RAT:RNF34

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Rnf34 (ECO:0000312 with RGD:628636)
Protein Name(s)	E3 ubiquitin-protein ligase RNF34 (ECO:0000305) RING finger protein 34 (ECO:0000312 with RGD:628636) RING finger protein MOMO (ECO:0000303 with PMID:12859687^[1])
External Links
UniProt	Q6AYH3
EMBL	AY157968 BC079044
RefSeq	NP_001004075.1
UniGene	Rn.14904
ProteinModelPortal	Q6AYH3
STRING	10116.ENSRNOP00000001799
PRIDE	Q6AYH3
Ensembl	ENSRNOT00000001799
GeneID	282845
KEGG	rno:282845
UCSC	RGD:628636
CTD	80196
RGD	628636
eggNOG	NOG121302
GeneTree	ENSGT00390000012719
HOGENOM	HOG000068080
HOVERGEN	HBG055079
InParanoid	Q6AYH3
OMA	NPDFSTY
OrthoDB	EOG70GMFS
PhylomeDB	Q6AYH3
TreeFam	TF325195
Reactome	REACT_199254
UniPathway	UPA00143
NextBio	624935
PRO	PR:Q6AYH3
Proteomes	UP000002494
Genevestigator	Q6AYH3
GO	GO:0005737 GO:0005829 GO:0012505 GO:0016607 GO:0005634 GO:0005886 GO:0016874 GO:1901981 GO:0061630 GO:0004842 GO:0008270 GO:2001271 GO:1902042 GO:1901797 GO:0035872 GO:0043161 GO:0070936 GO:0016567 GO:0042787 GO:2000374
Gene3D	3.30.40.10
InterPro	IPR011011 IPR001841 IPR013083
SMART	SM00184
SUPFAM	SSF57903
PROSITE	PS50089

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0061630	ubiquitin protein ligase activity	PMID:25193658^[2]	ECO:0000314			F	Figure 1G	complete CACAO 10136
enables	GO:0061630	ubiquitin protein ligase activity	PMID:25193658^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969K3	P	Seeded From UniProt	complete
involved_in	GO:2000374	regulation of oxygen metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99KR6	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969K3	C	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969K3	F	Seeded From UniProt	complete
involved_in	GO:1901797	negative regulation of signal transduction by p53 class mediator	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969K3	P	Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969K3	P	Seeded From UniProt	complete
involved_in	GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969K3	P	Seeded From UniProt	complete
involved_in	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969K3	P	Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969K3	P	Seeded From UniProt	complete
enables	GO:1901981	phosphatidylinositol phosphate binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969K3	F	Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969K3	P	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969K3	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969K3	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969K3	C	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:12859687^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	P	Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	P	Seeded From UniProt	complete
enables	GO:1901981	phosphatidylinositol phosphate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	F	Seeded From UniProt	complete
involved_in	GO:1901797	negative regulation of signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	P	Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	P	Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	F	Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	P	Seeded From UniProt	complete
involved_in	GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	P	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	F	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	C	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	P	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	C	Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q969K3 ensembl:ENSP00000376258	F	Seeded From UniProt	complete
involved_in	GO:2000374	regulation of oxygen metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99KR6 ensembl:ENSMUSP00000031434	P	Seeded From UniProt	complete
involved_in	GO:0070417	cellular response to cold	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99KR6 ensembl:ENSMUSP00000031434	P	Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99KR6 ensembl:ENSMUSP00000031434	P	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99KR6 ensembl:ENSMUSP00000031434	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0147	C	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0186	C	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Araki, K et al. (2003) A palmitoylated RING finger ubiquitin ligase and its homologue in the brain membranes. J. Neurochem. 86 749-62 PubMed GONUTS page
↑ ^2.0 ^2.1 Jin, H et al. (2014) Ring finger protein 34 (RNF34) interacts with and promotes γ-aminobutyric acid type-A receptor degradation via ubiquitination of the γ2 subunit. J. Biol. Chem. 289 29420-36 PubMed GONUTS page

[PMID:12859687-1] 1.0 ^1.1 Araki, K et al. (2003) A palmitoylated RING finger ubiquitin ligase and its homologue in the brain membranes. J. Neurochem. 86 749-62 PubMed GONUTS page

[PMID:25193658-2] 2.0 ^2.1 Jin, H et al. (2014) Ring finger protein 34 (RNF34) interacts with and promotes γ-aminobutyric acid type-A receptor degradation via ubiquitination of the γ2 subunit. J. Biol. Chem. 289 29420-36 PubMed GONUTS page

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RAT:RNF34

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