, Jashmidi, Y, Stephanou, A, Knight, RD, Hsu, SY, Hsueh, AJ and Latchman, DS (2005) Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway. Biochem. Biophys. Res. Commun. 328:442-8

Abstract

The UCN homologues SCP and SRP bind specifically to the CRFR2 receptor, whereas UCN binds to both CRFR1 and CRFR2. We have previously demonstrated that all three peptides are cardioprotective, and both the Akt and MAPK p42/44 pathways are essential for this effect. Here we tested the hypertrophic effects of these peptides. We examined the effects of the peptides on cell area, protein synthesis, and induction of the natriuretic peptides ANP and BNP. All three peptides were able to increase all the markers of hypertrophy examined, with SCP being the most potent of the three, followed by UCN and SRP last. In addition, we provide a mechanism of action for the three peptides and show that Akt phosphorylation is important for their hypertrophic action, whereas MAPK p42/44 is not involved in this effect.

Links

PubMed Online version:10.1016/j.bbrc.2005.01.001

Keywords

Animals; Animals, Newborn; Cell Size/drug effects; Cells, Cultured; Corticotropin-Releasing Hormone/administration & dosage; Gene Expression Regulation/drug effects; Hypertrophy/chemically induced; Hypertrophy/metabolism; Hypertrophy/pathology; Myocytes, Cardiac/drug effects; Myocytes, Cardiac/metabolism; Myocytes, Cardiac/pathology; Protein-Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction/drug effects; Urocortins

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:UCN1

involved_in

GO:0030307: positive regulation of cell growth

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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