RAT:NR1H3

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Nr1h3 (synonyms: Lxra)
Protein Name(s)	Oxysterols receptor LXR-alpha Liver X receptor alpha Nuclear receptor subfamily 1 group H member 3 RLD-1
External Links
UniProt	Q62685
EMBL	U11685
PIR	A56043
UniGene	Rn.11209
ProteinModelPortal	Q62685
SMR	Q62685
PhosphoSite	Q62685
PRIDE	Q62685
UCSC	RGD:61909
RGD	61909
eggNOG	NOG285805
HOGENOM	HOG000220845
HOVERGEN	HBG108655
InParanoid	Q62685
PhylomeDB	Q62685
PRO	PR:Q62685
Proteomes	UP000002494
Genevestigator	Q62685
GO	GO:0005737 GO:0005634 GO:0046982 GO:0046965 GO:0043565 GO:0003700 GO:0003707 GO:0008270 GO:0008286 GO:0006629 GO:2000188 GO:0006351
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR023257 IPR008946 IPR000536 IPR001723 IPR001628 IPR013088
Pfam	PF00104 PF00105
PRINTS	PR02034 PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0009306	protein secretion	PMID:19229075^[1]	ECO:0000315			P	Figure 2A and 2b: Inhibition of LXRα by using siRNA (in Fig 2A) or by using arachidonic acid (in Fig 2B) resulted in a decrease in secreted apoE protein, despite the presence of FGF-1, suggesting that LXRα plays a role in apoE secretion. NOTE: a more specific term could be used if it was available “apolipoprotein secretion”	complete
	GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	PMID:19229075^[1]	ECO:0000315			P	Figure 2A and 2b: Inhibition of LXRα by using siRNA (in Fig 2A) or by using arachidonic acid (in Fig 2B) resulted in a decrease in cellular apoE protein, despite the presence of FGF-1, suggesting that LXRα regulates apoE gene transcription. Figure 3: suggests that the upregulation of the apoE gene transcription in astrocytes is associated with the increase of LXRα, both being regulated by cellular sterol biosynthesis, as when the cells were treated with compactin, an inhibitor of HMG-CoA reductase (involved in the control of cholesterol biosynthesis), the FGF-1 induced increase of LXRα and apoE mRNA were decreased.	complete
	GO:0031490	chromatin DNA binding	PMID:19229075^[1]	ECO:0000314			F	Figure 5: Chip assay shows that LXRα binds to the apoE promoter	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13133	F	Seeded From UniProt	complete
involved_in	GO:2000325	regulation of nuclear receptor transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13133	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13133	P	Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13133	P	Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:21173252^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0Y9	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13133	P	Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0Y9	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:7935418^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0046965	retinoid X receptor binding	PMID:7935418^[3]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:736929	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:7935418^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:11781314^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:11781314^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16773041^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16773041^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637751 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:Q13133	C	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 MGI:MGI:1352464 PANTHER:PTN000637752 UniProtKB:Q13133	P	Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 MGI:MGI:1352463 PANTHER:PTN000637752 ZFIN:ZDB-GENE-050410-7	P	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637816	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:104740 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3371 RGD:3857 RGD:61906 RGD:628831 UniProtKB:O62807 UniProtKB:O75469 UniProtKB:P10276 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14994 UniProtKB:Q8JHU1 UniProtKB:Q96RI1 WB:WBGene00000908	P	Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 PANTHER:PTN000637752 UniProtKB:Q13133	P	Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN000637751	F	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637751 UniProtKB:O62807 UniProtKB:P37231	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN000637751	P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97856 PANTHER:PTN000637751 RGD:3371 RGD:3534 UniProtKB:P10276 UniProtKB:P10827 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869 ZFIN:ZDB-GENE-000210-31	F	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103076 PANTHER:PTN000637751	P	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000637752 RGD:61909	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0000568 MGI:MGI:101884 MGI:MGI:1346307 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:2444210 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3369 RGD:3370 RGD:3371 RGD:3534 RGD:3857 RGD:61909 RGD:621400 RGD:628831 UniProtKB:O62807 UniProtKB:P04625 UniProtKB:P10276 UniProtKB:P10826 UniProtKB:P10827 UniProtKB:P11473 UniProtKB:P13631 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:P68306 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14995 WB:WBGene00000908 WB:WBGene00003607 WB:WBGene00004786 ZFIN:ZDB-GENE-990415-263	C	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 PANTHER:PTN000637751 RGD:61906	F	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0015240 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 PANTHER:PTN000637751 UniProtKB:O75469 UniProtKB:P20393 UniProtKB:Q14994 UniProtKB:Q96RI1 WB:WBGene00004786	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:98742 PANTHER:PTN000637751 RGD:628827 UniProtKB:Q96RI1	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 PANTHER:PTN000637752 RGD:628831	P	Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P	Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003707	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F	Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR013088	P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F	Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	PMID:11781314^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Lu, R et al. (2009) FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J. Lipid Res. 50 1156-64 PubMed GONUTS page
↑ Korach-André, M et al. (2011) Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity. Proc. Natl. Acad. Sci. U.S.A. 108 403-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Apfel, R et al. (1994) A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol. Cell. Biol. 14 7025-35 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Tobin, KA et al. (2002) Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis. J. Biol. Chem. 277 10691-7 PubMed GONUTS page
↑ ^5.0 ^5.1 Helleboid-Chapman, A et al. (2006) Glucose regulates LXRalpha subcellular localization and function in rat pancreatic beta-cells. Cell Res. 16 661-70 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19229075-1] 1.0 ^1.1 ^1.2 Lu, R et al. (2009) FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J. Lipid Res. 50 1156-64 PubMed GONUTS page

[PMID:21173252-2] Korach-André, M et al. (2011) Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity. Proc. Natl. Acad. Sci. U.S.A. 108 403-8 PubMed GONUTS page

[PMID:7935418-3] 3.0 ^3.1 ^3.2 Apfel, R et al. (1994) A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol. Cell. Biol. 14 7025-35 PubMed GONUTS page

[PMID:11781314-4] 4.0 ^4.1 ^4.2 Tobin, KA et al. (2002) Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis. J. Biol. Chem. 277 10691-7 PubMed GONUTS page

[PMID:16773041-5] 5.0 ^5.1 Helleboid-Chapman, A et al. (2006) Glucose regulates LXRalpha subcellular localization and function in rat pancreatic beta-cells. Cell Res. 16 661-70 PubMed GONUTS page

[PMID:21873635-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:NR1H3

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